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Found 46 clinical trials
Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA

resonance imaging (rsfMRI), (MPRAGE), diffusion weighted imaging (DWI), perfusion imaging (pCASL), and magnetic resonance spectroscopy (MRS), before, after, and 3-months post-intervention. Aim 3: To

Accepts healthy volunteers
alzheimer's disease
neurodegenerative disorders
  • 42 views
  • 14 Jul, 2022
  • 1 location
Evaluating DyNamic Myocardial Blood Flow QUantitation As a Cost Effective Care ModeL for DiabEtic Patients With Coronary Artery DiSease (NUCLEuS)

This will be a prospective randomized clinical trial comprising of n=300 diabetic patients, randomized to either dynamic (n=150) or conventional MPI (n=150) strategy. Healthcare resources utilization of each patient will be tracked. Patients will be followed up for short term outcomes and for long term outcomes.

perfusion imaging
myocardial perfusion imaging
  • 0 views
  • 10 May, 2022
  • 1 location
Parametric PET of Genitourinary Cancer

Metastatic kidney cancer is usually treated with targeted therapy or immunotherapy which is costly and has low response rate. The current standard care is to perform anatomical imaging studies after a few cycles (months) of treatment to evaluate response. This approach exposes many patients to highly toxic, high expensive treatment …

targeted therapy
sunitinib
clear cell renal cell carcinoma
cancer
metastasis
  • 0 views
  • 04 Oct, 2022
  • 1 location
New MRI Methods Applied to Heart Failure With Preserved Ejection Fraction (HFpEF)

This study's main specific aims are; To develop robust acquisition and reconstruction methods specifically for the study of microvascular cardiac remodeling with MRI which will include very innovative quantitative perfusion methods, as well as fibrosis quantification, longitudinal strain, and phase contrast imaging for flow. Test the new methods for identifying …

  • 0 views
  • 25 Jan, 2021
  • 1 location
Cardiac Sarcoidosis Randomized Trial (CHASM-CS-RCT)

Prospective randomized controlled trial comparing low dose Prednisone(or Prednisolone)/Methotrexate combination to standard dose Prednisone(or Prednisolone) in patients diagnosed with acute active clinically manifest cardiac sarcoidosis and not yet treated. The Investigators hypothesize that low dose Prednisone(or Prednisolone)/Methotrexate combination will be as effective as standard dose Prednisone(or Prednisolone), and result in …

pulmonary sarcoidosis
lymphadenopathy
prednisone
cardiac sarcoidosis
methotrexate
  • 252 views
  • 27 Feb, 2022
  • 8 locations
Development of Novel Physiological CMR Methods in Health and Disease

Physiological cardiovascular stress test plays a crucial role in the assessment of patients with suspected heart disease. There are several methods of cardiac physiological stress tests and each of them offer varied insight into cardiac physiological adaptation: passive leg raise, intra-venous fluid challenge, pharmacological stressors and physical exercise stress test. …

Accepts healthy volunteers
exercise stress test
heart disease
  • 44 views
  • 02 Mar, 2022
  • 1 location
SPECT/CT Imaging of Skeletal Muscle Perfusion

This study will use SPECT/CT imaging to assess the effect of percutaneous revascularization treatments in patients with Peripheral arterial disease and diabetes mellitus, in whom the disease can progress more quickly than in patients without diabetes.

oral glucose tolerance test
diabetes
arteriopathy
computed tomography angiography
vascular disease
  • 5 views
  • 02 Jun, 2022
  • 1 location
Imaging vs. no Testing in Asymptomatic High-risk Diabetic Patients

The aim of our study was to evaluate 1- and 3-year outcome of alternative imaging strategies in asymptomatic high-risk diabetic patients: functional stress echocardiography combined with coronary flow reserve (CFR) and strain imaging, or computed tomography (CT) angiography with direct visualization of coronary arteries, and no testing at all.

hypertension
angiography
  • 0 views
  • 29 Aug, 2021
  • 1 location
68Ga-NODAGA-RGD PET in Patients With an Occluded Coronary Artery (RGDHeart)

Background: In patients with coronary artery disease, acute or chronic coronary artery occlusion is associated with various degrees of ischemic myocardial injury and left ventricle dysfunction. The integrin αVβ3 plays a role in angiogenesis, i.e. formation of new capillaries from pre-existing blood vessels that is increased during repair of ischemic …

angina pectoris
infarct
revascularisation
myocardial infarction
unstable angina
  • 0 views
  • 08 Apr, 2022
  • 2 locations
A Pilot Study in Severe Patients With Takayasu Arteritis.

Takayasu arteritis (TAK) is a rare chronic inflammatory arteritis, which lacks an effective well-accepted intervention strategy. We classify TAK patients into 3 levels, including mild, moderate, and severe. And the biological agents tocilizumab and adalimumab are randomly prescribed in severe patients, to find out the relatively better treatment strategy, facilitating …

tocilizumab
adalimumab
  • 0 views
  • 01 Mar, 2022
  • 1 location