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Found 39 clinical trials
Precision-Based Genomics in Prostate Cancer

Background Prostate cancer is the most common cancer and the second leading cause of death in males in the United States. Researchers want to find additional gene mutations that may increase a man s risk for prostate cancer and may affect how aggressive the disease is. Objective To look at …

  • 0 views
  • 17 Jun, 2022
  • 1 location
LobularCard Trial: Searching for Novel Germline Mutations in Lobular Breast Cancer Patients (LobularCard)

This is a cross-sectional and retrospective study of a cohort of patients with invasive lobular breast cancer (LBC) or in situ lobular neoplasia (LIN3). The main endpoint is the relative frequency of patients with a germline mutation using a recent panel including 113 genes from the "Illumina" protocol. In case …

  • 0 views
  • 15 Jun, 2022
  • 1 location
Prospective Study of MAstectomy With Reconstruction Including Robot Endoscopic Surgery

Robotic mastectomy and immediate reconstruction have been introduced recently in 2015. However, since robotic mastectomy is latest surgical technique, there is a lack of studies comparing conventional mastectomy and immediate reconstruction with robotic mastectomy prospectively. For this reason, this study is designed to establish a single institution cohort study that …

palb2
BRCA1
TP53
mastectomy
BRCA1/2
  • 0 views
  • 20 Jun, 2021
  • 1 location
Pancreas Registry and High Risk Registry

The purpose of this study is to establish a registry of patients with pancreatic diseases. Patients included in the registry may include those with: pancreatic cancer, precancerous lesions of the pancreas, inflammatory lesions of the pancreas, cystic lesions of the pancreas, and patients at high-risk of pancreatic cancer such as …

palb2
cyst
disease or disorder
ATM
hereditary pancreatitis
  • 133 views
  • 08 Jun, 2022
  • 1 location
The PROFILE Study: Germline Genetic Profiling: Correlation With Targeted Prostate Cancer Screening and Treatment (PROFILE)

Prostate cancer is now the commonest cancer in men in the Western world, with over 49,000 new cases diagnosed each year and a lifetime risk of 1 in 11 in the United Kingdom. Prostate cancer (PrCa) can run in some families and research studies have identified several genetic changes in …

prostate cancer screening
prostate specific antigen
Accepts healthy volunteers
  • 1 views
  • 25 Apr, 2022
  • 1 location
Study of Quality of Life Post Salpingo-oophorectomy in BRCA1/2 & PALB2 Mutation Carriers (BRCA-HRT) (BRCA-HRT)

Premenopausal BRCA1 / 2 or PALB2 gene mutation carriers who receive hormone replacement therapy (HRT) after preventive salpingo-oophorectomy (PBSO) have a better quality of sexual

  • 0 views
  • 13 Jun, 2022
  • 1 location
Pilot Study of Pancreatic Cancer Screening

gene (ATM), or PALB2 screened for pancreatic cancer. This study may lead to a greater understanding of cancer and potentially, improvements in cancer screening and treatment.

palb2
endoscopic ultrasound
ATM
Accepts healthy volunteers
  • 0 views
  • 29 Apr, 2022
  • 1 location
Preliminary Evaluation of Screening for Pancreatic Cancer in Patients With Inherited Genetic Risk

high risk for pancreatic cancer, specifically those with BRCA1/2, ATM, or PALB2 mutations.

palb2
ATM
BRCA1
endoscopic ultrasound
BRCA1/2
  • 10 views
  • 15 Jun, 2022
  • 1 location
Men at High Genetic Risk for Prostate Cancer

Background Research studies have shown that genetic changes and family history may increase a man s risk for prostate cancer. Researchers want to follow the prostate health of men who have specific genetic changes associated with prostate cancer to help them learn more about which men are at higher risk …

MRI
testosterone
cancer
blood test
  • 109 views
  • 17 Jun, 2022
  • 1 location