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Found 108 clinical trials
Acute Normovolemic Hemodilution in Complex Cardiac Surgery (ANH)

Postoperative bleeding in cardiac surgery is a frequent complication, and cardiac surgery utilizes 15-20% of the national blood supply. Packed red blood cells (pRBCs) are associated with worse short and long term outcomes. For each unit transfused, there is an additive risk of mortality (death) and cardiac adverse events. Despite …

bypass graft
postoperative bleeding
  • 14 Mar, 2022
  • 1 location
Effect of MitoQ on Platelet Function and Reactive Oxygen Species Generation in Patients With Sickle Cell Anemia (MitoQ)

MitoQ is commercially available as a dietary supplement and it has been tested as a potential drug in other diseases, but it has never been tested in patients with sickle cell disease. The goal of this research is to study if MitoQ, a molecule that works as an antioxidant by …

Accepts healthy volunteers
  • 25 Mar, 2022
  • 5 locations
STrategies for Anticoagulation in Patients With thRombocytopenia and Cancer-associated Thrombosis

Patients with cancer are prone to have blood clots, which are usually treated with blood thinners. The main complication of blood thinners is bleeding. This is especially a concern when the number of platelets in the blood is lower than 50,000 per microliter. The role of platelets is to stop …

  • 16 Oct, 2022
  • 1 location
Application of Stored Autologous Blood Transfusion Therapy Containing Hematopoietic Stem Cells for Bone Marrow Protection in Cervical Cancer Patients Treated With Chemoradiotherapy

The aim of this project is to promote the reconstruction of haematopoietic function after chemoradiotherapy for cervical cancer with the innovative use of autologous haematopoietic containing stem cell blood transfusion support.To explore the effect of stored hemopoietic stem cell support therapy on bone marrow protection after concurrent chemoradiotherapy, in order …

adenosquamous carcinoma
  • 17 Oct, 2022
  • 1 location
High-dose Chemotherapy+G-CSF in Peripheral Blood Stem Cell Mobilization in Patients With Multiple Myeloma

This study was a multi-center, randomized, prospective study. The purpose is to clarify that high-dose VP-16+G-CSF has better mobilization efficiency and less toxic and side effects compared with high-dose CTX+G-CSF, and minimize mobilization failure, so as to provide convenient and high-quality mobilization programs for clinical practice and enable more patients …

Accepts healthy volunteers
white blood cells
granulocyte colony stimulating factor
  • 07 Oct, 2022
  • 1 location
Post IVIG Medication in Children With Immune Thrombocytopenia

This study is a single hospital system, single-arm year-long pilot to evaluate the feasibility of enrolling children with ITP who are receiving IVIG for treatment of disease to a scheduled post-infusion medication for 72 hours following IVIG infusion. This year-long feasibility pilot will test the (1) feasibility of enrollment and …

treatment regimen
blood tests
  • 21 Apr, 2022
  • 1 location
Comparation Between Needles for EUS-guided Sampling of Solid Pancreatic Lesions

This is a randomized study in order to compare the diagnostic yield (primary outcome) of EUS-guided sampling of pancreatic solid lesions obtained with the 25-gauge Franseen and the 25-gauge standard needle in patients undergoing EUS-guided sampling of pancreatic solid masses without ROSE. Secondary outcomes are the number of extra passes …

  • 12 May, 2021
  • 1 location
Dose Escalation Study of Lithium With Oxaliplatin and Capecitabine in Advanced Oesophago-Gastric or Colorectal Cancer (Lithium)

This study is a phase Ib, open label, multi-centre trial designed to estimate the Maximum Tolerated Dose (MTD) of lithium when combined with a standard chemotherapy regimen of oxaliplatin and capecitabine in patients with advanced, unresectable, oesophago-gastric or colorectal cancer who have received no previous treatment for advanced disease (previous …

neutrophil count
human chorionic gonadotropin
kidney function test
  • 22 Mar, 2022
  • 2 locations
Ph1 Trial Test Safety of IL-21 NK Cells for Induction of R/R AML

This phase I trial studies the side effects of donor natural killer (NK) cell therapy in treating patients with acute myeloid leukemia that has come back (recurrent) or has not responded to treatment (refractory). Natural killer cells are a type of immune cell. Immunotherapy with genetically modified NK cells from …

carbon monoxide
ejection fraction
myeloid leukemia
  • 22 Mar, 2022
  • 1 location
Fecal Microbiota Transplantation for Steroid Resistant/Dependent Acute GI GVHD (FEMITGIGVHD)

The purpose of this study is to evaluate the efficacy and safety of fecal microbiome transplantation in patients with steroid resistant/dependent acute gastrointestinal graft-versus-host disease (GVHD). The patient will cease antibiotics treatment 1 day before FMT, and stop taking food 6 hours before FMT. Patients will be given Ondansetron intravenously …

cell transplantation
blood disorder
hematologic disorders
graft versus host disease
  • 04 Mar, 2022
  • 2 locations