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Found 32 clinical trials
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Short-term Survival of Subjects With Acute-on-chronic Liver Failure After Plasma Exchange With Human Serum Albumin 5%

This is a Phase 3, multicenter, randomized, controlled, parallel-group, open-label study to evaluate the effects of plasma exchange using human serum albumin 5% (PE-A 5%) in acute-on-chronic

plasma exchange
  • 35 views
  • 30 Sep, 2021
  • 45 locations
None
Randomised Study of Plasma Exchange in Severe COVID-19

cardiac function throughout the period of therapy. As plasma exchange is an intensive treatment modality, blocks of 5 daily PEX will be undertaken. Further blocks of PEX treatment can be initiated as

  • 0 views
  • 26 Jan, 2021
  • 1 location
None
Effectiveness of Plasma Exchange in Treating With Severe Acute AQP4-Ab Positive Optic Neuritis

, are chosen by the physician. Patients will then be randomized to receive high dose of intravenous corticosteroids combined with plasma exchange (PE), or merely high dose of intravenous corticosteroids

aquaporin-4
immunoglobulin g
corticosteroids
  • 4 views
  • 22 Aug, 2021
  • 1 location
None
Effects of Single Plasma Exchange and Double Filtration Plasmapheresis (DFPP) on Peripheral Lymphocyte Phenotypes in Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy

from plasma but it is uncertain whether it has an immune-modulating effect. Also, the refining mechanisms of the two main plasmapheresis techniques - single plasma exchange and double filtration

weakness
plasma exchange
polyneuropathy
igiv
  • 0 views
  • 19 Jul, 2021
  • 1 location
None
Combination Therapy With Carfilzomib for the Antibody-Mediated Rejection Diagnosis in Lung Transplantation

The clinical trial is a Phase II open label, single-arm pilot study to evaluate the safety and efficacy of combination therapy with carfilzomib, plasma exchange and intravenous immunoglobulins

  • 2 views
  • 24 Jan, 2021
  • 1 location
None
Trial of Rituximab Given Pre-Transplant to Sensitised Live Donor Kidney Recipients

About one third of prospective kidney transplant recipients have antibodies in their blood directed against the tissues of their only available kidney donor. Recently, "desensitisation" treatments when administered pre-transplant have allowed successful transplantation of these patients despite high rates of acute antibody mediated rejection (AAMR). The investigators propose to test …

  • 28 views
  • 07 Nov, 2020
  • 3 locations
None
A Study of Imlifidase in Patients With Guillain-Barr Syndrome

The study participants are patients which have been diagnosed with Guillain-Barr Syndrome (GBS) and are planned to receive treatment with intravenous immunoglobulin (IVIg). IVIg is a standard of care treatment for GBS patients. The patients in this study will be treated with the study medicine imlifidase on day 1, and …

  • 18 views
  • 18 Sep, 2021
  • 15 locations
None
An Efficacy and Safety Study of Imlifidase in Treatment of Antibody-Mediated Rejection in Kidney Transplant Patients

The purpose of this study is to investigate how efficiently the study medication imlifidase reduces the amount of donor specific antibodies (DSA) in comparison with plasma exchange (PE) therapy

plasma exchange
kidney biopsy
antibody-mediated rejection
kidney transplant
  • 3 views
  • 01 Oct, 2021
  • 17 locations
None
Rapid Normalization of Vitamin D Deficiency in PICU

Vitamin D plays an important role in calcium balance, heart and lung health, inflammation, infection prevention, and muscle strength. Due to these roles, it has been suggested that critically ill patients with low vitamin D levels might have higher rates of death and worse long-term health. We believe that identifying …

vitamins
calcium
cholecalciferol
malnutrition
  • 22 views
  • 10 Oct, 2021
  • 10 locations
None
RescuE pLAsma eXchange in Severe COVID-19

evidence for the development of prothrombotic autoantibodies as an epiphenomenon of "Severe Acute Respiratory Syndrome Coronavirus 2" (SARS-CoV-2) infection. Therapeutic plasma exchange ("TPE") is being

  • 0 views
  • 29 Apr, 2021
  • 4 locations