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Found 13 clinical trials
Study to Evaluate Safety and Efficacy of DB-020 to Protect Hearing in Patients Receiving Cisplatin for Cancer Treatment

The purpose of this study is to evaluate whether DB-020 administered via an injection in the middle ear prevents hearing loss in participants who will receive high doses of cisplatin as part of their treatment for cancer.

  • 0 views
  • 22 Aug, 2021
  • 14 locations
Intratympanic N-Acetylcysteine for Prevention of Cisplatin-induced Ototoxicity.

Although many intratympanic agents have been attempted, N-Acetylcysteine (NAC) appears to be the most promising and is a powerful, commonly used anti-oxidant. The goal of this prospective phase 2 randomized controlled trial is to determine the optimal dosage and effectiveness of intratympanic NAC injection in reducing hearing loss in head …

  • 3 views
  • 29 Sep, 2021
  • 1 location
Low-Dose Weekly vs High-Dose Cisplatin

This study is a prospective open-label randomized clinical trial. Following informed consent eligible LASCCHN patients (n=100) planned for CRT will be stratified by tumor p16 status and then randomized in a 1:1 fashion to either concurrent HD cisplatin or concurrent weekly LD cisplatin.

  • 0 views
  • 09 Sep, 2021
  • 3 locations
Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma

The primary objective of this protocol is to evaluate the response rate of bilateral disease participants who have at least one eye with advanced intra-ocular retinoblastoma (stratum B) using upfront therapy with chemotherapy delivered directly to the eye. The main biology objective is to improve our understanding of the biology …

nervous
neutrophil count
renal function
carboplatin
etoposide
  • 43 views
  • 22 Jan, 2022
  • 1 location
Active Surveillance Bleomycin Carboplatin Etoposide or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors

This phase III trial studies how well active surveillance, bleomycin, carboplatin, etoposide, or cisplatin work in treating pediatric and adult patients with germ cell tumors. Active surveillance may help doctors to monitor subjects with low risk germ cell tumors after their tumor is removed. Drugs used in chemotherapy, such as …

neutrophil count
carboplatin
testicular
carcinoma
human chorionic gonadotropin
  • 454 views
  • 27 Oct, 2021
  • 374 locations
Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery

This partially randomized phase II/III trial studies how well, in combination with surgery, cisplatin and combination chemotherapy works in treating children and young adults with hepatoblastoma or hepatocellular carcinoma. Drugs used in chemotherapy, such as cisplatin, doxorubicin, fluorouracil, vincristine sulfate, carboplatin, etoposide, irinotecan, sorafenib, gemcitabine and oxaliplatin, work in different …

carboplatin
liver cancer
fluorouracil
carcinoma
oxaliplatin
  • 188 views
  • 30 Sep, 2021
  • 139 locations
Intratympanic Administration of N-acetylcysteine for Protection of Cisplatin-induced Ototoxicity

% against Cisplatin-induced ototoxicity. In this case, we will evaluate its effect through the transtympanic administration in both ears.

  • 0 views
  • 19 Feb, 2021
  • 1 location
Treatment of Radiation and Cisplatin Induced Toxicities With Tempol

week trial, mucositis, nephrotoxicity, and ototoxicity will be monitored and assessed.

absolute neutrophil count
neutrophil count
head and neck cancer
squamous cell carcinoma of the head and neck
tempol
  • 8 views
  • 04 Jul, 2021
  • 5 locations
Multichannel Vestibular Implant Early Feasibility Study

evaluate this approach in up to ten human subjects with bilateral vestibular deficiency due to gentamicin ototoxicity or other causes of inner ear dysfunction.

bilateral vestibulopathy
nystagmus
imbalance
gentamicin
  • 2 views
  • 16 Sep, 2021
  • 1 location
Verification of the Efficacy/Safety of the Dual Drug Delivery for Hearing Loss

This study is a prospective, randomized pilot study. To verify an efficacy and safety of the dual drug injectable delivery vehicle, patients who have not responded to the existing standard treatment will be enrolled. Hearing test and endoscopy of tympanic membrane will be conducted after intratympanic treatment for evaluation.

  • 0 views
  • 22 Aug, 2021
  • 1 location