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Found 21 clinical trials
Anti-PD-1 Antibody Combined With Pegaspargase in the Treatment of Advanced Stage NK/T-cell Lymphoma

This open-label, single arm study will evaluate the efficacy and safety of anti-PD-1 antibody in combination with pegaspargase in treatment of newly diagnosed advanced stage NK/T-cell lymphoma

  • 1 views
  • 23 Jan, 2021
  • 1 location
GPED Regimen for Relapsed/Refractory or Advanced ENKTCL

The purpose of this study is to evaluate the efficacy and safety of gemcitabine, pegaspargase, etoposide, and dexamethasone (GPED) in the treatment of Relapsed/Refractory or advanced NK/T-cell

  • 0 views
  • 24 Jan, 2021
  • 1 location
Sintilimab With P-GemOx Regimen for Newly Diagnosed Advanced Extranodal Natural Killer/T-cell Lymphoma Nasal Type

The purpose of this multi-center,single arm,phase clinical trail is to determine the safety and efficacy of Sintilimab with P-GemOx (pegaspargase, gemcitabine and oxaliplatin) regimen for newly

  • 0 views
  • 23 Jan, 2021
  • 1 location
Tislelizumab Combined Treatment in Refractory Extranodal NK/T-cell Lymphoma

Natural killer/T-cell lymphoma (NKTCL) patients with relapsed/refractory disease had very poor outcome. Anti-PD-1 antibody showed promising results in response, but but the complete remission rate of was low. Some anti-PD-1 antibody based regimen showed higher and deeper response in NKTCL patients.

  • 0 views
  • 03 Oct, 2021
  • 1 location
A French Protocol for the Treatment of Acute Lymphoblastic Leukemia (ALL) in Children and Adolescents (CAALL-F01)

death. But indeed the use of ASNase varies between protocols considering the different brands, the dose and the administration modalities. Oncaspar (PEGylated E. coli asparaginase, pegaspargase) was

asparaginase
induction therapy
lymphoid leukemia
pegaspargase
  • 0 views
  • 26 Jan, 2022
  • 28 locations
Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents

of dosing a chemotherapy drug called pegaspargase (which is part of the standard treatment for ALL) based on checking levels of the drug in the blood and adjusting the dose based on the levels.

cyclophosphamide
dasatinib
adult t-cell leukemia/lymphoma
conjugated bilirubin
etoposide
  • 12 views
  • 26 Mar, 2022
  • 7 locations
A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia

. Chemotherapy drugs, such as vincristine, dexamethasone, prednisone, prednisolone, pegaspargase, methotrexate, cytarabine, mercaptopurine, doxorubicin, cyclophosphamide, and thioguanine, work in different ways

cyclophosphamide
flow cytometry
prednisone
lymphoblastic lymphoma
blinatumomab
  • 92 views
  • 15 May, 2022
  • 105 locations
Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy

, vincristine, and pegaspargase work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. This trial will also

cyclophosphamide
flow cytometry
prednisone
lymphoblastic lymphoma
inotuzumab
  • 56 views
  • 13 May, 2022
  • 116 locations
Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma

lymphoblastic leukemia (T-ALL) and T-lymphoblastic lymphoma (T-LLy) by optimizing pegaspargase and cyclophosphamide treatment and by the addition of new agents in patients with targetable genomic abnormalities

cyclophosphamide
thioguanine
dasatinib
adult t-cell leukemia/lymphoma
flow cytometry
  • 278 views
  • 11 May, 2022
  • 7 locations
Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

This randomized phase III trial studies how well imatinib mesylate and combination chemotherapy work in treating patients with newly diagnosed Philadelphia chromosome positive acute lymphoblastic leukemia. Imatinib mesylate may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, work …

acute leukemia
glomerular filtration rate
conjugated bilirubin
prednisolone
left ventricular fractional shortening
  • 305 views
  • 06 Apr, 2022
  • 166 locations