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Found 91 clinical trials
High Risk ER+HER2- T1-2N0-1 Early Breast Cancer With Palbociclib Plus Endocrine Therapy(HIPEx)

This is a phase II, multi-center, single-arm, open-label trial to evaluate efficacy of palbociclib with endocrine therapy as adjuvant treatment in women with C-high/G-high risk ER-positive/HER2

mammogram
breast-conserving surgery
invasive breast cancer
primary tumor
HER2
  • 0 views
  • 24 Jan, 2021
  • 1 location
Amcenestrant (SAR439859) Plus Palbociclib as First Line Therapy for Patients With ER (+) HER2(-) Advanced Breast Cancer

Primary Objective: To determine whether Amcenestrant (SAR439859) in combination with palbociclib improvesprogression free survival (PFS) when compared with letrozole in combination with

HER2
palbociclib
letrozole
measurable disease
advanced breast cancer
  • 0 views
  • 03 Mar, 2021
  • 70 locations
Phase 1 / 2 Study of SAR439859 Single Agent and in Combination With Other Anti-cancer Therapies in Postmenopausal Women With Estrogen Receptor Positive Advanced Breast Cancer

Primary Objectives: Dose Escalation: Part A (SAR439859 monotherapy); Part C (combination of SAR439859 with palbociclib); Part F (Safety-Run-In - combination of SAR439859 with alpelisib

primary tumor
HER2
palbociclib
breast adenocarcinoma
aromatase inhibitor
  • 904 views
  • 17 Feb, 2021
  • 42 locations
Impact of eHealth-support on Quality of Life in Metastatic Breast Cancer Patients Treated With Palbociclib and Endocrine Therapy

cancer treated with the cyclin dependent kinase 4/6 (CDK4/6) Inhibitor Palbociclib in combination with an aromatase inhibitor or fulvestrant. Furthermore this approach will be combined with biomarker

cancer
immunohistochemistry
HER2
palbociclib
aromatase inhibitor
  • 45 views
  • 27 Jan, 2021
  • 1 location
A Study of ZN-c5 in Subjects With Breast Cancer

palbociclib (IBRANCE).

EGFR
growth factor
HER2
palbociclib
breast adenocarcinoma
  • 47 views
  • 03 Mar, 2021
  • 51 locations
To Reduce the Use of Chemotherapy in Postmenopausal Patients With ER-positive and HER2-positive Breast Cancer (TOUCH)

neoadjuvant palbociclib in combination with hormonal therapy and HER2 blockade, versus the treatment with paclitaxel in combination with HER2 blockade.

mammogram
tamoxifen
core needle biopsy
letrozole
estradiol
  • 17 views
  • 30 Jan, 2021
  • 63 locations
Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors Non-Hodgkin Lymphomas or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

This Pediatric MATCH screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists …

donor lymphocyte infusion
solid tumor
tipifarnib
nitrosoureas
131i-mibg
  • 990 views
  • 03 Mar, 2021
  • 113 locations
Palbociclib + Ganitumab In Ewing Sarcoma

This research study is designed to study the combination of two drugs, palbociclib and ganitumab, as a potential treatment for Ewing sarcoma. The names of the study drugs involved in this

stem cell infusion
biological therapy
growth factor
myelosuppressive chemotherapy
monoclonal antibodies
  • 12 views
  • 24 Jan, 2021
Palbociclib In Progressive Brain Metastases

This research study is studying palbociclib as a possible treatment for recurrent brain metastases. Pfizer, a pharmaceutical company, is supporting this research study by providing

  • 84 views
  • 25 Jan, 2021
  • 2 locations
Palbociclib With Fulvestrant for Metastatic Breast Cancer After Treatment With Palbociclib and an Aromatase Inhibitor

This study is being done to look at the role of continuing palbociclib treatment in combination with another type of hormonal therapy (fulvestrant) after disease progression of palbociclib in

palbociclib
kidney function tests
aromatase inhibitor
endocrine therapy
measurable disease
  • 0 views
  • 30 Jan, 2021
  • 5 locations