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Found 35 clinical trials
Irinotecan With or Without Panitumumab or Cyclosporine in Treating Patients With Advanced or Metastatic Colorectal Cancer That Did Not Respond to Fluorouracil

. Cyclosporine may help irinotecan work better by making tumor cells more sensitive to the drug. Monoclonal antibodies, such as panitumumab, can block tumor growth in different ways. Some block the

panitumumab
monoclonal antibodies
tumor growth
metastatic colorectal cancer
tumor cells
  • 129 views
  • 07 Nov, 2020
  • 12 locations
Comparison FOLFIRINOX Panitumumab vs mFOLFOX6 Panitumumab in RAS/B-RAF Wild-type Metastatic Colorectal Cancer Patients

National trial, multicenter, randomized, phase II assessing FOLFIRINOX + Panitumumab versus mFOLFOX6 + Panitumumab in metastatic colorectal cancer patients selected by RAS and B-RAF status from

measurable disease
folfirinox
oxaliplatin
metastasis
adenocarcinoma of colon
  • 15 views
  • 02 Aug, 2021
  • 9 locations
Imaging With [89Zr]Panitumumab-PET/MRI in Patients With Newly Diagnosed Colorectal Cancer

This clinical study will investigate the utility of PET imaging with [89Zr]Panitumumab for imaging of EGFR expression in newly diagnosed colon cancer patients to assess lymph node involvement

cancer
EGFR
  • 0 views
  • 25 Jan, 2021
  • 1 location
Re-challenge Therapy With Chemotherapy & Panitumumab in Metastatic Colorectal Cancer Patients Treated With an Anti-EGFR

RAS-wild upon retesting will receive rechallenge with panitumumab and chemotherapy

KRAS
measurable disease
oxaliplatin
bevacizumab
metastatic adenocarcinoma
  • 0 views
  • 26 Jan, 2021
  • 1 location
  • 0 views
  • 14 Feb, 2021
  • 6 locations
Early-Line Anti-EGFR Therapy to Facilitate Retreatment for Select Patients With mCRC

The study will use previously established doses of panitumumab or cetuximab in the metastatic setting for the treatment of unresectable colorectal cancer (CRC). It is designed to investigate an

  • 0 views
  • 27 Jun, 2021
  • 1 location
FOLFOX + Panitumumab According to a "Stop and go" Strategy With a Reintroduction Loop After Progression on Fluoropyrimidine as Maintenance Treatment as the First Line in Patients With Metastatic Colorectal Adenocarcinoma Without a RAS Mutation

Single-arm, multi-centre phase II study The primary objective is to evaluate the time to failure of the strategy.

colorectal adenocarcinoma
metastasis
ras mutation
metastatic colorectal adenocarcinoma
neutrophil count
  • 19 views
  • 05 Mar, 2021
  • 47 locations
Detection of the Emergence of RAS (Rat Sarcoma Viral Oncogene Homolog) Mutations in Circulating DNA (Deoxyribonucleic Acid) in Patients With mCRC (Metastatic Colorectal Cancer) During Treatment With Anti-EGFR (Epidermal Growth Factor Receptor) Therapy

The analysis of circulating DNA (Deoxyribonucleic acid) to identify potential resistance mechanisms during anti-EGFR (epidermal growth factor receptor) treatment is of great interest, as evidenced by the recent journal published by Corcoran in the prestigious New England Journal of Medicine. EmutRAS is one of the first studies that will specifically …

solid tumour
rat sarcoma
oxaliplatin
metastasis
primary tumor
  • 1 views
  • 15 Feb, 2021
  • 2 locations
LONsurf and G-CSF Use: Being On A Right Dose-intensity to Optimize Treatment Efficacy

Prospective cohort of patients treated with trifluridine/tipiracil, maximal sample size 250 patients. It is expected, that 89 patients will experience a grade 3-4 neutropenia and will be included in the phase II.

oxaliplatin
bevacizumab
liver metastasis
tipiracil
vegf
  • 0 views
  • 04 Feb, 2021
  • 19 locations
iSCORE: Immunotherapy Sequencing in COlon and REctal Cancer

This is a single-arm, single centre open-label, phase II interventional clinical trial of combination immunotherapy with Nivolumab and Relatlimab in mCRC.

measurable disease
adenocarcinoma
nivolumab
  • 11 views
  • 24 Jan, 2021
  • 1 location