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Found 330 clinical trials
A Study of Belzutifan (MK-6482) Versus Everolimus in Participants With Advanced Renal Cell Carcinoma (MK-6482-005)

The primary objective of this study is to compare belzutifan to everolimus with respect to progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) as assessed by Blinded Independent Central Review (BICR) and to compare everolimus with respect to overall survival (OS). The hypothesis is …

carcinoma
kinase inhibitor
growth factor
tyrosine
programmed cell death 1 ligand 1
  • 168 views
  • 04 Mar, 2021
  • 147 locations
Substudy 03A: A Study of Immune and Targeted Combination Therapies in Participants With First Line (1L) Renal Cell Carcinoma (MK-3475-03A)

Substudy 03A is part of a larger research study that is testing experimental treatments for renal cell carcinoma (RCC). The larger study is the umbrella study (U03). The goal of substudy

  • 0 views
  • 18 Feb, 2021
  • 9 locations
Substudy 03B: A Study of Immune and Targeted Combination Therapies in Participants With Second Line Plus (2L+) Renal Cell Carcinoma (MK-3475-03B)

Substudy 03B is part of a larger research study that is testing experimental treatments for renal cell carcinoma (RCC). The larger study is the umbrella study (U03). The goal of substudy

  • 0 views
  • 18 Feb, 2021
  • 9 locations
A Study of Belzutifan (MK- 6482) in Participants With Advanced Renal Cell Carcinoma (MK-6482-013)

This study will compare the efficacy and safety of two doses of belzutifan in participants with advanced renal cell carcinoma (RCC) with clear cell component after prior therapy. The

carcinoma
karnofsky performance status
kinase inhibitor
growth factor
programmed cell death 1 ligand 1
  • 0 views
  • 03 Mar, 2021
  • 31 locations
A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011)

This study will compare the efficacy and safety of belzutifan + lenvatinib versus cabozantinib in participants with advanced renal cell carcinoma (RCC) with clear cell component after prior

  • 0 views
  • 04 Mar, 2021
  • 9 locations
A Safety and Efficacy Study Evaluating CTX130 in Subjects With Relapsed or Refractory Renal Cell Carcinoma

This is a single-arm, open-label, multicenter, Phase 1 study evaluating the safety and efficacy of CTX130 in subjects with relapsed or refractory renal cell carcinoma.

carcinoma
karnofsky performance status
  • 25 views
  • 17 Feb, 2021
  • 7 locations
89Zr-TLX250 for PET/CT Imaging of ccRCC- ZIRCON Study

89Zr-TLX250 is under clinical development as a diagnostic agent targeting clear cell renal cell carcinoma.

nephrectomy
pet scan
clear cell renal cell carcinoma
carcinoma
  • 21 views
  • 03 Mar, 2021
  • 38 locations
Renal Adjuvant MultiPle Arm Randomised Trial

RATIONALE: The current global standard of care after nephrectomy for localised RCC therefore remains active monitoring (i.e., observation by clinical and radiological means). 30-40% patients

carcinoma
tremelimumab
neutrophil count
ct scan
metastasis
  • 60 views
  • 25 Jan, 2021
  • 35 locations
Bevacizumab and Interleukin-2 in Treating Patients With Metastatic Kidney Cancer

RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of tumor cells by blocking blood …

bevacizumab
arrhythmia
carcinoma
metastasis
cervical carcinoma in situ
  • 17 views
  • 07 Nov, 2020
  • 2 locations
An Investigation of Kidney and Urothelial Tumor Metabolism in Patients Undergoing Surgical Resection and/or Biopsy

The purpose of this study is to understand the metabolism of cancers involving the kidney, including renal cell carcinomas and urothelial cell carcinomas, and how kidney cancers use different

  • 0 views
  • 26 Jan, 2021
  • 1 location