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Found 17 clinical trials
A Multicenter Phase 2 Single-arm Proof-of-concept Trial to Assess the Efficacy and Safety of Ustekinumab in Association With Prednisone for the Treatment of Non-infectious Severe Uveitis (NISU)

posterior segment, either primarily in the vitreous (intermediate uveitis), the choroid or retina (posterior uveitis), or involving the entire eye (panuveitis). The term "uveitis" denotes a heterogeneous

  • 4 views
  • 16 Apr, 2021
  • 3 locations
Ocular Sarcoidosis Open Label Trial of ACTHAR Gel

Treatment with ACTHAR Gel will result in a reduction of ocular inflammation in patients with active ocular sarcoidosis that requires systemic immunosuppressant therapy (hypothesis)

immunosuppressant
acute anterior uveitis
anterior uveitis
corticosteroids
panuveitis
  • 0 views
  • 13 Feb, 2021
  • 1 location
Intravitreal Sirolimus as Therapeutic Approach to Uveitis

The purpose of this study is to find out about the safety and effectiveness of two different doses the study drug, sirolimus, administered intravitreally in patients with uveitis. The potential effectiveness of sirolimus can be utilized to control inflammation in uveitis and yet avoid the potential complications that are usually …

corticosteroids
prednisone
panuveitis
immunosuppressive agents
  • 162 views
  • 24 Jan, 2021
  • 1 location
Evaluation of EYS606 in Patients With Non-infectious Posterior Intermediate or Panuveitis

Primary objective: safety and tolerability Secondary objectives: additional indicators of long term safety and indicators of clinical activity Exploratory objectives: to characterize EYS606 biodistribution, immunogenicity and biomarkers

  • 122 views
  • 24 Jan, 2021
  • 7 locations
Quality of Life and Visual Function in Uveitis Patients

The purpose of this study was to measure the quality of visual function and quality of daily living in patients with anterior, posterior, and panuveitis.

panuveitis
  • 140 views
  • 07 Nov, 2020
  • 1 location
Gut Microbiota and Behcet's Syndrome: a Dietary Intervention Trial (MAMBA Study)

Behcet's syndrome (BS) is an idiopathic, chronic, multi-systemic inflammatory disorder characterized by ocular disease, skin lesions, vascular, neurological and gastrointestinal involvement. A recent study showed a peculiar dysbiosis of gut microbiota (GM) in BS patients, with specific changes in the profiles of short-chain fatty acids, especially butyrate. Over the last …

short-chain fatty acids
mediterranean diet
eye disease
inflammatory disorder
skin lesions
  • 4 views
  • 22 Jan, 2021
  • 1 location
Neuro-ultrasound Assessment in Behcet's Disease

Assessment of structural changes that occur in large extracranial and intracranial arteries in patients with Behcet's disease

  • 0 views
  • 14 Feb, 2021
  • 1 location
Golimumab for the Treatment of Refractory Behcet's Uveitis

The aim of this single-center prospective study is to evaluate the efficacy and safety of Golimumab GOL, fully humanized anti-tumor necrosis factor (TNF)- monoclonal antibody, in the treatment of refractory Uveitis of Behet's disease (BDU), to verify its effects on decreasing the dose of cortical steroids, and to determine whether …

monoclonal antibodies
immunosuppressant
behcet's syndrome
monoclonal antibody
corticosteroids
  • 1 views
  • 21 Mar, 2021
  • 1 location
Antiangiogenic Therapy of Choroidal Neovascularisation Associated With Central Chorioretinitis

The purpose of this study is to determine the effectiveness of antiangiogenic therapy to choroidal neovascularization secondary to central chorioretinitis.

  • 0 views
  • 16 Feb, 2021
  • 3 locations
Etanercept: Single Blind Control Study in Ocular Manifestations of Behcet's Disease

The purpose of this study is to find if Etanercept can improve the outcome of ocular lesions of Behcet's Disease treated with Methotrexate and Prednisolone

vasculitis
methotrexate
uveitis
  • 2 views
  • 07 Nov, 2020
  • 1 location