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Found 16 clinical trials
Triple Combination of Pevonedistat and Venetoclax Plus Azacitidine in Adults With Acute Myeloid Leukemia Who Are Unfit for Intensive Chemotherapy

The purpose of this study is to determine whether the combination of pevonedistat + venetoclax + azacitidine improves event-free survival (EFS) compared with venetoclax + azacitidine in patients

gilbert's syndrome
leukapheresis
ejection fraction
venetoclax
carbon monoxide
  • 2 views
  • 16 May, 2021
  • 59 locations
Pevonedistat Plus Azacitidine Versus Single-Agent Azacitidine as First-Line Treatment for Participants With Higher-Risk Myelodysplastic Syndromes (HR MDS) Chronic Myelomonocytic Leukemia (CMML) or Low-Blast Acute Myelogenous Leukemia (AML)

The purpose of this study is to determine whether the combination of pevonedistat and azacitidine improves event-free survival (EFS) when compared with single-agent azacitidine. (An event is

chronic myelomonocytic leukemia
blast cells
leukemia
pevonedistat
azacitidine
  • 341 views
  • 24 Jul, 2021
  • 320 locations
Azacitidine Venetoclax and Pevonedistat in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia

This phase I/II trial studies the best dose of venetoclax when given together with azacitidine and pevonedistat and to see how well it works in treating patients with newly diagnosed acute

venetoclax
chromosome abnormalities
polycythemia vera
chronic eosinophilic leukemia
thrombocythemia
  • 40 views
  • 18 Mar, 2021
  • 1 location
Pevonedistat and Belinostat in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome

This phase I trial studies side effects and best dose of pevonedistat and belinostat in treating patients with acute myeloid leukemia or myelodysplastic syndrome that has come back (relapsed) or

  • 0 views
  • 16 Jul, 2021
  • 4 locations
Pevonedistat Alone and in Combination With Chemotherapy in Patients With Mesothelioma

The purpose of this study is to test any good and bad effects of activity pevonedistat taken alone, and also to test the safety of pevonedistat in combination with standard chemotherapy

gilbert's syndrome
peritoneal mesothelioma
direct bilirubin
pemetrexed
pleural mesothelioma
  • 14 views
  • 26 Jan, 2021
  • 8 locations
Treatment of MDS/AML Patients With an Impending Hematological Relapse With AZA or ATA and Pevonedistat

MDS/AML with MRD and impending relapse after allogeneic stem cell transplantation and/or conventional chemotherapy

  • 0 views
  • 05 May, 2021
  • 14 locations
Pevonedistat and Ibrutinib in Treating Participants With Relapsed or Refractory CLL or Non-Hodgkin Lymphoma

This phase I trial studies the side effects and best dose of pevonedistat when given together with ibrutinib in participants with chronic lymphocytic leukemia or non-Hodgkin lymphoma that has

mantle cell lymphoma
venetoclax
richter's transformation
flow cytometry
lymphoid leukemia
  • 12 views
  • 17 Jul, 2021
  • 2 locations
Pevonedistat and Low Dose Cytarabine in Adult Patients With AML and MDS

The investigators hypothesize that the combination of Pevonedistat/Low-Dose Cytarabine (LDAC) therapy will be tolerable, that a recommended phase 2 dose of Pevonedistat in combination with LDAC

gilbert's syndrome
hydroxyurea
blast cells
cytarabine
bone marrow procedure
  • 21 views
  • 16 Jun, 2021
  • 1 location
Pevonedistat With VXLD Chemotherapy for Adolescent/Young Adults With Relapsed/Refractory ALL or Lymphoblastic NHL

The investigators postulate that Pevonedistat will be effective in patients with relapsed/refractory acute lymphoblastic leukemia (ALL) when combined with a standard backbone ALL chemotherapy

  • 14 views
  • 19 Feb, 2021
  • 2 locations
Pevonedistat in Combination With Ruxolitinib for Treatment of Patients With Myelofibrosis

Based on the investigators' preclinical data, the combination of pevonedistat and ruxolitinib may provide greater clinical responses in patients with myelofibrosis compared to ruxolitinib

polycythemia
neutrophil count
ruxolitinib
conjugated bilirubin
direct bilirubin
  • 60 views
  • 25 Jun, 2021
  • 1 location