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Found 997 clinical trials
A Study of Multiple Immunotherapy-Based Treatment Combinations in Participants With Metastatic Pancreatic Ductal Adenocarcinoma (Morpheus-Pancreatic Cancer)

A Phase Ib/II, open-label, multicenter, randomized study designed to assess the safety, tolerability, pharmacokinetics and preliminary anti-tumor activity of immunotherapy-based treatment combinations in participants with metastatic Pancreatic Ductal Adenocarcinoma (PDAC). Two cohorts will be enrolled in parallel in this study: Cohort 1 will consist of patients who have received no …

oxaliplatin
pancreatic ductal adenocarcinoma
combinations
leucovorin
bevacizumab
  • 322 views
  • 25 Jul, 2022
  • 15 locations
A Pivotal Study of Safety and Effectiveness of NanoKnife IRE for Stage 3 Pancreatic Cancer (DIRECT)

Subjects will be offered the opportunity to participate in a randomized, controlled, 2-arm, unblinded multicenter trial (RCT). There will be 2 study arms: the control arm receiving chemotherapy with the modified FOLFIRINOX regimen alone; and the irreversible electroporation (IRE) arm, receiving chemotherapy with the modified FOLFIRINOX regimen followed by IRE …

folfirinox
pancreatic adenocarcinoma
adenocarcinoma
  • 111 views
  • 05 May, 2022
  • 12 locations
Impact of Nationwide Enhanced Implementation of Best Practices in Pancreatic Cancer Care (PACAP-1) (PACAP-1)

PACAP-1 will evaluate to what extent an enhanced implementation of best practices in pancreatic cancer care leads to a prolonged survival and improvement of quality of life as compared to current practice.

  • 68 views
  • 04 Mar, 2022
  • 16 locations
Study of Efficacy and Safety of NIS793 in Combination With Standard of Care (SOC) Chemotherapy in First-line Metastatic Pancreatic Ductal Adenocarcinoma (mPDAC) - daNIS-2

The purpose of this study is to evaluate the efficacy and safety of NIS793 in combination with gemcitabine/nab-paclitaxel versus gemcitabine/nab-paclitaxel and placebo in first-line metastatic pancreatic ductal adenocarcinoma (mPDAC). This study aims to explore whether blockade of Transforming Growth Factor β (TGFβ) in combination with gemcitabine/nab-paclitaxel can reduce fibrosis in …

  • 0 views
  • 12 Jul, 2022
  • 36 locations
Study of Efficacy and Safety of NIS793 (With and Without Spartalizumab) in Combination With SOC Chemotherapy in First-line Metastatic Pancreatic Ductal Adenocarcinoma (mPDAC) (daNIS-1)

The purpose of this Phase II study is to assess the efficacy and safety of NIS793 with and without spartalizumab in combination with gemcitabine/nab-paclitaxel versus gemcitabine/nab-paclitaxel in untreated mPDAC.

  • 63 views
  • 01 May, 2022
  • 27 locations
Acute Pancreatitis Targets (APT) Study (APT)

The severity of acute pancreatitis varies considerably from minor symptoms to multi-organ failure. The pathophysiological mechanisms associated with these individual differences in severity are

Accepts healthy volunteers
  • 0 views
  • 10 Aug, 2022
  • 1 location
Balanced Crystalloid Solutions for Acute Pancreatitis

Patients diagnosed with acute pancreatitis regardless of etiology, severity of disease, and prior attacks will be randomized in two groups. The intervention group will receive a balanced

  • 0 views
  • 29 Jan, 2021
  • 1 location
Treating Acute Pancreatitis With Dabigatran, a Pilot Study

Researchers are studying the safety and efficacy of Dabigatran in the treatment of acute pancreatitis.

acute pancreatitis
amylase
  • 5 views
  • 21 Apr, 2022
  • 1 location
Effects of Peripherally Acting µ-opioid Receptor Antagonists on Acute Pancreatitis

This study will investigate the effect of peripheral acting opioid antagonist (PAMORA) on the disease course of patients with acute inflammation of the pancreas (acute pancreatitis). The study

  • 0 views
  • 13 Dec, 2021
  • 4 locations
Randomised Treatment of Acute Pancreatitis With Infliximab: Double-blind Multi-centre Trial (RAPID-I) (RAPID-I)

This study evaluates the effectiveness and safety of infliximab in the treatment of acute pancreatitis in adults. A third of participants will receive one single dose of infliximab via infusion

abdominal pain
acute pancreatitis
amylase
  • 7 views
  • 11 Mar, 2022
  • 1 location