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Found 278 clinical trials
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Study of LY3410738 Administered to Patients With Advanced Solid Tumors With IDH1 Mutations

This is an open-label, multicenter Phase 1 study to evaluate safety, tolerability and preliminary efficacy of oral LY3410738 in patients with IDH1 R132-mutant advanced solid tumor types, including but not limited to cholangiocarcinoma, chondrosarcoma, and glioma.

metastasis
immunomodulators
cancer chemotherapy
measurable disease
gemcitabine
  • 1 views
  • 17 Oct, 2021
  • 51 locations
None
HANSE - Holistic Implementation Study Assessing a Northern German Interdisciplinary Lung Cancer Screening Effort

The HANSE study is primarily intended as a pilot to provide evidence that a holistic and effective lung cancer screening program can be implemented in Germany and that such a screening program can be integrated in the current infrastructure of certified lung cancer centers.

lung cancer
lung cancer screening
emphysema
cancer
lung carcinoma
  • 0 views
  • 17 Jun, 2021
  • 3 locations
None
Multicenter Pheochromocytoma and Paraganglioma Evaluation

Target population: Patients with (1) newly diagnosed or (2) past history of pheochromocytomas and paragangliomas (PPGL) or (3) carrier of genetic mutations in known PPGL susceptibility genes. International multicenter prospective cohort study with randomized intervention (special care follow-up vs. standard care follow-up). All patients will receive instructions about follow-up at …

adrenal pheochromocytoma
special care
paraganglioma
pheochromocytoma
  • 36 views
  • 24 Jan, 2021
  • 1 location
None
Improving Tobacco Treatment Rates for Outpatient Cancer Patients Who Smoke

The main purpose of this research study is to evaluate the effectiveness of "nudges" to clinicians, to patients, or to both in increasing Tobacco Use Treatment Service (TUTS) referral and engagement; and to explore clinician, patient, inner setting (e.g., clinic), and outer setting (e.g., payment structures) mechanisms related to TUTS …

cancer
primary cancer
tobacco smoke
smoke tobacco
  • 0 views
  • 31 Jul, 2021
  • 1 location
None
IMPACt of an Enhanced Screening Program on the Detection of Non-AIDS NEOplasms in HIV Patients

Introduction: The incidence of malignancies is higher in the HIV-infected population than in the general population, and it is already one of the leading causes of death in people living with the virus. It is estimated that the situation will be aggravated by the progressive aging of the HIV-infected population. …

  • 0 views
  • 15 Feb, 2021
  • 1 location
None
Positron Emission Tomography (PET)/Computed Tomography (CT) and Roentgen in Lung Cancer: Evaluation of Patients in General Practice

The prognosis of lung cancer depends much on the stage of the disease at the time of diagnosis. Only 16 % of lung cancer can be offered curative intended surgery. Chest x-ray is the gate-keeper in lung cancer diagnosis, but it has a miss rate of 20-60 %. A false …

x-rays
ct scan
  • 3 views
  • 07 Nov, 2020
  • 2 locations
None
DianaWeb: Before and After Study Online Based Participatory Research on Breast Cancer Women

DianaWeb is a community-based participatory research (CBPR) offered to Italian breast cancer patients. The aim of the study is the evaluation of effectiveness of a lifestyle and nutrition intervention to improve the prognosis. DianaWeb study utilizes an interactive website - http://www.dianaweb.org/ - to monitor patient life-style, and to obtain clinical, …

  • 0 views
  • 07 Oct, 2021
  • 1 location
None
Iobenguane I-131 or Crizotinib and Standard Therapy in Treating Younger Patients With Newly-Diagnosed High-Risk Neuroblastoma or Ganglioneuroblastoma

This phase III trial studies iobenguane I-131 or crizotinib and standard therapy in treating younger patients with newly-diagnosed high-risk neuroblastoma or ganglioneuroblastoma. Radioactive drugs, such as iobenguane I-131, may carry radiation directly to tumor cells and not harm normal cells. Crizotinib may stop the growth of tumor cells by blocking …

shortening fraction
doxorubicin
carboplatin
mycn protein
conventional surgery
  • 66 views
  • 03 Sep, 2021
  • 105 locations
None
M6620 Plus Standard Treatment in Oesophageal and Other Cancer

This Phase I study will test the combination of a novel ATR inhibitor (M6620) with chemoradiotherapy in oesophageal cancer; utilizing three experimental cohorts (Stage A1, A2 and B).

esophageal cancer
ATR
carcinoma
gilbert's syndrome
chemoradiotherapy
  • 20 views
  • 23 Jan, 2021
  • 4 locations
None
A Geriatric Oncology Collaborative Care Intervention for Older Adults With Advanced Cancer

The purpose of this research study is to develop a geriatric oncology collaborative care intervention to enhance the quality of life, symptom burden, and functional outcomes of older adults with advanced gastrointestinal (GI) and genitourinary (GU) cancers.

  • 0 views
  • 30 Sep, 2021
  • 1 location