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Found 39 clinical trials
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Double blind, randomized, historical control study of the safety and efficacy of Eslicarbazepine Acetate Monotherapy in subjects with partial epilepsy not well controlled by current antiepileptic drugs

Double blind, randomized, historical control study of the safety and efficacy of Eslicarbazepine Acetate Monotherapy in subjects with partial epilepsy not well controlled by current antiepileptic

  • 736 views
  • 08 Nov, 2020
  • 1 location
EEG Monitoring for Refractory Status Epilepticus

This is a prospective randomized study to investigate the yield of continuous electroencephalogram (cEEG), as a diagnostic tool in intensive care unit (ICU), for patients with refractory status epilepticus (RSE) and the contribution of this test to the patient final outcome, compared with standard medical care. Specifically, the hypothesis is …

  • 0 views
  • 31 Jul, 2021
  • 1 location
In-depth Investigation of Brain Network Interactions (BNI)

Brain stimulation is a means to potentially remediate symptoms in a range of neurological and psychiatric diseases, however, precise targeting of stimulation is necessary to ensure efficacy. The proposed project will use recent advances in functional magnetic resonance imaging to delineate distributed brain networks within individuals, and use these network …

  • 124 views
  • 23 Mar, 2022
  • 1 location
Neurophysiologically Based Brain State Tracking and Modulation in Focal Epilepsy

Researchers are trying to determine if tracking seizure occurrence, seizure probability, behavioral state, cognition, and mood can be achieved using an implantable brain sensing and stimulation device (Medtronic RC+S Summit) coupled to an external, handheld, patient assistant device (PAD) with capability for patient interaction (patient data input). The system (RC+S …

electroencephalogram
electrocorticogram
temporal lobe epilepsy
seizure medication
generalized seizure
  • 11 views
  • 25 Mar, 2022
  • 1 location
MR-Guided Focused Ultrasound in the Treatment of Focal Epilepsy (EP001)

The purpose of this study is to evaluate the feasibility, safety, and initial effectiveness of Exablate thermal ablation of a focal epileptic target area in the brain of patients suffering from medication-refractory epilepsy, using the Exablate transcranial system to produce multiple sonications targeted in the focus of interest. The investigators …

  • 0 views
  • 26 Jan, 2022
  • 4 locations
Priming the Epileptic Brain: tVNS to Improve Efficacy of add-on AED in Patients With Focal Epilepsy (PREP)

The most prevalent neurological disorder with also immense burden of disease, epilepsy, is in over 30 percent of patients difficult to treat. The ideal treatment regime would give complete control of disease in an early stage, not only for patient well-being, but also to prevent the onset of persistent pathologic …

antiepileptics
anti-epileptic drug
brivaracetam
  • 0 views
  • 22 Mar, 2022
  • 1 location
A Study of Lu AG06466 in Participants With Treatment Resistant Focal Epilepsy

The main purpose of this study is to investigate effects of Lu AG06466 on seizure activity after increasing daily doses during 4 weeks in participants with an implanted responsive neurostimulation system.

seizure
anti-epileptic drug
antiepileptics
  • 0 views
  • 14 May, 2022
  • 1 location
Diffusion MRI Methods to Minimize Postoperative Deficits in Pediatric Epilepsy Surgery

) by precisely localizing eloquent white matter pathways in children and adolescents with drug-resistant focal epilepsy. This new imaging approach, which will acquire a DWMRI scan before pediatric

seizure
Accepts healthy volunteers
epilepsy surgery
  • 0 views
  • 06 May, 2022
  • 1 location
Dose-Escalation Study of Cenobamate (YKP3089) in Pediatric Subjects With Partial-Onset Seizures

The primary objective of this study is to assess the pharmacokinetics of cenobamate (YKP3089) in pediatric subjects with partial-onset (focal) seizures following single and multiple-dosing.

seizure
antiepileptics
electroencephalogram
ketogenic diet
  • 0 views
  • 06 May, 2022
  • 5 locations
Safety and Efficacy Extension Study of Cenobamate in Pediatric Subjects 2-17 Years of Age With Partial-onset (Focal) Seizures

Primary objective: To evaluate the safety and tolerability of cenobamate in pediatric subjects 2-17 years of age with partial-onset (focal) seizures

  • 0 views
  • 03 May, 2022
  • 1 location