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Found 595 clinical trials
CT-based Radiomic Algorithm for Assisting Surgery Decision and Predicting Immunotherapy Response of NSCLC

The purpose of this study was to investigate whether the combined radiomic model based on radiomic features extracted from focus and perifocal area (5mm) can effectively improve prediction performance of distinguishing precancerous lesions from early-stage lung adenocarcinoma, which could assist clinical decision making for surgery indication. Besides, response and long …

lung carcinoma
cancer
ct scan
ct scan chest
adenocarcinoma
  • 0 views
  • 24 Jan, 2021
  • 2 locations
Chromosomal Instability as a Surrogate Biomarker of Drug Resistance in Immunotherapy for Lung Cancer Patients

PD1, as an immune checkpoint inhibitor, has provided a new therapeutic approach for patients with cancer, including patients. Although immunotherapy has proven effective, most patients do not benefit from it because of a large proportion which developing primary and acquired resistance. However, there is still a lack of accurate and …

ROS1
lung carcinoma
cancer
antineoplastic
lung cancer
  • 0 views
  • 23 Jan, 2021
  • 1 location
LIFE - Lung Cancer Immunotherapy Frailty Effect

The LIFE study (Lung cancer, Immunotherapy, Frailty, Effect) is investigating the unselected 'real life' non-small cell lung cancer (NSCLC) population treated with immune checkpoint inhibition.

  • 0 views
  • 27 Jan, 2021
  • 1 location
Tumor Growth Rate (TGR) Predicts Clinical Outcomes for Advanced Non-small Cell Lung Cancer Undergoing Immunotherapy.

We hypothesized that TGR could serve as an early predictor of outcomes for aNSCLC patients undergoing immune checkpoint inhibitors (ICIs). A retrospective analysis was conducted to investigate the association of TGR with response and long-term survival of aNSCLC patients undergoing ICI therapy.

  • 0 views
  • 25 Mar, 2021
  • 3 locations
Anti-angiogenic Agents Plus Anti-PD-1 Antibodies for uHCC

Combination treatment with antiangiogenic agents and anti-programmed cell death protein 1 (PD-1) antibodies have shown high anti-tumor efficacy for patients with unresectable or advanced hepatocellular carcinoma (uHCC). In this single-center cohort study, we are aiming to (1) evaluate the clinical effectiveness in real-world patients, especially for Chinese patients, most of …

  • 0 views
  • 27 Jan, 2021
  • 1 location
Nivolumab in mRCC Patients: Treg Function T-cell Access and NK Interactions to Predict and Improve Efficacy

The project aims to identify Nivolumab predictive biomarkers in metastatic renal cancer patients through functional evaluation of peripheral Tregs and NKs. Moreover the efficacy of new CXCR4 antagonists (PCT/IB2011/000120/ EP2528936B1/ US2013/0079292A1) will be ex vivo evaluated in modulating Tregs and NKs function

carcinoma
cancer
everolimus
kidney cancer
clear cell renal cell carcinoma
  • 0 views
  • 25 Jan, 2021
  • 1 location
WGA in Platinum-refractory HNSCC Underwent Nivolumab

To choose a subgroup who could clearly benefit from Nivolumab, we are proposing a prospective observational study. Whole-genome study (WGS) analysis will be performed on archived cancer tissues from patients who were (1) cisplatin-refractory and subsequently (2) received Nivolumab (at least 4 doses) and (3) had completed imaging response evaluation …

nivolumab
cancer
  • 1 views
  • 22 Jan, 2021
  • 1 location
Gut and Intratumoral Microbiome Effect on the Neoadjuvant Chemotherapy-induced Immunosurveillance in Triple Negative Breast Cancer

The probability of pCR in TNBC patients receiving standard of care neoadjuvant chemotherapy treatment is associated with the dominance of specific intestinal and intratumoral microbiota that promote anti-tumor immunosurveillance.

triple negative breast cancer
HER2
erbb2
cancer
breast cancer
  • 9 views
  • 24 Jan, 2021
  • 2 locations
Prediction of the Efficacy of ctDNA in Immunotherapy for Advanced Gastric Cancer

Gastric cancer is one of the common malignant tumors in China, with relatively high incident rate and mortality among the population. Surgery is the conventional treatment option for early and intermediate-stage stage gastric cancer, but postoperative relapse is the major issue. Circulating tumor DNA (ctDNA) is tumor-derived fragmented DNA with …

cancer chemotherapy
gastric cancer
cancer
  • 0 views
  • 23 Jan, 2021
BIOREN (Predictive BIOmarkers in Metastatic RENal Cancer)

The BIOREN project aims are to characterize the genetic background of renal cell carcinomas and their immune environment, to try and identify biomarkers of response and to better understand the mechanisms of resistance to nivolumab in renal cancer.

  • 0 views
  • 18 Feb, 2021
  • 1 location