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Found 498 clinical trials
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A First in HumanTrial to Evaluate The Safety Tolerability And Pharmacokinetics Of PF-06755347

This phase 1 single ascending dose study will provide a first in human assessment of safety and tolerability of PF-06755347 in healthy adult male subjects. The pharmacokinetics and pharmacodynamics will also be evaluated.

malignancy
administered intravenously
cancer
heart failure
  • 170 views
  • 29 Sep, 2021
  • 6 locations
None
Implementation of ABI and WIfI in Rural Health Clinics

The objective of this project is to assess the fidelity and sustainability of in improving provider performance with Ankle Brachial Index (ABI) assessment and ulcer staging with the would ischemia foot infection (WIfI) tool for new patients with lower extremity ulcers due to peripheral artery disease (PAD) and diabetes mellitus …

arteriopathy
leg ulcer
peripheral arterial diseases
ischemia
foot ulcer
  • 0 views
  • 07 May, 2021
  • 1 location
None
Longitudinal Natural History Study of Patients With Peroxisome Biogenesis Disorders (PBD)

The Peroxisome Biogenesis Disorders (PBD) are a group of inherited disorders due to defects in peroxisome assembly causing complex developmental and metabolic sequelae. In spite of advancements in peroxisome biology, the pathophysiology remains unknown, the spectrum of phenotypes poorly characterized and the natural history not yet systematically reported. Our aims …

  • 5 views
  • 26 Jan, 2021
  • 1 location
None
TEWL Biomarker Study for Diabetic Foot Ulcer Recurrence

This is a multicenter study of patients with diabetic foot ulcers (DFU) to develop and validate potential tissue-based biomarkers that predict DFU wound recurrence. Trans-epidermal water loss (TEWL) will be measured on the closed wound site and a location similar to the wound site (reference site). Participants will be enrolled …

hyperglycemia
foot ulcer
diabetic foot
diabetes
oral glucose tolerance test
  • 5 views
  • 17 Nov, 2021
  • 6 locations
None
C-myc Biomarker Study for Diabetic Foot Ulcers

This is a multi-center observational cohort study of patients with diabetic foot ulcers (DFU) to develop and validate potential tissue-based biomarkers that predict complete wound healing. Eligible and consented participants will begin standard of care treatment after collection of tissue specimens from the wound's edge. An additional tissue specimen is …

debridement
foot ulcer
diabetic foot
hemoglobin a1c
diabetes
  • 0 views
  • 12 Nov, 2021
  • 6 locations
None
Autologous Fat Grafting in the Treatment of Critical Limb Ischaemia

Critical Limb Ischaemia (CLI) is a condition characterized by chronic ischemic at-rest pain, ulcers, or gangrene for more than 2 weeks in one or both legs, attributable to objectively proven arterial occlusive disease.CLI is associated with a high risk of lower amputation, diminished quality of life and mortality. Revascularization by …

  • 0 views
  • 19 Feb, 2021
  • 1 location
None
Biorepository and Registry for Plasma Exchange Patients

Patients who have immune mediated diseases commonly undergo plasma exchange (PLEX) procedures to remove pathological substances, typically believed to be antibodies. At our facility about 400 of these procedures are performed annually on 40-60 different patients. These procedures are considered within the standard of care for these patients and are …

cell counts
immune globulin
plasma exchange
  • 0 views
  • 22 Aug, 2021
  • 1 location
None
Genetics of Pediatric-Onset Motor Neuron and Neuromuscular Diseases

The goal of this study is to establish a genetic registry of patients with early-onset motor neuron and neuromuscular diseases. The investigators will collect samples from patients with a motor neuron or a neuromuscular disorder and their family members. The samples to be collected will be obtained using minimally invasive …

neuromuscular diseases
  • 142 views
  • 20 Mar, 2021
  • 3 locations
None
EO2 Oxygen Delivery To Study Success Rate of Surgically Closed Wounds

The investigators will test the efficacy of the novel oxygen diffusion dressing allows delivery tissue oxygenation via TransCu O2 Oxygen Delivery System for use in caring for patients with surgically closed wounds. The investigators hypothesize that using this novel oxygen diffusion dressing will reduce the likelihood of necrotic tissue as …

scar
  • 19 views
  • 29 Jan, 2021
  • 1 location
None
Study on the Assessment of Determinants of Muscle and Bone Strength Abnormalities in Diabetes

This project will assess the independent predictors of impaired muscle and bone strength through a longitudinal observation of a cohort of subjects with type 1 and 2 diabetes consecutively attending an outpatients diabetes clinics for the annual screening of complications.

diabetes
  • 21 views
  • 07 Oct, 2021
  • 1 location