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Found 11 clinical trials
PK Study to Assess Drug-drug Interaction Between Sitravatinib and a Cocktail of Substrates

Study 516-010 is an open-label Phase 1, drug-drug interaction study evaluating the effect of sitravatinib on probe substrates for CYP450 enzymes and BCRP and P-gp transporters.

  • 0 views
  • 21 May, 2021
  • 1 location
Phenotyping of High Dose Rifampicin

assess the drug interaction potential of high dose rifampicin (~40 mg/kg daily dose, the currently available maximum tolerated dose) with respect to five major human drug-metabolizing CYP enzymes and P

  • 0 views
  • 23 Jul, 2021
  • 2 locations
The Possible Efficacy and Safety of Lansoprazole Co-administration With Neoadjuvant Chemotherapy in Women With Breast Cancer

Investigation of the possible efficacy and safety of lansoprazole co-administration with neoadjuvant chemotherapy in tumor response in women with breast cancer who will be planned for surgery.

mammogram
  • 0 views
  • 07 Jul, 2021
  • 1 location
Combination Chemotherapy Including Cisplatin Ifosfamide Gemcitabine L-asparaginase Etoposide and Dexamethasone as Treatment of Newly Diagnosed and Relapsed/Refractory Peripheral T Cell Lymphomas

The PIGLETS regimen was devised to replace the conventional SMILE regimen in management of extranodal NK/T cell lymphoma in our institution. It had been three years since the introduction of PIGLETS regimen in treatment of NK malignancies. The response rate is encouraging, with an overall response rate (ORR) of 90% …

cancer
etoposide
dexamethasone
t-cell lymphoma
  • 2 views
  • 22 Jan, 2021
Impact of Steady State Cobicistat and Darunavir/Cobicistat on the Pharmacokinetics and Pharmacodynamic of Oral Anticoagulants (Rivaroxaban Apixaban) in Health Volunteers

Background Rivaroxaban and apixaban are blood thinners. People with HIV may need to take them to treat or prevent blood clots. The anti-HIV drug darunavir (DRV) can increase the amount of these blood thinners in the body. This can cause bleeding or other health problems. The drug cobicistat (COBI) is …

blood test
fasting
body mass index
  • 6 views
  • 27 Apr, 2021
  • 1 location
DM-CHOC-PEN Plus Radiation for Brain Tumors

4-Demethyl-4-cholesteryloxycarbonylpenclomedine (DM-CHOC-PEN) is a polychlorinated pyridyl cholesterol carbonate that is lipophilic, electrically neural, crosses the blood brain barrier (BBB), ability to localize in intracranial tumor tissue, lacks neurotoxicity and not transported out of the brain via Pgp (p-glycoprotein) (1). DM-CHOC-PEN has completed Phase I/II trials in humans with primary and …

metastasis
nitrosoureas
p-glycoprotein
dm-choc-pen
estrogen
  • 13 views
  • 26 Jan, 2021
  • 3 locations
Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study)

Background Artificial sweeteners like sucralose are found in many foods and drinks. Sucralose might affect hormones and cause health changes. Objective To see if sucralose changes how medicines are absorbed and processed, how hormones are secreted, gut bacteria, and how fat cells are metabolized. Eligibility People ages 18-60 who: Are …

body mass index
midazolam
  • 708 views
  • 10 Jul, 2021
  • 1 location
DM-CHOC-PEN for Brain Tumors in AYA Subjects

4-Demethyl-4-cholesteryloxycarbonylpenclomedine (DM-CHOC-PEN) is a polychlorinated pyridyl cholesterol carbonate that is lipophilic, electrically neural, crosses the blood brain barrier (BBB), ability to localize in intracranial tumor tissue, lacks neurotoxicity and not transported out of the brain via Pgp (p-glycoprotein). DM-CHOC-PEN has completed a Phase I Adolescent and Young Adult (AYA) trial …

metastasis
nitrosoureas
cancer
p-glycoprotein
dm-choc-pen
  • 0 views
  • 24 Jan, 2021
  • 1 location
Implementing Standards of Care for Heart Failure Patients in General Practice - A Regional Disease Management Program

Heart failure (HF) is an important health problem. Most chronic HF management occurs in primary care. Although guidelines exist, there is an important implementation gap in current HF care in Belgium. We will conduct a non-randomized, non-controlled prospective observational trial to implement guideline-recommended best clinical practices in primary care in …

heart failure
natriuretic peptide
  • 1 views
  • 24 Jan, 2021
Intravenous Imatinib in Mechanically Ventilated COVID-19 Patients

The SARS-CoV2 pandemic and resulting COVID-19 infection has led to a large increase in the number of patients with acute respiratory distress syndrome (ARDS). ARDS is a severe, life-threatening medical condition characterised by inflammation and fluid in the lungs. There is no proven therapy to reduce fluid leak, also known …

  • 0 views
  • 02 Apr, 2021
  • 2 locations