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Found 66 clinical trials
Featured trial
Preventing Alzheimer's With Cognitive Training (PACT)

Dementia is the most expensive medical condition in the US and increases in prevalence with age. More than 5 million Americans have Alzheimer's disease, the most common form of dementia. Mild cognitive impairment is a transitional stage between normal cognitive aging and Alzheimer's disease or another type of dementia, and …

dementia
mild cognitive impairment
Accepts healthy volunteers
cognitive impairment
cognitive stimulation
  • 1 views
  • 28 Oct, 2022
  • 5 locations
Developing and Testing a COVID-19 Vaccination Acceptance Intervention (CoVAcS)

The COVID-19 pandemic has resulted in significant loss of life and suffering with total case and death counts increasing daily, particularly with the emergence of the delta variant. COVID-19 vaccines have proven highly effective in preventing severe illness, hospitalization, and death. Nevertheless, according to VA data sources, only 56% of …

  • 0 views
  • 29 Apr, 2022
  • 1 location
Active Surveillance of Papillary Thyroid Microcarcinoma (PMCAS)

microcarcinoma (PTMC). Patients with a 1.5 cm or smaller thyroid nodule(s) with papillary thyroid carcinoma will be eligible for the study.

  • 5 views
  • 04 Oct, 2022
  • 1 location
Neoadjuvant Therapy Study Guided by Drug Screening in Vitro for Human Epidermal Growth Factor Receptor 2 (HER2) Negative Early Breast Cancer Patients

Neoadjuvant treatment is an important treatment for early breast cancer patients. Patients with triple negative subtype who achieved pCR after neoadjuvant treatment would have longer survival. The neoadjuvant treatment for her2 negative patient was chemotherapy with combined drugs. However, not all patients benefit from chemotherapy but suffer from chemotherapy-related side …

  • 0 views
  • 19 Apr, 2022
  • 1 location
A Long-Term Safety Study of PTC923 in Participants With Phenylketonuria

The main purpose of this study is to evaluate the long-term safety of PTC923 in participants with phenylketonuria, and to evaluate the changes from baseline in dietary phenylalanine (Phe)/protein consumption.

total protein
phenylalanine
  • 0 views
  • 07 Oct, 2022
  • 2 locations
Collaborative Specialty Care for Gulf War Illness

Gulf War Veterans (GWVs) with Gulf War Illness (GWI) do not receive the care they should in the Veterans Affairs (VA). The investigators' data show 70% of GWVs with Gulf War Illness (GWI) do not receive treatment recommendations for their GWI and 78% are NOT very satisfied with their care. …

  • 0 views
  • 21 Mar, 2022
  • 1 location
LITES Task Order 0005 Prehospital Airway Control Trial (PACT) (PACT)

The Prehospital Airway Control Trial (PACT) is a proposed 5 year, open label, multi-center, stepped-wedge randomized trial comparing airway management strategies of prehospital trauma patients

  • 2 views
  • 15 Jun, 2022
  • 14 locations
No Drainage During Transoral Endoscopic Thyroidectomy Vestibular Approach(TOETVA)

This study evaluates the viability and safety of no drainage tube placement during transoral endoscopic thyroidectomy vestibular approach in treatment of patients with papillary thyroid

carcinoma
metastasis
  • 0 views
  • 13 Jul, 2022
  • 1 location
A Randomized Open-Label Phase III Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Subjects With Metastatic or Locally Advanced Unresectable Urothelial Cancer (TROPiCS-04)

The primary objective of this study is to assess overall survival (OS) with sacituzumab govitecan-hziy in comparison with treatment of physician's choice (TPC) in participants with metastatic or

antineoplastic
carboplatin
neuropathy
vinflunine
chemoradiation
  • 2 views
  • 21 Oct, 2022
  • 186 locations
A Phase 1/2 Study of the Oral RET Inhibitor LOXO 292 in Pediatric Patients With Advanced RET-Altered Solid or Primary Central Nervous System Tumors (LIBRETTO-121)

This is an open-label, multi-center Phase 1/2 study of oral LOXO-292 in pediatric participants with an activating rearranged during transfection (RET) alteration and an advanced solid or primary CNS tumor.

measurable disease
RET
metastasis
cns tumor
renal function
  • 38 views
  • 20 Oct, 2022
  • 19 locations