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Found 90 clinical trials
Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors

This study will evaluate palbociclib in combination with chemotherapy (temozolomide with irinotecan and topotecan with cyclophosphamide) in children, adolescents and young adults with recurrent

temozolomide
measurable disease
rhabdoid tumor
diffuse intrinsic pontine glioma
sarcoma
  • 113 views
  • 27 Jan, 2021
  • 60 locations
Radiation Therapy Palbociclib and Hormone Therapy in Treating Breast Cancer Patients With Bone Metastasis

This phase II trial studies how well radiation therapy given with standard care palbociclib and hormone therapy work in treating patients with breast cancer that has spread from one part of the

  • 18 views
  • 25 Jan, 2021
  • 10 locations
Locoregional Treatment and Palbociclib in de Novo Treatment Naive Stage IV ER+ HER2- Breast Cancer Patients

Approximately 3.5% to 6% of newly diagnosed breast cancer patients are stage IV metastatic. De novo metastatic breast cancer accounts for 20% to 25% of these cases. Despite a decrease in mortality in Europe and North America due to early detection and access to treatment, breast cancer remains the 2 …

bone metastases
adenocarcinoma
letrozole
estrogen
cancer
  • 0 views
  • 25 Jan, 2021
  • 34 locations
PAveMenT: Palbociclib and Avelumab in Metastatic AR+ Triple Negative Breast Cancer

This clinical study is aiming to determine the safest doses and schedule for the combination of two drugs named palbociclib and avelumab. The study will also be investigating how

measurable disease
stage iv breast cancer
hysterectomy
estrogen
cancer
  • 0 views
  • 25 Jan, 2021
  • 1 location
Stereotactic Radiosurgery With Abemaciclib Ribociclib or Palbociclib in Treating Patients With Hormone Receptor Positive Breast Cancer With Brain Metastases

This phase I trial studies the side effects of stereotactic radiosurgery with abemaciclib, ribociclib, or palbociclib in treating patients with hormone receptor positive breast cancer that has

  • 0 views
  • 26 Jan, 2021
  • 3 locations
Talazoparib and Palbociclib Axitinib or Crizotinib for the Treatment of Advanced or Metastatic Solid Tumors TalaCom Trial

This phase Ib trial is to find out the best dose, possible benefits and/or side effects of talazoparib when given in combination with palbociclib, axitinib, or crizotinib in treating patients

  • 0 views
  • 08 Mar, 2021
  • 1 location
Pembrolizumab Letrozole and Palbociclib in Treating Postmenopausal Patients With Newly Diagnosed Metastatic Stage IV Estrogen Receptor Positive Breast Cancer

This phase II trial studies how well pembrolizumab works when given together with letrozole and palbociclib in treating postmenopausal patients with newly diagnosed stage IV estrogen receptor

measurable disease
letrozole
hysterectomy
neutrophil count
international normalized ratio
  • 92 views
  • 19 Feb, 2021
  • 7 locations
A Study of ZW25 (Zanidatamab) With Palbociclib Plus Fulvestrant in Patients With HER2+/HR+ Advanced Breast Cancer

This is a multicenter, Phase 2a, open-label, 2-part study to investigate the safety, tolerability, and anti-tumor activity of ZW25 (zanidatamab) in combination with palbociclib plus fulvestrant

  • 0 views
  • 18 Feb, 2021
  • 12 locations
Binimetinib and Palbociclib or TAS-102 in Treating Patients With KRAS and NRAS Mutant Metastatic or Unresectable Colorectal Cancer

This phase II trial studies how well binimetinib and palbociclib work compared to TAS-102 in treating patients with KRAS and NRAS mutation positive colorectal cancer that has spread to other

  • 4 views
  • 02 Feb, 2021
  • 16 locations
Palbociclib Plus Letrozole Treatment After Progression to Second Line Chemotherapy for Women With ER/PR-positive Ovarian Cancer.

The primary objective of this study is to evaluate 12 weeks progression-free survival (PFS) rate of Palbociclib plus Letrozole in ER/PR positive endometrioid or high-grade serous ovarian cancer

cancer chemotherapy
neutrophil count
estrogen
cancer of the ovary
platinum-based chemotherapy
  • 5 views
  • 28 Jan, 2021
  • 9 locations