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Found 21 clinical trials
A Study of PRT1419 Injection in Patients With Relapsed/Refractory Hematologic Malignancies

This is a Phase 1 dose-escalation study of PRT1419, a myeloid cell leukemia 1 (MCL1) inhibitor, in patients with relapsed/refractory hematologic malignancies. The purpose of this study is to define the dosing schedule, maximally tolerated dose and/or estimate the optimal biological dose to be used in subsequent development of PRT1419.

leukemia
hydroxyurea
leukapheresis
ejection fraction
cancer
  • 0 views
  • 23 Jul, 2022
  • 7 locations
Prospective Interventional Study Exploring the Microbiota Recolonization in SR-GvHD Patients Receiving MaaT013 (ORION) (ORION)

The objective of the ORION study is to explore the changes of gut microbiota composition following MaaT013 administration and its impact on the immune system in GVHD patients.

  • 0 views
  • 10 Jul, 2022
  • 3 locations
Umbilical Cord Mesenchymal Stem Cells in the Treatment of Moderate/Severe Chronic Graft-versus-host Disease

cGVHD is a systemic disease with multi-system damage similar to autoimmune and other immune diseases. It can affect multiple organs such as skin, liver, kidney, and peripheral nerves, causing a serious decline in the quality of life of patients, and death in the late stage of transplantation. According to the …

  • 0 views
  • 15 Dec, 2021
  • 1 location
Phase II Study of a Geriatric Assessment-Driven, Risk-Adapted Allogeneic Hematopoietic Cell Transplant Strategy for Older Patients With Myeloid Malignancies

This study will evaluate whether a geriatric assessment can lead to better treatment outcomes in older patients (age 60+) with a myeloid malignancy including acute myeloid leukemia, ,myelodysplastic syndromes, myeloproliferative neoplasms, or related blood disorders who are going to receive chemotherapy or another treatment to prepare the body for an …

myeloid leukemia
chronic myelomonocytic leukemia
leukemia
transplant conditioning
chronic myeloid leukemia
  • 0 views
  • 15 Sep, 2022
  • 7 locations
Decidua Stroma Cells for Steroid Resistent Acute Graft-versus-host Disease After Allo-HSCT

A two-stage design. An open, non-randomized, 3+3 dose escalating scheme will be used in the first stage of the study. A randomized (1:1) phase II open label study of DSC compared to Investigator choice Best Available Therapy (BAT) in allogeneic hematopoietic stem cell transplant recipients with Grades II-IV steroid refractory …

  • 0 views
  • 10 Oct, 2021
  • 6 locations
Seoul National University Airway Registry

This is a multicenter, prospective observational cohort study, in which patients with chronic airway diseases including chronic obstructive pulmonary disease(COPD), asthma, asthma-COPD overlap

asthma
COPD
airways disease
obstructive lung disease
respiratory symptom
  • 28 views
  • 21 Jan, 2021
  • 3 locations
Canadian Network for Autoimmune Liver Disease (CaNAL)

CaNAL is a longitudinal observational cohort study of patients diagnosed with Primary Biliary Cholangitis (PBC), Autoimmune Hepatitis (AIH), or overlap syndrome. This study creates a nationwide

liver failure
hepatitis
overlap syndrome
liver cancer
cholangitis
  • 70 views
  • 04 Mar, 2022
  • 7 locations
The Characteristic of Airway Microbiome Profiling of COPD-bronchiectasis Overlap Patients and Its Association With Acute Exacerbation

and structural criteria for the diagnosis of bronchiectasis create the possibility for individual patients to fulfil both, resulting conceptually in either co-diagnosis or an overlap syndrome between

  • 0 views
  • 14 May, 2021
  • 1 location
Cardio-pulmonary Rehabilitation and Sleep Quality

In this prospective cohort study the investigators aim to evaluate the effect of pulmonary rehabilitation on sleep quality. Disturbed sleep is associated with, frequent exacerbations, increase in the severity of disease and increased mortality in chronic obstructive pulmonary disease (COPD). Sleep quality is a good predictor of quality of life …

pulmonary rehabilitation
heart failure
COPD
rehabilitation program
  • 0 views
  • 19 Apr, 2022
  • 1 location
Biomarker Verification in Pediatric Chronic GvHD: ABLE 2.0 / PTCTC GVH 1901 Study

This study will validate a previously developed pediatric prognostic biomarker algorithm aimed at improving prediction of risk for the later development of chronic graft-versus-host disease (cGvHD) in children and young adults undergoing allogeneic hematopoietic stem cell transplant. By developing an early risk stratification of patients into low-, intermediate-, and high-risk …

bone marrow procedure
antithymocyte globulin
transplant conditioning
cyclophosphamide
alemtuzumab
  • 0 views
  • 14 Jul, 2022
  • 9 locations