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Found 323 clinical trials
Immune Related-adverse Events in Patients Receiving Immune Checkpoint Inhibitors

The recent introduction of anti-PD-1 (nivolumab and pembrolizumab) and anti- PD-L1 (atezolizumab, durvalumab, avelumab) immune checkpoint inhibitors revolutionized oncological guidelines. Durable responses and prolongation of survival with these agents come at the price of the development of immune related adverse events (irAEs). Innovative tools are required in order to manage …

nivolumab
squamous cell carcinoma
advanced renal cell carcinoma
pembrolizumab
histological diagnosis
  • 3 views
  • 23 Jan, 2021
  • 2 locations
Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome

BAP1 mutation such as mesothelioma, renal cell carcinoma, cholangiocarcinoma, hepatocellular carcinoma, meningioma and basal cell carcinoma.

  • 0 views
  • 19 Mar, 2021
  • 1 location
Myeloid Derived Suppressor Cells Clinical Assay in Finding Kidney Cancer

This pilot research trial studies the use of the Myeloid Derived Suppressor Cells Clinical Assay in finding and monitoring kidney cancer. Studying samples of blood and urine from patients with kidney cancer in the laboratory may aid doctors in the early detection of cancer, monitor tumor response to therapy, detect …

carcinoma
systemic therapy
kidney cancer
metastatic renal cell carcinoma
cancer
  • 5 views
  • 23 Jan, 2021
  • 1 location
Novel Mechanisms and Predictors of VEGF Receptor Inhibitor- or Immune Checkpoint Inhibitor-Associated Hypertension and Cardiovascular Disease

The purpose of this study is to understand the effect of vascular endothelial growth factor tyrosine kinase (VEGF) inhibitor, immune checkpoint-inhibitor (ICI), and combination treatment on blood pressure and blood vessel function.

tyrosine
cancer
primary cancer
vegf
cardiovascular disease
  • 2 views
  • 25 Jan, 2021
  • 1 location
BIOREN (Predictive BIOmarkers in Metastatic RENal Cancer)

The BIOREN project aims are to characterize the genetic background of renal cell carcinomas and their immune environment, to try and identify biomarkers of response and to better understand the

  • 0 views
  • 18 Feb, 2021
  • 1 location
To Establish a Reproducible Organoid Culture Model With Human Kidney Cancer

been increased by 46% compared to 2007.Within the broad classification of kidney cancers, renal cell carcinoma (RCC) accounts for approximately 85% of all cases and greater than 90% of all renal

  • 0 views
  • 26 Jan, 2021
  • 1 location
Fear of Cancer Recurrence in Genitourinary Cancer

To perform an analysis of independent predictors of fear of cancer recurrence in patients with malignant genitourinary diseases and their impact on quality of life and survival

cancer
  • 0 views
  • 26 Jan, 2021
  • 1 location
TDM for Optimized Outcome in Patients With mRCC.

The purpose of this observational study is to assess the role of plasma concentration monitoring of treatment drugs for patients with metastatic renal cell carcinoma (mRCC) in terms of efficacy

  • 0 views
  • 27 Jan, 2021
  • 3 locations
Long-term Non-interventional Observational Study Following Treatment With Fate Therapeutics FT500 Cellular Immunotherapy

Subjects who previously took part in the FT500-101 study and received allogeneic NK cell immunotherapy will take part in this long term follow-up study. Subjects will automatically enroll into study FT-003 once they have withdrawn or complete the parent interventional study. The purpose of this study is to provide long-term …

  • 0 views
  • 23 Jan, 2021
  • 3 locations
Appropriate Dosing to Optimise Personalised Cancer Treatments

This is a pilot study to assess feasibility of dried blood spot (DBS) samples for pharmacokinetic measurements of targeted anti-cancer drugs in oncology patients such as patients with BRAF-mutant melanoma receiving targeted treatment with BRAF and MEK inhibitors.

BRAF
advanced renal cell carcinoma
KIT
carcinoma
cancer
  • 0 views
  • 25 Jan, 2021
  • 1 location