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Found 500 clinical trials
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Can Prophylactic Foraminotomy Prevent C5 Palsy

C5 palsy (C5P) is a well-known, although rare complication of cervical spine decompression surgery. In severe forms, C5P causes debilitating upper extremity weakness involving the deltoids and/or biceps brachii muscles, ultimately diminishing these patients' quality of life. Furthermore, about half of patients with C5P present with sensory deficits and/or intractable …

foraminotomy
laminoplasty
decompression surgery
weakness
cervical laminectomy
  • 32 views
  • 26 Feb, 2021
  • 1 location
None
Pudendal Nerve Block in Vaginal Surgery

The objective of this this randomized controlled study is to determine whether a pudendal nerve block at the time of vaginal surgery is associated with improved postoperative pain control and decrease opioid consumption compared to a sham pudendal nerve block in patients undergoing vaginal surgery.

postoperative pain
opioid
vaginal surgery
pain control
complete vaginectomy
  • 2 views
  • 12 Feb, 2021
  • 1 location
None
10 Years Follow-up Study of Plantar Pressure Kinetics and Kinematics in a Cohort of Patients Diagnosed With Diabetes

A combination of diabetes and neuropathy can cause an altered gait, increased tissue stiffness, limited joint mobility, muscle weakness, foot deformities, thus leading to excessive plantar pressure. The presence of an increased plantar pressure and the loss of sensation is a serious risk factor in the risk of development of …

diabetes
loss of sensation
stiffness
muscle weakness
weakness
  • 5 views
  • 26 Jan, 2021
  • 1 location
None
A Registered Cohort Study on Charcot-Marie-Tooth Disease

The aim of the study is to analyze the natural history data data from Charcot-Marie-Tooth disease and related disorders in China, to assess the clinical, genetic, epigenetic features of patients with Charcot-Marie-Tooth disease, and to optimize clinical management.

  • 1 views
  • 26 Jan, 2021
  • 1 location
None
Phenotypes Biomarkers and Pathophysiology in Hereditary Spastic Paraplegias and Related Disorders

The aim of this study is to determine the clinical spectrum and natural progression of Hereditary Spastic Paraplegias (HSP) and related disorders in a prospective multicenter natural history study, identify digital, imaging and molecular biomarkers that can assist in diagnosis and therapy development and study the genetic etiology and molecular …

  • 4 views
  • 31 May, 2021
  • 15 locations
None
Caregiver Burden and Correlation With Clinical Outcome in Spinal Cord Stimulation for Chronic Neuropathic Pain

Prospective multicentric observational trial on caregiver burden, caregiver satisfaction and clinical outcome in spinal cord stimulation for chronic neuropathic pain.

  • 0 views
  • 12 Feb, 2021
  • 2 locations
None
Tools for Therapeutic Evaluation in Charcot-Marie-Tooth Disease Type 1A: Outcome Measures and Biomarkers

This is a 2-year follow-up study of a cohort of 60 CMT1A patients. The objective is to identify markers allowing to better understand the phenotypic variability observed on patients with CMT1A, to identify predictive markers of the disease's progression and to provide validated measurement tools that can be used as …

Accepts healthy volunteers
  • 0 views
  • 14 Nov, 2021
  • 2 locations
None
Motor Learning in Individuals With Lower Limb Loss and Chronic Diabetes

Inadequate rehabilitation training after amputation can result in poor patient outcomes, injuries, and wasted healthcare resources. This is a serious public health problem due to an aging population and rising prevalence of diabetes (main cause of amputation in the U.S.). In this study, the investigators will examine the effects of …

diabetes
fatigue
fitting
  • 0 views
  • 27 Jun, 2021
  • 1 location
None
Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia

The Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia (HSP) is focused on gathering longitudinal clinical data as well as biological samples (skin and/or blood and/or saliva) from male or female patients who exhibited onset of HSP symptoms at 18 years old or younger with (1) a …

Accepts healthy volunteers
  • 0 views
  • 24 Nov, 2021
  • 1 location
None
Observational Study of Neuromuscular Function in CMT Type 1&2 and Healthy Controls

The primary aim of this study is to discover whether patients with CMT type 1 and 2 have neuromuscular junction transmission deficits. The secondary aim is to collect information of different clinical and electrophysiological test procedures to perform possible future clinical trials in CMT patients.

  • 0 views
  • 05 Aug, 2021
  • 2 locations