Found 412 clinical trials
Parkinson's Research With Inclusion, Diversity and Equity (PRIDE)
The purpose of this study is to identify the health and healthcare needs of LGBTQIA+ and non LGBTQIA+ communities living with Parkinson's disease.
- 2 views
- 24 Oct, 2022
- 1 location
Subthalamic Nucleus Deep Brain Stimulation in Speech Study (SiSS)
Parkinson's disease (PD) patients treated with deep brain stimulation (DBS) of the subthalamic nucleus (STN) have unpredictable and varied speech outcomes after this treatment. Our research will prospectively document speech performance before, during and 6- and 12-months after STN-DBS in 80 surgically treated patients and compared with 40 non-surgical controls …
- 0 views
- 04 Oct, 2022
- 1 location
Perspectives on Healthcare Access and Equity of People With Parkinson's Disease Identifying as LGBTQ+ (LGBTQ+_PD)
Study Rationale: Older adults who identify as lesbian, gay, bisexual, transgender, or queer (LGBTQ+) have worse health than non-LGBTQ+ older adults. They and their care partners face greater barriers to getting healthcare and support from friends and family. This is because of lifelong stigma, discrimination, and isolation often separated from …
- 0 views
- 12 Oct, 2022
- 1 location
A Novel Measurement Concept to Objectively Quantify Severity of Vocal and Speech Related Symptoms Associated With Parkinson's Disease (Voice-PD)
The aim of this research program is to develop and validate a smartphone app-based digital measurement concept that: Objectively quantifies the severity of Parkinson's Disease (PD) related vocal and speech symptoms; Accurately and sensitively identifies vocal and speech abnormalities associated with the prodromal stage of PD.
- 0 views
- 24 Oct, 2022
- 1 location
Longitudinal Investigation of I2BS in PD (FOX_2)
In this study, the researchers aim to find a biomarker of PD. Using imaging scans called Positron Emission tomography (PET), Single Photon Emission Computed Tomography (SPECT), and Magnetic Resonance Imaging (MRI). The PET and SPECT scans use small amounts of radiation and specific compounds called tracers, to study chemical changes …
- 4 views
- 16 Mar, 2023
- 1 location
Molecular Imaging of Inflammation in Parkinson's Disease Using LPS and TSPO-PET/MR
It is not known what causes Parkinson's disease and what makes it worsen over time. Research conducted in the past few years has highlighted the possible role of inflammation on this process but its actual mechanisms are still obscure. In this study, the investigators aim to gain understanding on how …
- 0 views
- 17 Mar, 2023
- 1 location
Open-label Trial in Parkinson's Disease (PD) (TEMPO-4)
The purpose of this study is to evaluate the safety and efficacy of long-term administration of flexible doses of tavapadon in participants with Parkinson's Disease.
- 1 views
- 31 Mar, 2023
- 61 locations
A Study to Compare the Safety and Efficacy of Dysport® and Botox® in Adults With Upper Limb Spasticity. (DIRECTION)
This study is aiming to demonstrate the non-inferiority of AbobotulinumtoxinA (aboBoNT-A) versus OnabotulinumtoxinA (onaBoNT-A) as the primary safety endpoint, and the superiority of aboBoNT-A over onaBoNT-A with respect to duration of response as the key secondary efficacy endpoint when used at optimal doses according to approved prescribing information of each …
- 92 views
- 23 Aug, 2023
- 60 locations
Study to Compare the Efficacy and Safety of NT 201 (Botulinum Toxin) With Placebo for the Treatment of Lower Limb Spasticity Caused by Stroke or Traumatic Brain Injury (PATTERN)
The purpose of this study is to determine whether a single treatment with administration of 400 Units NT 201 (botulinum toxin) is superior to placebo (no medicine) for the treatment of lower limb spasticity caused by stroke or traumatic brain injury (Main Period). Participants will be assigned to the treatment …
- 162 views
- 28 Aug, 2023
- 49 locations
Efficacy and Safety of Astragalus for Non-motor Symptoms of α-Synucleinopathy
α-Synucleinopathy is a cluster of neurodegenerative disease with motor and non-motor symptom. However, there is still a lack of research on the treatment for non-motor symptoms of α-synucleinopathy, especially autonomic dysfunctions such as orthostatic hypotension. Efficacy and safety of astragalus for non-motor symptoms of α-synucleinopathy will be assessed by an …
- 0 views
- 20 Sep, 2023
- 1 location