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Found 53 clinical trials
Study on Tirofiban With Aspirin in the Treatment of Acute Penetrating Artery Territory Infarction (STRATEGY)

Perforating artery territorial infarction (PAI) refers to a single ischaemic lesion <20 mm in a single perforating arterial territory and branch atheromatous disease (BAD) is a important etiological factor. BAD related infarction accounts for 10%-15% ischemic cerebral infarction and is closely related to early neurological deterioration (END). Among patients with …

  • 14 May, 2022
  • 20 locations
Consumption of Oral Artificial Sweeteners on Platelet Aggregation and Polyol Excretion (COSETTE)

The principal goal for the study is to examine whether ingestion of a beverage containing artificial sweeteners alters in vitro platelet aggregation. Because of the increasing number of

Accepts healthy volunteers
  • 11 May, 2022
  • 1 location
The Effect of Daily Mango Intake on Cardiovascular Health

hypothesize that the daily intake of 330 grams of mango (2 cups) will significantly increase PAT while reducing platelet aggregation after 2 hours and two weeks of daily intake.

Accepts healthy volunteers
  • 25 Feb, 2022
  • 1 location
Ilomedin in Septic Shock With Persistent Microperfusion Defects (I-MICRO) (I-MICRO)

disorders. Ilomedin is a prostaglandin analog with a potent vasodilatory effect together with anti-thrombotic properties (inhibition of platelet aggregation) preferentially at the microcirculatory level. An

  • 26 Feb, 2022
  • 1 location
Enhancement of the Haemostatic Effect of Platelets in the Presence of High Normal Concentrations of Von Willebrand Factor (Will-Plate)

Assessment of high-normal dosage of Wilate ® compared to placebo administered in combination with platelets to assess reduction of amount of blood loss, need of transfusion products and outcome (length of stay, mortality) in patients with bleeding in comparison.

coagulation factor
  • 06 May, 2022
  • 1 location
A Study Evaluating the Safety and Efficacy of Tirofiban in Combination With Alteplase in Acute Ischemic Stroke (RESET)

The study is a prospective, multicenter, randomized, double-blind, placebo-controlled study evaluating the safety and efficacy of tirofiban in combination with intravenous thrombolytic therapy with alteplase in acute ischemic stroke

  • 25 Mar, 2022
  • 1 location
Platelet Function in Patients With Ischemic Stroke Treated With Anti-thrombotic or Thrombolytic

Acute stroke afflicts nearly 700,000 patients in the US and is the number 3 cause of death. Only 2-9% of this large number is treated with t-PA if they arrive within 4.5 hours. An equally small percentage of patients with large vessel occlusion undergo thrombectomy. The thrombectomy patients may or …

  • 19 Jun, 2022
  • 1 location
Impact of Von Willebrand Factor-platelet Aggregates in Patients With Type 2B Disease

The working hypothesis is that patients with Von Willebrand Disease-type 2B may have neurological symptoms due to the chronic formation of platelets/Von Willebrand Factor aggregates. Interestingly, several patients present nonspecific neurological symptoms (nystagmus, headaches, memory disorder, ) which may be associated with cerebral microangiopathy and chronic microvessel inflammation secondary to …

  • 25 Aug, 2021
  • 1 location
Perioperative Antiplatelet Therapy in Patients With Drug-eluting Stent Undergoing Noncardiac Surgery (ASSURE-DES)

The purpose of this study is to evaluate the safety and effectiveness of perioperative antiplatelet therapy in patients with drug-eluting stent undergoing non-cardiac surgery.

  • 24 Feb, 2022
  • 23 locations
THrombo-Embolic Event in Onco-hematology (THEO)

patients on vitamin K antagonists. (AVK), anti-platelet aggregation (AGP) and / or direct oral anticoagulant (AOD). In this study, the investigator means by hypocoagulability any situation modifying

platelet aggregation
sample analysis
deep vein thrombosis
  • 25 Apr, 2022
  • 1 location