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Found 6 clinical trials
Enrichment Randomized Double-blind, Placebo-controlled Cross-over Trial With PHEnytoin Cream in Patients With Painful Chronic Idiopathic Axonal polyNEuropathy (EPHENE)

Objectives: The main objective is to evaluate the efficacy and safety of phenytoin cream in patients with neuropathic pain due to chronic idiopathic axonal polyneuropathy (CIAP). The second

  • 0 views
  • 28 Oct, 2022
  • 1 location
Oral SM-88 in Patients With Metastatic HR+/HER2- Breast Cancer (OASIS)

This is a phase II single arm, open-label study of SM-88 used with methoxsalen, phenytoin, and sirolimus (MPS) in metastatic HR+/HER2- breast cancer. It is designed to determine efficacy

mammogram
cish
measurable disease
her2/neu-negative breast cancer
chromogenic in situ hybridization
  • 0 views
  • 06 May, 2022
  • 5 locations
SM-88 as Maintenance Therapy for Advanced Ewing's Sarcoma Patients and as Salvage Therapy for Sarcoma Patients (HopES)

The primary objective is to evaluate the efficacy of SM-88, a combination metabolic cancer treatment, in two study cohorts: Clinically advanced Ewing's Sarcoma patients who have not progressed at the conclusion of systemic treatment Clinically advanced sarcoma patients in the salvage treatment setting Up to 24 efficacy evaluable patients (up …

metastasis
metastatic sarcoma
advanced sarcoma
measurable disease
systemic therapy
  • 2 views
  • 16 May, 2022
  • 1 location
DTG Plus 3TC for Prophylaxis of Mother-to-child Transmission of HIV Infection in Pregnant Women (PREGNANT)

The study aims to evaluate the safety and efficacy of a 2 drugs ART regimen (lamivudine plus dolutegravir) for prevention of mother to child transmission in pregnant women with HIV. 20 pregnant women will be enrolled in this proof of concept protocol. They will be prescribed DTG-3TC (fixed-dose combination), and …

mother-to-child transmission
dolutegravir
lamivudine
Accepts healthy volunteers
  • 0 views
  • 25 Mar, 2022
  • 1 location
Antiepileptic Drugs in Elderly Patients

The purpose is to study the population pharmacokinetics, effectiveness and safety of antiepileptic drug (phenytoin, carbamazepine, lamotrigine, levetiracetam, parempanel, etc) in elderly

levetiracetam
phenytoin
carbamazepine
perampanel
antiepileptics
  • 0 views
  • 04 Oct, 2022
  • 1 location
Direct Oral Anticoagulant Levels in Chinese Patients With Atrial Fibrillation - A Real- World Pharmacokinetic Study (DOAC-REAL)

Direct oral anticoagulants (DOACs) have emerged as safe and efficacious ischemic stroke prophylaxis for non-valvular atrial fibrillation (NVAF). All four DOACs - apixaban, dabigatran, edoxaban, and rivaroxaban - were shown to reduce the risk of major bleeding compared to warfarin. The predictable pharmacokinetic profiles of DOACs also favour their use …

  • 0 views
  • 24 Oct, 2022
  • 1 location