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Found 13 clinical trials
Intratympanic N-Acetylcysteine for Prevention of Cisplatin-induced Ototoxicity.

Although many intratympanic agents have been attempted, N-Acetylcysteine (NAC) appears to be the most promising and is a powerful, commonly used anti-oxidant. The goal of this prospective phase 2 randomized controlled trial is to determine the optimal dosage and effectiveness of intratympanic NAC injection in reducing hearing loss in head …

  • 3 views
  • 28 Feb, 2022
  • 1 location
Low-Dose Weekly vs High-Dose Cisplatin (RADIO)

This study is a prospective open-label randomized clinical trial. Following informed consent eligible LASCCHN patients (n=100) planned for CRT will be stratified by tumor p16 status and then randomized in a 1:1 fashion to either concurrent HD cisplatin or concurrent weekly LD cisplatin.

  • 2 views
  • 15 Jun, 2022
  • 3 locations
Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma

The primary objective of this protocol is to evaluate the response rate of bilateral disease participants who have at least one eye with advanced intra-ocular retinoblastoma (stratum B) using upfront therapy with chemotherapy delivered directly to the eye. The main biology objective is to improve our understanding of the biology …

neutrophil count
carboplatin
unilateral retinoblastoma
etoposide
intraocular retinoblastoma
  • 43 views
  • 28 Jun, 2022
  • 1 location
Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors

This phase III trial studies how well active surveillance, bleomycin, etoposide, carboplatin or cisplatin work in treating pediatric and adult patients with germ cell tumors. Active surveillance may help doctors to monitor subjects with low risk germ cell tumors after their tumor is removed. Drugs used in chemotherapy, such as …

carboplatin
etoposide
tumor markers
beta human chorionic gonadotropin
seminoma
  • 629 views
  • 29 Jul, 2022
  • 344 locations
Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery

This partially randomized phase II/III trial studies how well, in combination with surgery, cisplatin and combination chemotherapy works in treating children and young adults with hepatoblastoma or hepatocellular carcinoma. Drugs used in chemotherapy, such as cisplatin, doxorubicin, fluorouracil, vincristine sulfate, carboplatin, etoposide, irinotecan, sorafenib, gemcitabine and oxaliplatin, work in different …

carboplatin
tumor cells
carcinoma
etoposide
glomerular filtration rate
  • 191 views
  • 26 Jul, 2022
  • 133 locations
Intratympanic Administration of N-acetylcysteine for Protection of Cisplatin-induced Ototoxicity

% against Cisplatin-induced ototoxicity. In this case, we will evaluate its effect through the transtympanic administration in both ears.

  • 0 views
  • 19 Feb, 2021
  • 1 location
Treatment of Radiation and Cisplatin Induced Toxicities With Tempol

week trial, mucositis, nephrotoxicity, and ototoxicity will be monitored and assessed.

neutrophil count
squamous cell carcinoma of the head and neck
head and neck cancer
tempol
a 10
  • 16 views
  • 25 Mar, 2022
  • 8 locations
Multichannel Vestibular Implant Early Feasibility Study

evaluate this approach in up to ten human subjects with bilateral vestibular deficiency due to gentamicin ototoxicity or other causes of inner ear dysfunction.

imbalance
gentamicin
nystagmus
bilateral vestibulopathy
  • 8 views
  • 27 Jan, 2022
  • 1 location
Verification of the Efficacy/Safety of the Intratympanic Drug Delivery for Hearing Loss

This study is a prospective, randomized pilot study. To verify an efficacy and safety of the Intratympanic drug delivery vehicle, patients who have not responded to the existing standard treatment will be enrolled. Hearing test, endoscopy of tympanic membrane and CT scans will be conducted after intratympanic treatment for evaluation.

  • 0 views
  • 10 Aug, 2022
  • 1 location
Safety and Tolerability of the Use of Copaiba in Patients With Oral Cancer Submitted to Radiotherapy

This study aims to propose an alternative and auxiliary methodology for the prevention and treatment of Oral Mucositis (OM) in patients undergoing radiotherapy or radio and chemotherapy for head and neck neoplasms through the use of copaiba-based mouthwash, since the treatment that currently has proven efficacy for the prevention of …

oral cancer
carcinoma
neck tumor
intensity-modulated radiation therapy
mucositis
  • 0 views
  • 23 Apr, 2022
  • 1 location