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Found 38 clinical trials
Berzosertib and Irinotecan in Treating Patients With Progressive, Metastatic, or Unresectable TP53 Mutant Gastric or Gastroesophageal Junction Cancer

This phase II trial studies the how well berzosertib and irinotecan work in treating patients with gastric or gastroesophageal junction cancer that is growing, spreading or getting worse (progressive), has spread to other places in the body (metastatic), or cannot be removed by surgery (unresectable). Berzosertib may stop the growth …

  • 0 views
  • 16 Jun, 2022
  • 14 locations
Study Evaluating the Efficacy of a Double Immunotherapy Combined With Olaparib in Patients With Solid Cancers and Carriers of Homologous Recombination Repair Genes After Olaparib Treatment

The study propose to generate a clinical trial based on precision medicine to evaluate the use of immunotherapy in patients with altered homologous recombination repair genes and without progression after prior targeted therapy.

  • 0 views
  • 31 May, 2021
  • 8 locations
Niraparib Plus Carboplatin in Patients With Homologous Recombination Deficient Advanced Solid Tumor Malignancies

This is a multi-institutional Phase I dose-escalation and dose-expansion trial for patients with advanced, solid tumor malignancies who have pre-identified deleterious germline or somatic mutations in the homologous recombination deoxyribonucleic acid (DNA) repair pathway (HR deficient). The trial is designed to assess the efficacy and safety of niraparib plus carboplatin …

serum pregnancy test
solid tumor
neutrophil count
measurable disease
advanced solid tumor
  • 7 views
  • 09 Sep, 2021
  • 3 locations
A Registry for BRCA Mutation Carriers With Pancreatic Ductal Adenocarcinoma

PALB2. The investigators hope to do this by establishing a BRCA/PALB2 mutation carriers Pancreatic Ductal Adenocarcinoma (the common form of pancreatic cancer) Registry. A registry is a database of

pdac
cancer
Accepts healthy volunteers
palb2
  • 14 views
  • 24 Mar, 2022
  • 9 locations
Strategic Targeting for Optimal Prevention of Cancer (STOP-Cancer)

The primary goal of the study is to record data over the observation period to evaluate the clinical benefit of using hereditary cancer genomic diagnostics to assess overall hereditary genetic cancer risk profile and to help guide physicians to pursue preventative measures, which may lead to early detection and treatment …

  • 14 views
  • 09 Feb, 2022
  • 1 location
ScreenIng of Genetic Susceptibility Genes for Breast Cancer Patients in CHinese communiTies (SIGHT)

who voluntarily participate to carry out the detection of BRCA1, BRCA2, PTEN, CHEK2 and PALB2 genes through the community health service center.

BRCA2
BRCA1
CHEK2
palb2
PTEN
  • 0 views
  • 11 May, 2022
  • 1 location
Pancreatic Cancer Registry: For Any Person With a Personal or Family History

clustering in subsets of families. For example, in 2009 and 2012 the investigators discovered that mutations in the PALB2 and ATM genes jointly account up to 5% of the clustering of pancreatic cancer in

ATM
palb2
Accepts healthy volunteers
pancreatic neoplasm
  • 29 views
  • 09 Dec, 2021
  • 1 location
Homologous Recombination Deficiency Status in Epithelial Ovarian Cancer

, CDK12, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCI, FANCL, MRE11A, NBN, PALB2, PPP2R2A, PTEN, RAD50, RAD51B, RAD51C, RAD51D, RAD54B, RAD54, MLH1, MSH2, MSH6, PMS2, EPCAM, STK11

BAP1
RAD54B
MLH1
ATR
EPCAM
  • 0 views
  • 21 Feb, 2022
  • 1 location
Registry of Subjects at Risk of Pancreatic Cancer

IRFARPC is a multicenter national registry designed to study the diagnosis and predisposing factors of subjects with an inherited increased risk for pancreatic cancer.

  • 0 views
  • 23 Jan, 2021
  • 3 locations
Precision-Based Genomics in Prostate Cancer

Background Prostate cancer is the most common cancer and the second leading cause of death in males in the United States. Researchers want to find additional gene mutations that may increase a man s risk for prostate cancer and may affect how aggressive the disease is. Objective To look at …

  • 0 views
  • 17 Jun, 2022
  • 1 location