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Found 8 clinical trials
Phase II Trial of Radical Pleurectomy With or Without Intraoperative PDT for Malignant Pleural Mesothelioma

A randomized Phase II trial to test whether the addition of intraoperative Photofrin-mediated photodynamic therapy to radical pleurectomy and post-operative chemo.improves OS in the treatment of

  • 22 views
  • 02 Jun, 2021
  • 2 locations
Wedge Resection or Parietal Pleurectomy for the Treatment of Recurrent Pneumothorax (WOPP) (WOPP)

elaborated guidelines by the British Thoracic Society (BTS) postulating apical wedge resection of the lung and total parietal pleurectomy (WRPP), the majority of German hospitals gathered experience

atelectasis
thoracic surgery
wedge resection
pulmonary disease
pleurectomy
  • 24 views
  • 03 May, 2022
  • 21 locations
Pleurectomy/Decortication (Neo) Adjuvant Chemotherapy and Intensity Modulated Radiation Therapy to the Pleura in Patients With Locally Advanced Malignant Pleural Mesothelioma

lung itself. The purpose of this study is to test the safety and implementation of standard pleurectomy/decortication (removal of the surface lining of the lung) and standard chemotherapy followed by

renal function
cancer
pleurectomy
pemetrexed
immunomodulators
  • 15 views
  • 23 Jan, 2022
  • 12 locations
Nivolumab With Chemotherapy in Pleural Mesothelioma After Surgery

Patients with malignant pleural mesothelioma stage I-III who have undergone cytoreductive surgery with curative intend consisting of extended pleurectomy / decortication (eP/D) with or without

nivolumab
carboplatin
pleurectomy
pemetrexed
experimental drug
  • 1 views
  • 29 Apr, 2022
  • 8 locations
Mesothelioma and Radical Surgery 2

help treat mesothelioma and sometimes lung-sparing surgery (pleurectomy decortication) is undertaken. However, it is not known if this surgery, in addition to chemotherapy, can increase survival and

cancer
pleurectomy
asbestos exposure
chemotherapy regimen
  • 151 views
  • 23 Jan, 2021
  • 24 locations
dENdritic Cell Therapy Combined With SURgEry in Mesothelioma (ENSURE)

cell therapy (DCT), patients will undergo extrapleural pleurectomy/decortication (eP/D) surgery and receive three bi-weekly injections with DCT (starting 4 weeks after surgery). In total, five DC

  • 0 views
  • 08 Apr, 2022
  • 1 location
Testing the Addition of Targeted Radiation Therapy to Surgery and the Usual Chemotherapy Treatment (Pemetrexed and Cisplatin [or Carboplatin]) for Stage I-IIIA Malignant Pleural Mesothelioma

This trial studies how well the addition of targeted radiation therapy to surgery and the usual chemotherapy treatment works for the treatment of stage I-IIIA malignant pleural mesothelioma. Targeted radiation therapy such as intensity-modulated radiation therapy or pencil beam scanning uses high energy rays to kill tumor cells and shrink …

  • 0 views
  • 16 Nov, 2021
  • 9 locations
Autologous Dendritic Cell Vaccination in Mesothelioma

In this multicenter phase I/II trial, dendritic cells (DCs) loaded with the mesothelioma-associated tumor antigen WT1 will be used in conjunction with conventional chemotherapy for the frontline treatment of malignant pleural mesothelioma (MPM). The general objective is to provide the first-in-human experimental demonstration that the combination of platinum/pemetrexed-based chemotherapy with …

pemetrexed
thoracoscopy
  • 32 views
  • 31 Jan, 2021
  • 3 locations