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Found 172 clinical trials
A Study of IMP4297 as Maintenance Treatment Following First-line Chemotherapy in Patients With Advanced Ovarian Cancer

IMP4297 is a PARP inhibitor. This is a 2:1 randomized, double-blind, placebo-controlled study conducted in patients with advanced (FIGO Stage III or IV) ovarian cancer to evaluate Efficacy and Safety of IMP4297 for Maintenance Treatment

carboplatin
cancer chemotherapy
parp inhibitor
fallopian tube
peritoneal cancer
  • 12 views
  • 23 Jan, 2021
  • 2 locations
Sirolimus and Auranofin in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer or Small Cell Lung Cancer

This phase I/II trial studies the side effects and best dose of auranofin when given together with sirolimus and to see how well it works in treating patients with lung cancer that has spread or other places in the body and cannot be cured or controlled by treatment or has …

neutrophil count
conjugated bilirubin
biomarker analysis
recurrent non-small cell lung cancer
alopecia
  • 16 views
  • 11 Apr, 2021
  • 2 locations
Nivolumab With or Without Ipilimumab or Chemotherapy in Treating Patients With Previously Untreated Stage I-IIIA Non-small Cell Lung Cancer

This phase II trial studies how well nivolumab works when given alone and in combination with ipilimumab or chemotherapy in treating patients with previously untreated stage I-IIIA non-small cell lung cancer. Monoclonal antibodies, such as nivolumab and ipilimumab, may interfere with the ability of tumor cells to grow and spread. …

carboplatin
lung carcinoma
neutrophil count
monoclonal antibodies
carcinoma
  • 18 views
  • 02 Feb, 2021
  • 2 locations
Tislelizumab in Combination With Anlotinib With ES-SCLC as Maintenance Therapy After First Line Chemotherapy

To show that maintenance therapy with Tislelizumab plus Anlotinib will prolong Progression Free Survival in subjects with extensive stage disease small cell lung cancer who have completed first line chemotherapy.

  • 0 views
  • 26 Jan, 2021
  • 1 location
d-Limonene +Radiation +PlatinumBasedChemo for Xerostomia Prevention in LocallyAdvanced HNSCC

This study explores the safety of d-limonene, a commercially-available dietary supplement (food) as a potential therapeutic for the severe dry mouth (xerostomia) experienced by patients with head and neck cancer as a side effect of their anti-cancer treatment.

  • 0 views
  • 28 Feb, 2021
  • 1 location
Afatinib in Advanced Refractory Urothelial Cancer

This phase II trial studies how well afatinib dimaleate works in treating patients with urothelial cancer that cannot be removed surgically and has grown after treatment with standard first-line chemotherapy. Afatinib dimaleate may turn off the function of the epidermal growth factor (EGF) and human epidermal growth factor receptor 2 …

spiral computed tomography
carcinoma
absolute neutrophil count
chemotherapy regimen
ct scan
  • 29 views
  • 26 Jan, 2021
  • 4 locations
eRAPID: Online Symptom Reporting in Lung Cancer

Lung cancer is a leading cause of cancer-related ill-health and death in the United Kingdom (UK), but with advances in systemic anti-cancer therapies the prognosis for people in later stages is improving. There is growing evidence that electronic systems which enable patients to monitor and report symptoms can help improve …

  • 0 views
  • 26 Jan, 2021
  • 1 location
Neoadjuvant of Sintilimab Combined With Chemotherapy for Resectable NSCLC neoSCORE

This is a Phase 2, prospective, randomized, open-Label, single-center international study that assesses the efficacy and safety of neoadjuvant therapy with different cycles of sintilimab combined with chemotherapy for resectable NSCLC. This trial will also explore the biomarkers of neoadjuvant immunochemotherapy.

platelet count
carboplatin
paclitaxel
lung carcinoma
cancer chemotherapy
  • 0 views
  • 27 Mar, 2021
  • 1 location
Toripalimab Combined With Bevacizumab Nab-paclitaxel and Carboplatin for Untreated Metastatic Pulmonary Sarcomatoid Carcinoma

This study aimed to evaluate the efficacy and safety of first-line Toripalimab combined with bevacizumab, nab-paclitaxel and carboplatin in the treatment of patients with advanced pulmonary sarcomatoid carcinoma.

  • 0 views
  • 11 Apr, 2021
  • 1 location
Neoadjuvant Erlotinib for Operable Stage II or IIIA NSCLC With EGFR Mutations

This study examines preoperative Erlotinib in patients with operable stage II and IIIA Non-small-cell lung cancer (NSCLC) harboring EGFR mutations.

measurable disease
erlotinib
EGFR
  • 2 views
  • 26 Jan, 2021
  • 1 location