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Found 32 clinical trials
Platelet Transfusion in Acute-on Chronic Liver Failure

2-3 grade and inhibition rate beyond 70% was improved and the 28-day mortality decreased after platelet transfusion. Whether platelet transfusion can prolong survival time needs to be determined in

  • 26 Jan, 2021
  • 8 locations
Hyperbaric Oxygen Therapy for Hemorrhagic Cystitis Post HSCT

, immunosuppressant reduction, and platelet transfusion. Patients with viral infection may be treated with antiviral agents, but their efficacy is limited. When the HC was considered to be associated with aGVHD, some

clot formation
cell transplantation
graft versus host disease
hemorrhagic cystitis
acute graft-versus-host disease
  • 18 Sep, 2021
  • 1 location
Assessing the Hemostatic Efficacy of Pathogen Reduced Platelets in Children Undergoing Cardiopulmonary Bypass Surgery: A Pilot Clinical Trial (PEDITREC)

This study is testing whether pathogen reduced platelets can control bleeding as well as non-pathogen reduced platelets (otherwise known as large volume delayed sampling).

  • 20 Aug, 2022
  • 1 location
Enhancement of the Haemostatic Effect of Platelets in the Presence of High Normal Concentrations of Von Willebrand Factor (Will-Plate)

Assessment of high-normal dosage of Wilate ® compared to placebo administered in combination with platelets to assess reduction of amount of blood loss, need of transfusion products and outcome (length of stay, mortality) in patients with bleeding in comparison.

coagulation factor
  • 23 Sep, 2022
  • 1 location
Platelet Transfusions in Hematopoietic Stem Cell Transplantation (The PATH III Trial) (PATH)

It is hypothesized that a strategy using prophylactic oral and intravenous Tranexamic Acid (TXA) with therapeutic platelet transfusions (if required) is safe and more effective than prophylactic

cell transplantation
hematologic malignancy
tranexamic acid
  • 09 Jul, 2022
  • 4 locations
The Cryopreserved vs. Liquid Platelets Trial (CLIP II)

This trial is a phase III multicentre blinded randomised controlled clinical non-inferiority trial of cryopreserved platelets vs. conventional liquid-stored platelets for the management of surgical bleeding. The aim of the study is to assess the efficacy, safety and cost effectiveness of cryopreserved platelets, compared to conventional liquid-stored platelets, for the …

  • 23 Jul, 2022
  • 6 locations
A Phase 3, Double-blind, Randomized Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK Inhibitor Therapy and Who Require Red Blood Cell Transfusions (INDEPENDENCE)

The purpose of this Phase 3 study is to evaluate the efficacy and safety of Luspatercept compared with placebo in subjects with myeloproliferative neoplasm (MPN)-associated Myelofibrosis (MF) and anemia on concomitant Janus kinase 2 (JAK2) inhibitor therapy and who require red blood cell count (RBC) transfusions. The study is divided …

bilateral oophorectomy
  • 22 Sep, 2022
  • 136 locations
Short or Long Infusion Duration for Platelets: The SOLID Platelet Study

can cause severe bleeding. Some people are not helped by platelet transfusions at the standard transfusion rate. This is called platelet transfusion refractoriness (PTR). Researchers want to learn

blood transfusion
pulmonary hemorrhage
hematologic malignancy
platelet transfusion
  • 19 Sep, 2022
  • 1 location
Sequential Infusion of CD19 and BCMA CAR-T Cells to Improve PTR in Patients With AL

Alloimmune-mediated platelet transfusion refractoriness(PTR) was usually caused by repeated blood transfusions and pregnancy and accounts for about 20-25% of PTR patients. Patients with acute

  • 06 Nov, 2021
  • 1 location
A Randomized, Double-blind, Placebo-controlled, Japan Local Phase II Clinical Study Comparing Eltrombopag Monotherapy Versus Placebo in Adult Lower-risk Myelodysplastic Syndromes (MDS) Patients With Platelet Transfusion Dependence

This study is designed to evaluate the efficacy and safety of eltrombopag monotherapy in Japanese adult patients with platelet transfusion-dependent lower-risk Myelodysplastic syndromes (LR-MDS

  • 23 Sep, 2022
  • 19 locations