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Found 22 clinical trials
A Phase II Study to Test the Efficacy of AB928 (Dual Adenosine Receptor Antagonist) and AB122 (a PD1 Checkpoint Inhibitor) in Combination With Short Course Radiotherapy and Consolidation Chemotherapy for Rectal Cancer. (PANTHER)

Enrolled patients will receive upfront (week 1) short-course radiotherapy to gross pelvic disease (25Gy in 5fx) in combination with AB928 (150 mg orally, once daily as part of a continuous dose regimen). This will be followed by consolidation chemotherapy (weeks 3-20) with mFOLFOX x9 cycles in combination with AB928 and …

adenocarcinoma
pelvic radiation
folfox regimen
total mesorectal excision
  • 0 views
  • 06 May, 2022
  • 1 location
Management of LLN Metastasis in Locally Advanced Rectal Cancer: A Prospective Radiation Dose Escalation Study

In this study, locally advanced rectal cancer (LARC) patients with lateral lymph node (LLN) metastasis would be enrolled. The LLNs with short axis (SA) 5 mm are considered metastatic.The safety of neoadjuvant chemoradiotherapy(nCRT) with a booster dose to 58Gy had been initially demonstrated in our previous research. The effective and …

pelvic mri
chemoradiotherapy
adenocarcinoma
metastasis
carcinoma
  • 0 views
  • 05 Oct, 2021
  • 1 location
Clinical Response and Toxicity of Hypo-fractionated Chemoradiotherapy in Cervix Cancer

Uterine cervix cancer can be treated definitively with concurrent chemoradiation (external beam radiotherapy and chemotherapy) followed by high dose rate brachytherapy. Treatment duration can be shortened by increasing the dose per fraction of treatment which can reduce costs and patient exposure. The aim of our study is to determine the …

Accepts healthy volunteers
  • 0 views
  • 21 Oct, 2021
  • 1 location
BReak Interval Delayed Surgery for Gastrointestinal Extraperitoneal Rectal Cancer (BRIDGE)

This is a randomized multicentric clinical trial in patients affected by resectable rectal cancer, cT2N1-2, cT3N0-2, MRF -, aiming to evaluate the impact of the interval between chemoradiotherapy and surgery on the pathological response. Patients will undergo a neoadjuvant chemoradiotherapy treatment and those achieving a major or complete clinical and …

adenocarcinoma
chemoradiotherapy
  • 0 views
  • 25 Mar, 2022
  • 1 location
Watch and Wait as Treatment for Patients With Rectal Cancer (WoW)

A national cohort study with all patients scheduled for neoadjuvant treatment with (chemo)radiotherapy or short course radiotherapy with delayed surgery 6-8 weeks) for rectal cancer staged as cT4bNX/anycTanycN and cMRF+/anycTanycN and lateral lymph nodes on MRI (and patients that have been offered short course raditotherapy with delayed surgery due to …

cancer
pelvic mri
endoscopy
rectal carcinoma
  • 31 views
  • 13 Feb, 2022
  • 2 locations
Non-operative Management for Locally Advanced Rectal Cancer (NOM)

This is a 5 year Phase II study to evaluate the safety of non-operative management (NOM) in patients with low rectal cancer (LRC) who achieve a complete clinical response (cCR) following chemoradiotherapy (CRT). The safety of NOM will be evaluated by assessing (i) rate of local re-growth and (ii) rate …

chemoradiotherapy
fluorouracil
cancer
rectal carcinoma
capecitabine
  • 6 views
  • 07 Oct, 2022
  • 1 location
The French National Reference Centre of GTD

pelvic US with Doppler, pelvic MRI, thoraco-abdominal CT-scan with chest radiography if pulmonary nodules are present and brain MRI, is planned to determine the adequate treatment. Very

choriocarcinoma
human chorionic gonadotrophin
hydatidiform mole
chest radiography
trophoblastic disease
  • 21 views
  • 21 Jan, 2021
  • 1 location
Pilot Study of Measurement Agreement Between Morphological and Diffusion Tensor Imaging MRI for Pelvic Nerve Cartography (NERVWATCH)

The investigators hypothesize that diffusion tensor imaging (DTI) will produce a similar map of autonomic pelvic innervation to that obtained using 3D morphological MRI sequences

  • 0 views
  • 12 Oct, 2022
  • 1 location
CLassification of Axial SpondyloarthritiS Inception Cohort (CLASSIC)

A joint meeting of the ASAS (Assessment of Spondyloarthritis Internal Society) and SPARTAN (Spondyloarthritis Research and Treatment Network) executive boards recommended that the existing ASAS classification criteria for spondyloarthritis undergo further validation. SPARTAN is in charge of conducting a a prospective study of a North American cohort of patients presenting …

chronic pain
axial spondyloarthritis
back pain
  • 426 views
  • 21 Feb, 2022
  • 14 locations
STereotactic sAlvage Radiotherapy for Macroscopic Prostate Bed Recurrence After prostatectomy-a Prospective Observational Study (STARR)

STereotactic sAlvage Radiotherapy for macroscopic prostate bed Recurrence after prostatectomy (STARR trial) is a prospective observational study aimed to assess outcome after Stereotactic salvage radiotherapy (SSRT) for macroscopic prostate bed recurrence after radical prostatectomy.

  • 0 views
  • 04 Oct, 2022
  • 1 location