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Found 51 clinical trials
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BEAT-meso: Bevacizumab and Atezolizumab in Malignant Pleural Mesothelioma

The aim of this clinical trial is to assess the effect of treatment with a monoclonal antibody called atezolizumab in patients diagnosed with a type of lung cancer called malignant pleural

  • 107 views
  • 14 May, 2021
  • 54 locations
None
Phase II Trial of Radical Pleurectomy With or Without Intraoperative PDT for Malignant Pleural Mesothelioma

A randomized Phase II trial to test whether the addition of intraoperative Photofrin-mediated photodynamic therapy to radical pleurectomy and post-operative chemo.improves OS in the treatment of patients with epithelioid MPM. Subjects assigned to the PDT arm will be given the photosensitizer prior to surgery . All subjects will receive maximal …

  • 22 views
  • 02 Jun, 2021
  • 2 locations
None
Pembrolizumab and Hypofractionated Stereotactic Radiotherapy in Patients With Malignant Pleural Mesothelioma

This is a multi-centre non-randomised open-label phase 1 trial of pembrolizumab given in combination with SBRT to part of a pleural-based lesion in patients with unresectable MPM. This study will recruit up to 18 patients whose MPM has progressed beyond first-line of palliative chemotherapy, with a platinum-based doublet, and now …

  • 0 views
  • 18 Apr, 2021
  • 4 locations
None
Ph 2/3 Study in Subjects With MPM to Assess ADI-PEG 20 With Pemetrexed and Cisplatin

This is a study of ADI-PEG 20 (pegylated arginine deiminase), an arginine degrading enzyme versus placebo in patients with malignant pleural mesothelioma. Malignant pleural mesothelioma have

chemotherapy regimen
pemetrexed
renal function
pleural mesothelioma
measurable disease
  • 0 views
  • 16 Mar, 2021
  • 45 locations
None
A Study of SAR444245 Combined With Other Anticancer Therapies for the Treatment of Participants With Lung Cancer or Mesothelioma

Primary Objective: To determine the antitumor activity of SAR444245 in combination with other anticancer therapies. Secondary Objectives: To confirm the dose and to assess the safety profile of SAR444245 when combined with other anticancer therapies. To assess other indicators of antitumor activity. To assess the pharmacokinetic (PK) profile of SAR444245 …

cancer chemotherapy
paclitaxel
pemetrexed
measurable disease
systemic therapy
  • 0 views
  • 03 Dec, 2021
  • 21 locations
None
Nivolumab and Ipilimumab +/- UV1 Vaccination as Second Line Treatment in Patients With Malignant Mesothelioma

The objective of the study is to induce a meaningful progression-free survival benefit in patients with Malign Pleural Mesothelioma (MPM) after progression on first line standard platinum

malignant mesothelioma
absolute neutrophil count
pleural mesothelioma
pemetrexed
platelet count
  • 62 views
  • 02 Nov, 2021
  • 7 locations
None
A Study of SGN-CD228A in Advanced Solid Tumors

This trial will study SGN-CD228A to find out whether it is an effective treatment for different kinds of cancer. It will also look at what side effects (unwanted effects) may occur. The study will have two parts. Part 1 of the study will find out how much SGN-CD228A should be …

cancer
targeted therapy
breast cancer
malignant melanoma of skin
lung cancer
  • 15 views
  • 19 Jan, 2022
  • 17 locations
None
Neoadjuvant Immune Checkpoint Blockade in Resectable Malignant Pleural Mesothelioma

The proposed study will evaluate the safety and feasibility of neoadjuvant nivolumab +/- ipilimumab in resectable MPM. In addition, maintenance nivolumab will be administered for 1 year following completion of standard bi-/tri-modality therapy.

pleural mesothelioma
resectable malignant pleural mesothelioma
platelet count
primary tumor
neutrophil count
  • 0 views
  • 15 Jul, 2021
  • 2 locations
None
Poly-ICLC (Hiltonol ) Vaccine In Malignant Pleural Mesothelioma

This study will examine the safety and potential effectiveness of poly-ICLC directly injected into malignant pleural mesothelioma at the time of biopsy up to 21 days prior to the cancer being

anticoagulation therapy
cancer
neutrophil count
  • 0 views
  • 25 Jan, 2021
  • 1 location
None
Prospectively Collected Pleural Biopsies for Validation of Malignant Pleural Mesothelioma Prognostic Biomarkers

This research study is evaluating a new method for determining stage and prognosis of individuals with malignant pleural mesothelioma.

thoracoscopy
pleural mesothelioma
pleural biopsy
  • 4 views
  • 29 Mar, 2021