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Found 13 clinical trials
The Effects of Tranexamic Acid or Placebo on Perioperative Bleeding in Adults Undergoing Liver Transplantation.

Around 230 million major procedures are performed worldwide each year. Postoperative complications after major surgery, especially in solid organ transplants, are associated with a significant increase in costs and mortality. Major bleeding episodes in major surgeries such as liver transplantation are related to a significant impact on morbidity and mortality. …

venous thromboembolism
surgical blood loss
tranexamic acid
clot
stroke
  • 0 views
  • 02 Sep, 2021
  • 1 location
Role of Blood Management in Perioperative Outcomes

There is currently limited information regarding the role of blood management in the benign gynecologic population and specifically, in patients who are scheduled to undergo surgery for fibroids and/or abnormal uterine bleeding. A thorough search through PubMed and clinicaltrials.gov did not reveal any studies on this issue. In 2019 at …

  • 0 views
  • 28 Jul, 2022
  • 1 location
The HeLiX (Hemorrhage During Liver Resection: traneXamic Acid) Trial (HeLiX)

This is a Phase III multicentre randomized controlled trial (RCT) to evaluate the impact of tranexamic acid (TXA) on perioperative blood transfusion in patients undergoing liver resection. The rationale for this study includes: (1) experimental evidence supporting the use of TXA in other surgical populations; (2) lack of evidence in …

blood transfusion
primary cancer
cancer
liver surgery
  • 17 views
  • 23 Mar, 2022
  • 10 locations
Evaluation and Treatment of Iron Deficiency in Ovarian Cancer Patients

transfusion of packed red blood cells in the peri-operative period. 21 participants at least 18 years of age with epithelial ovarian cancer of any stage requiring neoadjuvant chemotherapy and surgery will be

blood transfusion
malnutrition
iron stores
venofer
transferrin saturation
  • 101 views
  • 09 Feb, 2022
  • 1 location
Treatment of Anemia With Intravenous Iron in Patients Listed for Orthotopic Liver Transplantation

) increases hemoglobin concentrations and reduces intraoperative transfusion of packed red blood cells (PRBCs). The investigators hypothesize that therapy with intravenous iron will increase hemoglobin

blood transfusion
orthotopic liver transplant
packed red blood cells
  • 0 views
  • 25 Jan, 2021
  • 1 location
Aortic Valve Sparing Root Replacement Versus Bentall

> primary outcome measures: Intraoperative or intrahospital death. Reexploration for bleeding. Units of packed red blood cells.

Accepts healthy volunteers
  • 0 views
  • 25 Mar, 2022
  • 1 location
Acute Normovolemic Hemodilution in Complex Cardiac Surgery (ANH)

Postoperative bleeding in cardiac surgery is a frequent complication, and cardiac surgery utilizes 15-20% of the national blood supply. Packed red blood cells (pRBCs) are associated with worse

hemodilution
bypass graft
postoperative bleeding
  • 0 views
  • 14 Mar, 2022
  • 1 location
Single-dose Intravenous Iron Therapy for Anemia After Orthopaedic Trauma

is transfusion of packed red blood cells in only cases of severe anemia due to the substantial associated risks. A safer alternative is desirable because a critical number of participants do not meet

  • 0 views
  • 28 May, 2022
  • 1 location
Transfusion of Biotinylated Red Blood Cells (b-RBCs)

The purpose of this research is to study how red blood cells (RBCs) survive in a person's circulation, and how that survival may be different in red blood cells that are donated and stored prior to being transfused. Investigators will study this by collecting blood samples from participants, "labeling" RBCs …

blood transfusion
vitamins
Accepts healthy volunteers
  • 41 views
  • 24 Mar, 2022
  • 1 location
The Effect of Tranexamic Acid on Blood Coagulation in Total Hip Arthroplasty Surgery

Total hip arthroplasty (THA) is associated with blood loss ranging from 300 to 2000 mL. Tranexamic acid (TXA) is frequently administered prophylactically during this procedure to reduce blood loss by inhibiting fibrinolysis or by stopping naturally occurring clot resolution. TXA is employed currently based on a surgeon's preference. The objective …

hip arthroplasty
anesthesia
tranexamic acid
clot
joint arthroplasty
  • 0 views
  • 13 May, 2022
  • 1 location