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Found 485 clinical trials
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Longitudinal Natural History Study of Patients With Peroxisome Biogenesis Disorders (PBD)

The Peroxisome Biogenesis Disorders (PBD) are a group of inherited disorders due to defects in peroxisome assembly causing complex developmental and metabolic sequelae. In spite of advancements in peroxisome biology, the pathophysiology remains unknown, the spectrum of phenotypes poorly characterized and the natural history not yet systematically reported. Our aims …

  • 5 views
  • 26 Jan, 2021
  • 1 location
None
RECCORD (Recording Courses of Vascular Diseases) Registry

The RECording COurses of vasculaR Diseases registry (RECCORD registry) is an observational, prospective, multicentre, all-comers registry platform. In the initial phase, patients referred for endovascular revascularization of peripheral artery disease (PAD) of the lower limbs will be prospectively included and followed up for at least one year. At baseline, data …

endovascular revascularization
revascularisation
vascular disease
endovascular intervention
arteriopathy
  • 48 views
  • 12 Feb, 2021
  • 2 locations
None
A First in HumanTrial to Evaluate The Safety Tolerability And Pharmacokinetics Of PF-06755347

This phase 1 single ascending dose study will provide a first in human assessment of safety and tolerability of PF-06755347 in healthy adult male subjects. The pharmacokinetics and pharmacodynamics will also be evaluated.

administered intravenously
malignancy
cancer
heart failure
  • 168 views
  • 29 Sep, 2021
  • 6 locations
None
Genetics of Pediatric-Onset Motor Neuron and Neuromuscular Diseases

The goal of this study is to establish a genetic registry of patients with early-onset motor neuron and neuromuscular diseases. The investigators will collect samples from patients with a motor neuron or a neuromuscular disorder and their family members. The samples to be collected will be obtained using minimally invasive …

neuromuscular diseases
  • 142 views
  • 20 Mar, 2021
  • 3 locations
None
EO2 Oxygen Delivery To Study Success Rate of Surgically Closed Wounds

The investigators will test the efficacy of the novel oxygen diffusion dressing allows delivery tissue oxygenation via TransCu O2 Oxygen Delivery System for use in caring for patients with surgically closed wounds. The investigators hypothesize that using this novel oxygen diffusion dressing will reduce the likelihood of necrotic tissue as …

scar
  • 19 views
  • 29 Jan, 2021
  • 1 location
None
Dietary Supplementation in Heart Failure

A single-center, double-blind, placebo-controlled, cross-over study pilot study comparing R Drink vs. placebo in 60 heart failure patients. Half of the participants will also have diabetes mellitus. The 60 patients will be distributed among three arms. Total distance walked in six minutes and hospital readmission rates will be examined. Eligible …

calcium
diastolic heart failure
diuretics
diabetes
medical therapy
  • 24 views
  • 23 Jan, 2021
  • 1 location
None
Study on the Assessment of Determinants of Muscle and Bone Strength Abnormalities in Diabetes

This project will assess the independent predictors of impaired muscle and bone strength through a longitudinal observation of a cohort of subjects with type 1 and 2 diabetes consecutively attending an outpatients diabetes clinics for the annual screening of complications.

diabetes
  • 21 views
  • 07 Oct, 2021
  • 1 location
None
Phenotype Genotype and Biomarkers 2

The purpose of this study is to learn more about amyotrophic lateral sclerosis (ALS) and other related neurodegenerative diseases, including frontotemporal dementia (FTD), primary lateral sclerosis (PLS), hereditary spastic paraplegia (HSP), progressive muscular atrophy (PMA) and multisystem proteinopathy (MSP). More precisely, the investigator wants to identify the links that exist …

frontotemporal dementia
atrophy
primary lateral sclerosis
paraplegia
dementia
  • 0 views
  • 14 Jul, 2021
  • 4 locations
None
Registry for Adults With Plasma Cell Disorders (PCD's)

The primary purpose of this protocol is to create a registry of patients with plasma cell disorders (PCDs), including for example the cancer multiple myeloma (MM), who complete the assessment, previously known as a "geriatric assessment," as is outlined in this protocol. Secondary objectives include measuring the response rate to …

amyloidosis
gammopathy
monoclonal protein
multiple myeloma
polyneuropathy
  • 33 views
  • 26 Jan, 2021
  • 1 location
None
Exploring Immune Cell Signatures in Autoimmunity and Dry Eye Syndrome

Ocular surface disease, especially dry eye and scleritis, commonly affects patients with autoimmune diseases. Ocular surface immune cells are increased in autoimmune disease; however the full subset of immune cells activated is unknown. Recent experimental studies show that dendritic cells and T cells in the cornea are critically associated with …

lupus
meibomian gland dysfunction
erythema
systemic lupus erythematosus
burning sensation
  • 91 views
  • 25 Jan, 2021
  • 1 location