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Found 15 clinical trials
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Eltrombopag Added to Standard Immunosuppression in Treatment-Naive Severe Aplastic Anemia

Background: Severe aplastic anemia is a rare and serious blood disorder. It happens when the immune system starts to attack the bone marrow cells. This causes the bone marrow to stop making red blood cells, platelets, and white blood cells. Standard treatment for this disease is horse-ATG and cyclosporine, which …

myelodysplastic syndrome (mds)
myelodysplastic syndromes
anemia
anemia studies
aplastic anemia
  • 123 views
  • 22 Dec, 2020
  • 1 location
Haploidentical Bone Marrow Transplant With Post-Transplant Cyclophosphamide for Patients With Severe Aplastic Anemia

Severe aplastic anemia is a rare and serious form of bone marrow failure related to an immune-mediated mechanism that results in severe pancytopenia and high risk for infections and bleeding

pancytopenia
hla-a
immunosuppression
fludarabine
cyclophosphamide
  • 20 views
  • 05 Mar, 2021
  • 2 locations
Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA)

Background Severe aplastic anemia (SAA) is a rare and serious blood disorder. It causes the immune system to turn against bone marrow cells. Standard treatment for SSA is a combination of 3 drugs (Cyclosporine [CsA], Eltrombopag [EPAG], and horse anti-thymocyte globulin [h-ATG]). Researchers want to see if starting people at …

neutrophil count
immunosuppressant
antithymocyte globulin
aplastic anemia
cyclosporine
  • 1 views
  • 21 Jun, 2021
  • 1 location
Study to Evaluate of EXG34217 in Patients With Telomere Biology Disorders With Bone Marrow Failure

This is a Phase I/II, open label, single center study to assess the safety and tolerability of EXG34217 in bone marrow failure patients with telomere biology disorders.

  • 0 views
  • 21 Apr, 2021
  • 1 location
Reduced Intensity BMT for Immune Dysregulatory and Bone Marrow Failure Syndromes Using Post-Transplant Cyclophosphamide

This is a Phase II prospective trial to assess the rates of donor engraftment using reduced intensity conditioning (RIC) hematopoietic stem cell transplant (HSCT) and post-transplant cyclophosphamide (PTCy) for patients with primary immune deficiencies (PID), immune dysregulatory syndromes (IDS), and inherited bone marrow failure syndromes (IBMFS).

immune globulin
lad-1
alemtuzumab
forced vital capacity
cyclophosphamide
  • 0 views
  • 24 Jan, 2021
  • 1 location
Eltrombopag With Standard Immunosuppression for Severe Aplastic Anemia

Background Severe aplastic anemia is a rare and serious blood disorder. It happens when the immune system starts to attack the bone marrow cells. This causes the bone marrow to stop making red blood cells, platelets, and white blood cells. Standard treatment for this disease is horse-ATG and cyclosporine, which …

neutrophil count
immunosuppressant
aplastic anemia
cyclosporine
horse anti-thymocyte globulin
  • 114 views
  • 18 Jul, 2021
  • 1 location
Cord Blood Transplant in Children and Young Adults With Blood Cancers and Non-malignant Disorders

This is a single-arm study to investigate 1-year treatment related mortality (TRM) in patients with life threatening non-malignant and malignant hematologic disorders who do not have a matched related donor for allogeneic transplantation.

fludarabine
minimal residual disease
cytopenia
cell transplantation
clofarabine
  • 0 views
  • 19 May, 2021
  • 1 location
Umbilical Cord Blood Transplant Cyclophosphamide Fludarabine and Total-Body Irradiation in Treating Patients With Hematologic Disease

This phase II trial studies how well giving an umbilical cord blood transplant together with cyclophosphamide, fludarabine, and total-body irradiation (TBI) works in treating patients with hematologic disease. Giving chemotherapy, such as cyclophosphamide and fludarabine, and TBI before a donor umbilical cord blood transplant helps stop the growth of cancer …

cancer
blast crisis
hematologic disorders
multiple myeloma
cyclophosphamide
  • 125 views
  • 11 Apr, 2021
  • 3 locations
Medical Home Care for Hematopoietic Stem Cell Transplantation Phase 2

-related mortality. This is due in large part to the prolonged pancytopenia and immunosuppression associated with the preparatory regimen of chemotherapy and/or radiation and the wait until engraftment of

cancer
cell transplantation
graft versus host disease
  • 6 views
  • 07 Jul, 2021
  • 1 location
Hemophagocytosis in Critically Ill Adult Patients

The purpose of the study is to find out whether non-responsiveness to therapeutic recombinant human granulocyte colony-stimulation factor (rhG-CSF) is associated with hemophagocytosis in critically ill adult patients with cytopenias.

  • 0 views
  • 24 Jan, 2021
  • 2 locations