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Found 22 clinical trials
Postpartum Low-Dose Aspirin After Preeclampsia for Optimization of Cardiovascular Risk (PAPVASC) (PAPVASC)

. Treatment groups will receive 81 mg daily oral aspirin, while control groups will receive an equivalent placebo pill. Vascular functional assessment at study outset will take place, combining laser speckle

aspirin
  • 7 views
  • 01 May, 2022
  • 1 location
Automated Abdominal Binder for Orthostatic Hypotension

The automated inflatable abdominal binder is an investigational device for the treatment of orthostatic hypotension (low blood pressure on standing) in patients with autonomic failure. The purpose of this study is to determine safety and effectiveness of the automated abdominal binder in improving orthostatic tolerance in these patients.

midodrine
atrophy
systolic blood pressure
orthostatic hypotension
pure autonomic failure
  • 22 views
  • 04 Oct, 2022
  • 1 location
Effects of Metformin on Airway Ion Channel Dysfunction in Cystic Fibrosis-related Diabetes

The purpose of this study is to assess the efficacy of metformin to improve airway ion channel function in those with CF-related diabetes (CFRD)

tezacaftor
insulin
diabetes
fibrosis
ivacaftor
  • 0 views
  • 12 Mar, 2022
  • 1 location
Novel, Non-Hormonal Therapy for the Treatment of Chronic Pain Due to Endometriosis in Adolescent and Adult Women

Endometriosis is dependent on angiogenesis (the sprouting of new blood vessels) for its growth and maintenance, but the side effects of currently approved angiogenesis inhibitors make these agents inappropriate for use in reproductive-age patients. This obstacle will be overcome by performing a randomized, double blind clinical trial aimed at repurposing …

  • 18 views
  • 11 Oct, 2022
  • 1 location
Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients

The purpose of this study is to learn more about the effects of abdominal compression and the medication midodrine, two interventions used for the treatment of orthostatic hypotension (low blood pressure on standing), on hemodynamic markers of cardiovascular risk. The study will be conducted at the Vanderbilt University Medical Center …

midodrine
pure autonomic failure
systolic blood pressure
orthostatic hypotension
  • 0 views
  • 19 Jun, 2022
  • 1 location
Efficacy of Preoperative Administration of Gabapentin in 3rd Molar Dental Extraction.

This study is a double-blind, randomized, prospective, placebo-controlled single-center clinical research study in which 600 mg of gabapentin or placebo will be administered 2 hours preoperatively to 49 patients each undergoing wisdom teeth extraction. We will measure intraoperative opioid use, severity of pain, the number of analgesics taken, and side …

Accepts healthy volunteers
  • 0 views
  • 07 Jul, 2022
  • 1 location
Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure

The purpose of this study is to learn more about the effects of midodrine and droxidopa, two medications used for the treatment of orthostatic hypotension (low blood pressure on standing), on the veins of the abdomen of patients with autonomic failure. The study will be conducted at Vanderbilt University Medical …

droxidopa
midodrine
atrophy
systolic blood pressure
orthostatic hypotension
  • 277 views
  • 16 Jun, 2022
  • 1 location
Alcoholic Liver Disease and the Gut Microbiome

Background: Significant sex differences exist in regard to alcohol use disorder (AUD) and alcoholic liver disease (ALD). To date, no studies have examined the brain-gut-microbiome (BGM) axis (which is the relationship between the gut, brain, and the bacteria within the gut) and sex-differences in AUD and ALD. Aims: 1) Demonstrate …

Accepts healthy volunteers
  • 0 views
  • 30 May, 2022
  • 1 location
Can Probiotics be Used in the Prevention of Recurrent UTI in Paediatric Neurogenic Bladder

Although clean intermittent catheterization (CIC) remains the mainstay to ensure complete low-pressure bladder emptying in neurogenic bladder (NB) patients, this forms a vehicle for bacterial entry and colonization of the urinary tract, which can lead to recurrent urinary tract infection (RUTI) and renal damage. Up to 25% of NB patients …

neurogenic bladder
intermittent catheterization
antibiotic prophylaxis
antimicrobials
antibiotics
  • 0 views
  • 15 Sep, 2021
  • 1 location
The Pill Project - Oral Contraceptive and Serotonergic Brain Signaling

Large register based work has shown that starting on oral contraceptives (OCs) is associated with an increased risk of developing depressive episodes. It is not known why this is, but changes in the serotonergic brain system might play a role. Intriguingly, in cross-sectional work, the investigators have demonstrated a lower …

Accepts healthy volunteers
  • 0 views
  • 11 Mar, 2022
  • 1 location