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Found 330 clinical trials
The Randomised Study of Preoperative Radiotherapy With Consolidating Chemotherapy for Unresectable Rectal Cancer

The addition of Oxaliplatin to conventionally fractionated chemoradiation (FULV or capecitabine) is considered as standard in unresectable rectal cancer by the panel of experts. The

chemoradiotherapy
oxaliplatin
capecitabine
metastasis
  • 1 views
  • 07 Nov, 2020
  • 1 location
A Study to Assess the Effectiveness and Safety of Irinotecan Liposome Injection 5-fluorouracil/Leucovorin Plus Oxaliplatin in Patients Not Previously Treated for Metastatic Pancreatic Cancer Compared to Nab-paclitaxel+Gemcitabine Treatment

/leucovorin (5FU/LV) plus oxaliplatin compared to nab-paclitaxel + gemcitabine treatment in improving the overall survival of patients not previously treated for metastatic pancreatic cancer.

  • 31 views
  • 12 Jun, 2021
  • 272 locations
Trial of Preoperative Hepatic and Regional Arterial Chemotherapy (PHRAC) to Prevent Postoperative Liver Metastasis of Colorectal Cancer

The purpose of this study is to investigate whether preoperative hepatic and regional arterial chemotherapy are able to prevent liver metastasis and improve overall survival in patients receiving curative colorectal cancer resection.

oxaliplatin
adenocarcinoma
adenocarcinoma of colon
liver metastasis
metastasis
  • 5 views
  • 07 Nov, 2020
  • 1 location
Donafenib for Previously Treated Metastatic Colorectal Cancer

The investigators do the clinical trial (patients with metastatic colorectal cancer treated with donafenib/placebo after failure of standard therapy) to assess efficacy and safety of donafenib in patients with metastatic colorectal cancer, progressing after all approved standard therapies.

oxaliplatin
adenocarcinoma
irinotecan
carcinoma
adjuvant therapy
  • 0 views
  • 03 Jun, 2021
  • 2 locations
Circulating Tumour DNA Based Decision for Adjuvant Treatment in Colon Cancer Stage II Evaluation

The CIRCULATE study evaluates the adjuvant therapy in patients with colon cancer UICC stage II. The primary aim of the study is to compare the disease free survival in patients who are positive for postoperative circulating tumour DNA with vs. without capecitabine.

  • 0 views
  • 24 Jan, 2021
Neoadjuvant Treatment of HER2 Positive Early High-risk and Locally Advanced Breast Cancer

n the present study the neoadjuvant approach with the anti-HER2 trastuzumab and pertuzumab combined with carboplatin and paclitaxel will be used to compare the Event-Free Survival (EFS) in regimens with and without atezolizumab. Following the neoadjuvant part of the study, after surgery all patients will continue to receive trastuzumab and …

sentinel node
tubal ligation
paclitaxel
HER2
trastuzumab
  • 17 views
  • 24 Jan, 2021
  • 51 locations
Combination of Capecitabine and Oxaliplatin in Metastatic Nasopharyngeal Carcinoma

Primary: - To evaluate the efficacy of capecitabine in combination with oxaliplatin (XELOX) in terms of overall response rate (based on RECIST criteria) in patients with

metastatic nasopharyngeal carcinoma
carcinoma
karnofsky performance status
measurable disease
capecitabine
  • 15 views
  • 07 Nov, 2020
  • 1 location
LEAn Body Mass Normalization of OXaliplatin Based Chemotherapy

Cytotoxic chemotherapy is usually scaled to the body surface area (BSA), and is currently not adjusted to the body proportions of lean and fat (i.e. body composition) of individual patients. Patients with low muscle mass behave like patients "overdosed" with chemotherapy resulted in dose-limiting toxicities (e.g. dose reductions, treatment delays …

  • 3 views
  • 24 Jan, 2021
  • 1 location
Weekly Docetaxel Plus Cisplatin or Oxaliplatin for AGC

To evaluate the efficacy and safety of weekly administered combination of docetaxel/cisplatin and docetaxel/oxaliplatin in chemotherapy-naïve patients with advanced gastric cancer. The

oxaliplatin
cancer
docetaxel
gastric cancer
  • 6 views
  • 07 Nov, 2020
  • 1 location
Docetaxel Plus Oxaliplatin as Therapy in Patients With Pancreatic Cancer

The purpose of this study is to test a combination-therapy of oxaliplatin and docetaxel in patients with metastatic or locally advanced adenocarcinoma of the pancreas after failure of a

oxaliplatin
adenocarcinoma
drainage
pancreatic adenocarcinoma
docetaxel
  • 23 views
  • 07 Nov, 2020
  • 4 locations