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Found 10 clinical trials
Featured trial
Study to evaluate HZN-825 in patients with Idiopathic Pulmonary Fibrosis (IPF)

The goal is to determine the efficacy, safety and tolerability for 360 patients with Idiopathic Pulmonary Fibrosis (IPF) assigned to either one of 2 dose regimens of HZN-825 (administered once daily (QD) or twice daily (BID)) or a placebo regimen for 52 weeks. Participants who complete the duration of this …

diffusion capacity of the lung for carbon monoxide
emphysema
pneumonia
  • 10 views
  • 22 Sep, 2022
  • 28 locations
Management of Progressive Disease in Idiopathic Pulmonary Fibrosis (PROGRESSION)

-modifying therapies, pirfenidone and nintedanib, have been approved worldwide. Both drugs reduce the disease progression as measured by progressive decline in forced vital capacity (FVC), with a reduction

  • 23 views
  • 24 Mar, 2022
  • 9 locations
Zephyrus II: Efficacy and Safety Study of Pamrevlumab in Participants With Idiopathic Pulmonary Fibrosis (IPF)

This is a Phase 3 trial to evaluate the efficacy and safety of 30 mg/kg intravenous (IV) infusions of pamrevlumab administered every 3 weeks as compared to placebo in participants with Idiopathic Pulmonary Fibrosis (IPF). There is a 48-week randomized treatment phase followed by an optional, open-label extension phase.

pamrevlumab
idiopathic pulmonary fibrosis
carbon monoxide
nintedanib
diffusion capacity of the lung for carbon monoxide
  • 67 views
  • 14 Jul, 2022
  • 103 locations
Pirfenidone to Prevent Fibrosis in Ards. (PIONEER)

disease affects ARDS patients even years after acute phase resolution. Pirfenidone is an oral anti-fibrotic drug, approved and largely used for treatment of idiopathic pulmonary fibrosis (IPF). The

fibrosis
pulmonary fibrosis
acute lung injury
acute respiratory distress
  • 0 views
  • 10 Jul, 2022
  • 2 locations
Immunosuppressant Combined With Pirfenidone in CTD-ILD

A prospective cohort study was used to observe the efficacy and safety of different immunosuppressive agents with/wo pirfenidone on CTD-ILD patients in Qilu Hospital of Shandong University for

progressive systemic sclerosis
dyspnea
immunosuppressive
pirfenidone
rheumatism
  • 2 views
  • 24 Jun, 2021
  • 1 location
Trial of Pirfenidone to Prevent Progression in Chronic Kidney Disease (TOP-CKD)

will use these measures to evaluate pirfenidone as a promising potential new treatment for patients with kidney disease.

nephropathy
renal failure
cardiovascular disease
heart failure
  • 9 views
  • 16 May, 2022
  • 2 locations
Pirfenidone for the Reduction of Metabolic, Inflammatory and Fibrogenic Activity in Complicated Silicosis

nintedanib and pirfenidone. The antifibrotic properties of pirfenidone have raised great expectations and many clinical trials are currently being carried out in other lung diseases that cause fibrosis

  • 0 views
  • 25 Mar, 2022
Prospective Treatment Efficacy in IPF Using Genotype for Nac Selection (PRECISIONS) Trial (PRECISIONS)

The purpose of this study is to compare the effect of n-acetylcysteine (NAC) plus standard care with matched placebo plus standard of care in patients diagnosed with idiopathic pulmonary fibrosis (IPF) who have the TOLLIP rs3750920 TT genotype. The study will compare the time to a composite endpoint of relative …

nintedanib
acetylcysteine
forced vital capacity
pirfenidone
  • 5 views
  • 04 Oct, 2022
  • 21 locations
Evaluation of Efficacy and Safety of Pamrevlumab in Patients With Idiopathic Pulmonary Fibrosis

This is a Phase 3 trial to evaluate the efficacy and safety of 30 mg/kg intravenous (IV) infusions of pamrevlumab administered every 3 weeks as compared to placebo in subjects with Idiopathic Pulmonary Fibrosis

pamrevlumab
idiopathic pulmonary fibrosis
carbon monoxide
nintedanib
diffusion capacity of the lung for carbon monoxide
  • 737 views
  • 04 Oct, 2022
  • 17 locations
Jin-shui Huan-xian Granule in the Treatment of IPF

This study is to evaluate the efficacy and safety of Jin-shui Huan-xian granule for idiopathic pulmonary fibrosis (IPF), establish the treatment scheme, and obtain the high quality clinical evidences.

idiopathic pulmonary fibrosis
  • 2 views
  • 04 Oct, 2022
  • 1 location