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Found 277 clinical trials
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A Study of CHeckpoint Inhibitors in Men With prOgressive Metastatic Castrate Resistant Prostate Cancer Characterized by a Mismatch Repair Deficiency or Biallelic CDK12 Inactivation

The primary objective is to assess the activity and efficacy of pembrolizumab, a checkpoint inhibitor, in Veterans with metastatic castration-resistant prostate cancer (mCRPC) characterized by either mismatch repair deficiency (dMMR) or biallelic inactivation of CDK12 (CDK12-/-). The secondary objectives involve determining the frequency with which dMMR and CDK12-/- occur in …

  • 7 views
  • 16 Jul, 2021
  • 8 locations
None
Proof-of-concept Study of Ibrutinib in c-MYC and HER2 Amplified Oesophagogastric Carcinoma

Some cancers of the oesophagus and stomach express excessive copies of either the cMYC (Myelocytomatosis oncogene) gene, the HER2 (Human epidermal growth factor receptor 2) gene or both. These genes may potentially contribute to the growth and spread of cancer.Ibrutinib is a drug that is already used in the treatment …

  • 50 views
  • 23 Jan, 2021
  • 1 location
None
TheraSphere & Treatment of Unresectable Primary or Unresectable Secondary Liver Cancer

Protocol Synopsis Title A Humanitarian Device Exemption Use Protocol of TheraSphere For Treatment of Unresectable Primary or Secondary Liver Neoplasia Supplier BTG International Canada Inc. Type of Clinical Use Post-Marketing: TheraSphere commercially distributed under HDE # 980006 Objectives Provide supervised access to TheraSphere therapy at this institution Evaluate response to …

  • 0 views
  • 23 Jan, 2021
  • 1 location
None
A Study of LOXO-292 in Participants With Advanced Solid Tumors RET Fusion-Positive Solid Tumors and Medullary Thyroid Cancer

) administered orally to participants with advanced solid tumors, including rearranged during transfection (RET)-fusion-positive solid tumors, medullary thyroid cancer (MTC) and other tumors with RET activation

ret inhibitor
cancer
kidney function test
RET
systemic therapy
  • 1244 views
  • 21 Oct, 2021
  • 162 locations
None
Symptom Management Implementation of Patient Reported Outcomes in Oncology

Deficits in the management of common symptoms cause substantial morbidity for cancer patients.Because the health care delivery system is structured to be reactive and not proactive, there are missed opportunities to optimize symptom control. Growth in Internet access and proliferation of smartphones has created an opportunity to re-engineer cancer care …

symptom control
cancer care
gastrointestinal surgery
gynecologic surgery
gastrointestinal cancer
  • 5 views
  • 25 Jan, 2021
  • 5 locations
None
Prevention of Obesity-related Cancers: Setting up of a Multi-Cancer Education and Prevention Program in Hong Kong

and prostate cancer as compared to other cancers. It is well recognized that screening could effectively reduce mortality for these three obesity-related cancers when they are detected at an earlier

mammogram
overweight or obesity
hypertension
cancer
weight control
  • 3 views
  • 26 Jan, 2021
  • 1 location
None
A Study to Examine the Value of Broad Agnostic Next Generation Sequencing (NGS) Panel Testing Versus Reimbursed Organ-directed NGS: a Belgian Precision Study of the BSMO in Collaboration With the Cancer Center

which they could benefit and hampers progress. The same genes can be mutated in other cancer types, other than the reimbursed context, but are not detected due to the organ-specific approach in

breast cancer
cancer
EGFR
  • 0 views
  • 05 Jun, 2021
  • 12 locations
None
Nivolumab and Ipilimumab +/- UV1 Vaccination as Second Line Treatment in Patients With Malignant Mesothelioma

The objective of the study is to induce a meaningful progression-free survival benefit in patients with Malign Pleural Mesothelioma (MPM) after progression on first line standard platinum doublet chemotherapy, by treating with nivolumab and ipilimumab with or without UV1 vaccine.

neutrophil count
platelet count
measurable disease
pemetrexed
MRI
  • 30 views
  • 24 Jan, 2021
  • 6 locations
None
Hypofractionated Vs Conventional Fractionated Postmastectomy Radiotherapy for High Risk Breast Cancer

The study was designed to investigate whether hypofractionated adjuvant radiotherapy is noninferior to conventionally fractionated adjuvant radiotherapy in terms of efficacy and toxicities for high risk breast cancer patients treated with mastectomy

  • 0 views
  • 22 Jan, 2021
  • 2 locations
None
Hypofractionated Vs Conventional Fractionated Radiotherapy After Breast Conserving Surgery

The study was designed to investigate whether hypofractionated radiotherapy(HF-RT) is noninferior to conventionally fractionated radiotherapy (CF-RT) in terms of tumor loco-regional control for patients after breast conserving surgery

erbb2
axillary lymph node dissection
invasive breast cancer
ki-67
HER2
  • 2 views
  • 23 Jan, 2021
  • 4 locations