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Found 70 clinical trials
Speeding the Weaning up: Aggressive Screening Criteria and Higher Minimal Ventilatory Settings.

: This is a multicenter randomized open trial with 4 arms. Screening with PaO2/FiO2 > 180 and PEEP 10cm H2O; SBT with "HIGH minimal ventilator settings" (PS 8 + PEEP 5 cm H2O).

  • 0 views
  • 03 May, 2021
  • 1 location
High Flow Nasal Cannula With Noninvasive Ventilation

This is a prospective, randomized, unblinded trial of trauma patients in the ICU who are identified as being at a high risk to develop acute respiratory failure. We hope that this study will help the study team to identify how best to use a more aggressive respiratory treatment strategy in …

  • 0 views
  • 26 Apr, 2022
  • 1 location
Phase IIb Trial of Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) (Ad5-nCoV) in Adults 18 Years of Age and Older.

A randomized, double-blind, placebo -controlled, phase IIb clinical trial to evaluate the efficacy, safety and immunogenicity of one or two doses of Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) in adults 18 years of age and older, living with HIV, on stable treatment, and virologically suppressed for at least …

  • 0 views
  • 01 Oct, 2021
  • 4 locations
The Relationship Between Oxygen Reserve Index and PaO2

partial pressure of arterial blood oxygen (PaO2) in children.

Accepts healthy volunteers
  • 2 views
  • 12 May, 2022
  • 1 location
Nurses-driven Capnography-guided Protocol Weaning From the Mechanical Ventilation at Bedside: A Feasibility Study

following criteria are present: PEEP 8 cmH2O, PaO2/FiO2 ratio 150 (mmHg) or SaO2 90% with FiO2 0.5. The final criterion for study entry is successful completion of a 30-min spontaneous breathing test

  • 0 views
  • 21 Aug, 2021
  • 1 location
Use of Extracorporeal CO2 Removal in Case of Moderate to Severe ARDS to Apply an Ultraprotective Mechanical Ventilation Strategy

The extracorporeal CO2 removal (ECCO2R) has been recently proposed in case of Acute Respiratory Distress Syndrome (ARDS) in order to reduce pulmonary injuries induced by the mechanical ventilation. A reducing of tidal volume and/or respiratory rate is thus expected using this extracorporeal respiratory support. However, most of existing devices of …

  • 0 views
  • 19 Mar, 2021
  • 1 location
Hyperpolarized MRI of Lung Transplants

Chronic complications such as chronic lung allograft dysfunction (CLAD) remain the leading cause of death and the primary limitation to long-term survival for lung transplant recipients. CT is currently use for longitudinal assessment in the pediatric population with lung transplant. However, it uses radiation that has been related to increase …

  • 0 views
  • 08 Jul, 2021
  • 1 location
Flow Rates of High-flow Nasal Cannula and Extubation Outcome

This is a single-center, open-label, randomized controlled trial to evaluate the effect of high-flow nasal cannula with a flow rate of 60 L/min versus 40 L/min after planned extubationon on a composite outcome of reintubation and use of NIV.

  • 0 views
  • 26 Sep, 2021
  • 1 location
Inverse Ratio Ventilation in Neonatal Open Repair of Tracheoesophageal Fistula.

Background and Objectives: Maintaining oxygenation during neonatal open repair of esophageal atresia is difficult. Inverse ratio ventilation can be used during one lung ventilation (OLV) to improve the oxygenation and lung mechanics. The investigators will compare inverse ratio to conventional ratio ventilation during OLV in neonatal open repair of esophageal …

  • 0 views
  • 16 Dec, 2021
  • 1 location
Improving Tissue Oxygenation in Breast Reconstruction Surgery

Breast reconstruction is an integral part of breast cancer care. There are two main types of breast reconstruction: alloplastic (using implants), and autologous (using patient's tissue). The latter creates a more natural breast mound, and avoids long-term concerns requiring surgical re-intervention associated with implant-based surgery. The deep inferior epigastric perforator …

  • 10 views
  • 21 Apr, 2022
  • 2 locations