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Found 483 clinical trials
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Refining MDR-TB Treatment (T) Regimens (R) for Ultra(U) Short(S) Therapy(T)

The purpose of this study is to assess the efficacy, safety and tolerability of a combination of levofloxacin, linezolid, cycloserine and pyrazinamide (or clofazimine if resistant to pyrazinamide) treatments for 24 to 32 weeks (regimen consisted of clofazimine for 36~44 weeks) in subjects with multidrug-resistant tuberculosis (MDR-TB) compared to WHO …

linezolid
pulmonary tuberculosis
smear
rifampin
pyrazinamide
  • 0 views
  • 24 Jan, 2021
  • 13 locations
None
Refining MDR-TB Treatment (T) Regimens (R) for Ultra(U) Short(S) Therapy(T)-PLUS

The purpose of this study is to assess the efficacy, safety and tolerability of a combination of bedaquiline, linezolid, cycloserine, clofazimine and pyrazinamide treatments guided by PZA sensitivity for 24 to 36 weeks in subjects with fluoroquinolone-resistant MDR-TB .

  • 0 views
  • 29 Jan, 2021
  • 14 locations
None
Cyclical Topical Wound Oxygen Therapy (TWO2) in the Treatment of Chronic Wounds

To evaluate the efficacy and clinical satisfaction of topical oxygen therapy (LOT) in chronic wounds (including patients and medical staff), and explore its possible mechanism.

  • 0 views
  • 30 Jul, 2021
  • 1 location
None
Efficacy and Safety of Cetuximab in Combination With Cisplatin Gemcitabine as First-Line Therapy in Advanced NSCLC

Lung cancer is the leading cause of cancer deaths worldwide. It is estimated that, in 2004, 173,700 new cases of lung cancer will be diagnosed in the United States alone and 164,440 deaths due to this disease will occur(13) . NSCLC accounts for approximately 80% of all lung cancers. Among …

stage iv non-small cell lung cancer
cetuximab
metastasis
measurable disease
platinum-based chemotherapy
  • 3 views
  • 07 Nov, 2020
  • 1 location
None
Neuroma Injections to Treat Restless Legs Syndrome - RCT

The purpose of this study is to determine whether, in a randomized, placebo-controlled trial, restless legs syndrome (RLS) can be caused by pinched and damaged foot nerves called neuromas.

requip
pramipexole
ropinirole
restlessness
mirapex
  • 861 views
  • 07 Nov, 2020
  • 1 location
None
Efficacy and Safety of MEDI7352 in Subjects With Painful Diabetic Neuropathy

This is a study investigating the effect of MEDI7352 on chronic pain in patients with painful diabetic neuropathy. The study incudes a screening period of up to 45 days and a 12-week treatment period during which MEDI7352 or placebo will be administered intravenously (IV) on 6 occasions, with each dose …

body mass index
chronic pain
NSAID
analgesics
painful diabetic neuropathy
  • 53 views
  • 22 Sep, 2021
  • 27 locations
None
Efficacy and Safety of Selumetinib in Adults With NF1 Who Have Symptomatic Inoperable Plexiform Neurofibromas

A global study to demonstrate the effectiveness of selumetinib in participants with NF1 who have symptomatic, inoperable plexiform neurofibromas.

  • 0 views
  • 30 Sep, 2021
  • 33 locations
None
Pediatric Long-Term Follow-up and Rollover Study

A roll-over study to assess long-term effect in pediatric patients treated with dabrafenib and/or trametinib.

trametinib
dabrafenib
  • 487 views
  • 28 Apr, 2021
  • 17 locations
None
Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma

incidence and/or severity of acute vincristine-induced peripheral neuropathy can be reduced by decreasing the dosage of vincristine in patients with the high-risk CEP72 TT genotype or by shortening the

doxorubicin
cyclophosphamide
clofarabine
intrathecal chemotherapy
minimal residual disease
  • 231 views
  • 02 Sep, 2021
  • 7 locations
None
XELOX for 4 Months Versus 6 Months in Gastric Cancer (LOMAC)

Our study aims to compare the efficacy and safety of capecitabine and oxaliplatin for 4 months versus 6 months as adjuvant chemotherapy after D2 Gastrectomy in patients with gastric cancer. Hypothesis: For gastric patients after D2 Gastrectomy, capecitabine and oxaliplatin for 4 months show noninferiority to capecitabine and oxaliplatin for …

xelox regimen
cancer chemotherapy
adjuvant chemotherapy
oxaliplatin
gastrectomy
  • 22 views
  • 22 Jan, 2021
  • 10 locations