Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
I am looking for
added new label for I am looking for
Advanced Filters
Found 199 clinical trials
Contribution of Inflammation and Neuronal Integrity Markers in Patients With First-episode Conversive Motor Disorder (HYCOIN)

Conversion disorders, also called "dissociative disorders" (ICD-10), or "functional neurological disorders" (DSM-5), are a common condition, with a prevalence of 1-10% in medical and surgical inpatients (Toone 1990), and 10-30% in neurology patients (Carson et al. 2000). They are characterized by the presence of symptoms or deficits affecting voluntary motor, …

  • 01 May, 2022
Synaptic Loss in Multiple System Atrophy

In this study the investigators would like to investigate the degree of damage of the synapses, an important part of the neurons vital for the communications between neurons, in Multiple System Atrophy (MSA).

  • 25 Jan, 2022
  • 1 location
Circulating Tumor DNA (ctDNA) in Locally Advanced Esophageal and Gastroesophageal (GE) Junction Adenocarcinoma (TRACT DNA)

This is an observational study to determine the feasibility of assessing tumor response utilizing ctDNA in patients of locally advanced esophageal and gastroesophageal junction (LA-EA/GEJ) cancer undergoing total neoadjuvant therapy (TNT) consisting of systemic chemotherapy (modified FOLFOX or FLOT/DFOX) followed by concurrent chemoradiation [50.4 Gray (Gy) over approximately six weeks …

  • 03 Jun, 2022
  • 1 location
Hypoxia-Specific Imaging to Predict Outcomes of Chimeric Antigen Receptor T-cell Therapy

This study evaluates whether tumors present in patients with cancer who are planned to get CAR T-cells have low amounts of oxygen (hypoxia). PET scans may be used to check the amounts of oxygen within areas of cancer with a special radioactive tracer called FAZA that specifically looks for areas …

  • 14 Jun, 2022
  • 1 location
Dynamic Whole Body Positron Emission Tomography/Computed Tomography Imaging

Quantitative parameters obtained with dynamic whole body imaging using positron emission tomography (PET) can provide additional and complementary information to standard PET. Dynamic imaging allows for better understanding of the behavior of the radio-pharmaceutical because it can be followed over time. Thought to be difficult to perform with currently available …

pet/ct scan
positron emission tomography
  • 24 Feb, 2022
  • 1 location
Detection of Brown Adipose Tissue by Magnetic Resonance Imaging (BAT_PET/MRI)

The primary goal of this study is to assess the accuracy of conventional fat fraction proton MRI for the detection of Brown Adipose Tissue (BAT) in healthy subjects using 18F-2-fluoro-2-deoxy-D-glucosefluorodeoxyglucose -PET as gold standard. In this pilot study, MRI and PET imaging of BAT of healthy adult volunteers will be …

Accepts healthy volunteers
  • 16 Jun, 2022
  • 1 location
Early Response Evaluation of Proton Therapy by PET-imaging in Squamous Cell Carcinoma Located in the Head and Neck (ERM-PT-HNSCC)

The goal of this project is to develop and characterise an imaging strategy for biology-guided individualisation of the proton therapy plan to improve patient outcome and quality-of-life. Positron-emission tomography (PET) studies reflecting glucose metabolism, hypoxia and physical changes of proton-irradiated tumour tissues will be performed. Patients with head and neck …

  • 19 Apr, 2022
Tau PET Imaging in the NACC Study Cohort (TPI)

The purpose of this study is to measure the amount of a protein in the brain known as tau using an imaging procedure called Positron Emission Tomography (PET/CT). 18F-AV-1451 is a specialized radioactive PET imaging agent that is able to detect the presence of tau in the brain. In this …

mental deterioration
alzheimer's disease
positron emission tomography
  • 29 May, 2022
  • 1 location
BEAM: Brain-Eye Amyloid Memory Study (BEAM)

The main objectives for this study are: To investigate novel, non-invasive ocular measurements including optical coherence tomography and eye tracking in a cross-sectional study of participants with various neurodegenerative dementias against standard cognitive assessments and brain imaging measures; and To assess the potential utility of ocular assessments for early detection …

mild cognitive impairment
cognitive impairment
Accepts healthy volunteers
brain imaging
parkinson's disease
  • 25 Jan, 2022
  • 5 locations