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Found 495 clinical trials
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A Registered Cohort Study of Immune-Mediated Neuropathies

This study will provide further insights into the natural course of the disease about Immune-Mediated Neuropathies including clinical featuresprogression, related antibody spectrum and drug treatment effect.

  • 0 views
  • 30 Mar, 2021
  • 2 locations
None
Proof-of-concept Study for BIVV020 in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

Primary Objective: Part A: Efficacy of BIVV020 across three subpopulations of CIDP patients: standard of care (SOC)-Treated, SOC-Refractory and SOC-Naive Part B:Long-term safety and tolerability of BIVV020 in CIDP Secondary Objective: -Part A: Safety and tolerability of BIVV020 in CIDP Immunogenicity of BIVV020 Efficacy of BIVV020 with overlapping SOC (SOC-Treated …

polyneuropathy
igiv
cyclosporine
immunoglobulins
prednisone
  • 7 views
  • 11 Jul, 2021
  • 8 locations
None
Coordinated Reset Spinal Cord Stimulation

The goal of this study is to evaluate whether a new spinal cord stimulation paradigm, called Coordinate Reset (CR) Stimulation, can provide equivalent or better pain relief with reduced energy requirements. The investigators will test this new stimulation paradigm in patients who are already undergoing spinal cord stimulation surgery. The …

  • 0 views
  • 18 Aug, 2021
  • 1 location
None
Effects of Single Plasma Exchange and Double Filtration Plasmapheresis (DFPP) on Peripheral Lymphocyte Phenotypes in Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy

CIDP, a rare disorder affecting young adults, causes gradual weakness of the limbs, areflexia and impaired sensory function. New CIDP phenotypes without antibodies but with modified cell profiles have been described. Treatments include corticotherapy, IVIg and plasmapheresis but the latter's action mechanisms remain unclear. Plasmapheresis supposedly removes toxic agents like …

plasma exchange
polyneuropathy
igiv
weakness
  • 0 views
  • 19 Jul, 2021
  • 1 location
None
Proof-of-concept Study for BIVV020 in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

Primary Objective: Part A: Efficacy of BIVV020 across three subpopulations of CIDP patients: standard of care (SOC)-Treated, SOC-Refractory and SOC-Naive Part B:Long-term safety and tolerability of BIVV020 in CIDP Secondary Objective: -Part A: Safety and tolerability of BIVV020 in CIDP Immunogenicity of BIVV020 Efficacy of BIVV020 with overlapping SOC (SOC-Treated …

polyneuropathy
igiv
cyclosporine
immunoglobulins
prednisone
  • 0 views
  • 03 Dec, 2021
  • 29 locations
None
Peripheral Magnetic Stimulation to Treat Patient With Post-stroke Shoulder-hand Syndrome

Shoulder-hand syndrome is a common complication following stroke, constituting of excessive pain, swelling, heat, limited range of motion, and trophic change of the affected limbs. It not only has an extensive negative impact on both physical and psychological aspects of a stroke patient's well-being, but also impose burden on the …

  • 0 views
  • 16 Nov, 2021
  • 1 location
None
10 Years Follow-up Study of Plantar Pressure Kinetics and Kinematics in a Cohort of Patients Diagnosed With Diabetes

A combination of diabetes and neuropathy can cause an altered gait, increased tissue stiffness, limited joint mobility, muscle weakness, foot deformities, thus leading to excessive plantar pressure. The presence of an increased plantar pressure and the loss of sensation is a serious risk factor in the risk of development of …

neuropathy
muscle weakness
weakness
stiffness
plantar ulcers
  • 5 views
  • 26 Jan, 2021
  • 1 location
None
Pudendal Nerve Block in Vaginal Surgery

The objective of this this randomized controlled study is to determine whether a pudendal nerve block at the time of vaginal surgery is associated with improved postoperative pain control and decrease opioid consumption compared to a sham pudendal nerve block in patients undergoing vaginal surgery.

complete vaginectomy
opioid
postoperative pain
pain control
hysterectomy
  • 11 views
  • 12 Feb, 2021
  • 1 location
None
The Pre-SPG4 Study

Study goals Prospective longitudinal data on progression in the natural course of SPG4 in presymptomatic mutation carriers prior to clinical disease onset and in early stages of disease Biomarkers providing objective measures of disease activity

  • 15 views
  • 07 Oct, 2021
  • 2 locations
None
Development of Charcot Marie Tooth Disease (CMT) Pediatric Scale for Children With CMT

The primary goal of this project is to develop and test a Charcot Marie Tooth disease (CMT) Pediatric Scale for use in evaluation in natural history CMT study.

  • 78 views
  • 26 Aug, 2021
  • 12 locations