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Found 5 clinical trials
Pancreatic Islet Transplantation Into the Anterior Chamber of the Eye

The treatment in this trial consists of intraocular islet transplantation. A single dose of 1000 - 2000 Islet Equivalents (IEQ)/kg recipient body weight (BW) will be infused into the anterior chamber of the eye through a self-sealing incision of the peripheral cornea. The procedure is projected to take approximately 20-30 …

diabetic retinopathy
self-monitoring
kidney transplant
continuous glucose monitoring
type 2 diabetes mellitus
  • 33 views
  • 08 Feb, 2022
  • 2 locations
Novel Method of Pancreatic Islet Transplantation Into the Omentum

The investigators propose to conduct a pilot clinical study in 10 type 1 diabetic subjects suffering from hypoglycemia unawareness syndrome and episodes of severe hypoglycemia, in which therapy with transplantation of allogeneic pancreatic islets would be indicated according to current criteria at the Institute for Clinical and Experimental Medicine (IKEM). …

  • 0 views
  • 05 Sep, 2021
  • 1 location
Pancreatic Islet Transplantation in the Anterior Chamber of the Human Eye - a Pilot Study

The overall objective is to establish that transplantation of allogeneic pancreatic islet cells into the anterior chamber of a severely visual impaired diabetic human eye is safe and does not cause ophthalmic or systemic complications. Furthermore, the change in insulin production, glucose control and hypoglycaemia awareness will be assessed.

kidney transplant
diabetes
hypoglycemia
insulin
immunosuppression
  • 15 views
  • 23 Feb, 2022
  • 1 location
Intra-Portal Alone Versus Intra- and Extra-Portal Transplantation of Pancreatic Islets After Total Pancreatectomy for Chronic Pancreatitis (iSite)

Randomized pilot trial of patients (n=30) undergoing Total Pancreatectomy and Islet AutoTransplant (TPIAT). Patients with islet harvest of greater than 5000 islet equivalents/kg body weight will be randomized to receive a portion of their islets into an omental pouch. For outcomes related to islet function, a group of normal volunteers …

pancreatectomy
Accepts healthy volunteers
  • 0 views
  • 15 Feb, 2022
  • 1 location
Treatment of Type I Diabetes by Islet Transplantation Into the Gastric Submucosa Study Protocol

The goal of this trial is to gain initial clinical experience regarding the safety and efficacy of treating type I diabetes in people who have received a kidney transplant by transplanting islets into a new transplant site in the stomach (gastrointestinal submucosa). A total of 6 patients will be enrolled …

diabetes
immunosuppression
tacrolimus
insulin
mycophenolate mofetil
  • 215 views
  • 23 Apr, 2022
  • 1 location