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Found 43 clinical trials
Consequences of Mutations in the SPG7 Gene at the Heterozygous State

responsible for spastic paraplegia type 7. Although spastic paraplegia type 7 is considered to be a recessive disease, some clinical observations also point to a detrimental effect of a variant in SPG7 in the

  • 07 Jan, 2022
  • 1 location
A Clinical Pharmacological Study of MT-3921 in Subjects With HTLV-1 Associated Myelopathy (HAM)

The purposes of this study is to assess the safety, tolerability, and pharmacokinetics of MT-3921 in subjects with Human T-cell Leukemia Virus Type 1 (HTLV-1)-Associated Myelopathy(HAM). Subjects meeting eligibility criteria will enter the 6-month double-blind period. Subjects will be randomized in a 2:1 ratio to receive MT-3921 or placebo in …

  • 26 May, 2022
  • 1 location
Effect of Overground Gait Training Using a Torgue-Assisted Exoskeletal Wearable Device on Ambulatory Function in Subacute Stroke Patients

incomplete paraplegia caused by spinal cord injury. Nevertheless, lack of studies have reported on the effect of gait training using an exoskeletal wearable robot in subacute stroke patients.

  • 22 Dec, 2021
  • 1 location
Brain Computer Interface: Neuroprosthetic Control of a Motorized Exoskeleton (BCI)

The BCI project falls within the very broad field of brain machine interfaces. Its multiple applications include the compensation of motor deficits. The subject of the present protocol is the first test of the system in man on the compensation of motor deficits by an epidural brain implant enabling an …

  • 22 Oct, 2022
  • 1 location
A Clinical Study of the Safety and Efficacy of the Relay Thoracic Stent-Graft in Patients With Thoracic Aortic Pathologies

A Phase II study to evaluate the safety and efficacy of the Relay Stent Graft in patients with descending thoracic aneurysms.

  • 08 Nov, 2020
  • 1 location
Chest-Up: Obtaining Safe Positioning for Thoracic Surgery

Thoracotomy surgeries, both open and video assisted, are often carried out in the lateral decubitus position to optimize surgical access to the operative side. However, this position is also associated with mechanical injuries of the shoulder joint ligaments and pulling on the structures of the brachial plexus. The neck is …

thoracic surgery
  • 21 Oct, 2022
  • 1 location
Sterile Amniotic Fluid Filtrate Epidural Injection.

There is a large population of patients with lumbosacral radicular pain due to spinal stenosis who do not respond to physical therapy or oral medication management, yet wish to avoid spinal surgery or are simply not candidates due to medical co-morbidity. Given the natural history of lumbar spinal stenosis, these …

  • 06 Jan, 2022
  • 1 location
Spinal Cord Stimulation Therapy for Hereditary Spastic Paraplegias Patients

function and gait in patients with pure Hereditary Spastic Paraplegias.

  • 22 Mar, 2022
  • 1 location
Effects of FES-Rowing in Paraplegia (FES-ROW)

population of adults with traumatic paraplegia.

  • 06 Apr, 2021
  • 2 locations
The preSPG4 Study - Studying the Prodromal and Early Phase of SPG4

Study goals Prospective longitudinal data on progression in the natural course of SPG4 in presymptomatic mutation carriers prior to clinical disease onset and in early stages of disease Biomarkers providing objective measures of disease activity

  • 04 Oct, 2022
  • 1 location