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Found 54 clinical trials
The Effects of Whole-body Exercise to Improve Swallowing Function in Older Adults With Dementia

Swallowing impairment (dysphagia) is extremely common in older adults living with dementia due to age-related changes in swallowing and other disease-specific impairments. Dysphagia is commonly

aerobic exercise
dementia
malnutrition
  • 0 views
  • 04 May, 2022
  • 1 location
Neuroimmune Dysfunction in Alcohol Use Disorder

The objective of this proposal is to advance medication development for alcohol use disorder by examining the efficacy and mechanisms of action of minocycline, a neuroimmune modulator, as a potential treatment. This study has important clinical implications, as the available treatments for alcohol use disorder are only modestly effective and …

heavy drinking
minocycline
alcohol use disorder
Accepts healthy volunteers
  • 45 views
  • 10 Oct, 2021
  • 1 location
Venetoclax With Combination Chemotherapy in Treating Patients With Newly Diagnosed or Relapsed or Refractory Acute Myeloid Leukemia

This phase Ib/II trial studies the best dose and side effects of venetoclax and how well it works when given with combination chemotherapy in treating patients with newly diagnosed acute myeloid leukemia or acute myeloid leukemia that has come back or does not respond to treatment. Venetoclax may stop the …

refractory acute myeloid leukemia (aml)
fludarabine
blast cells
idarubicin
cancer
  • 312 views
  • 29 Jan, 2022
  • 1 location
Immunosuppressant Combined With Pirfenidone in CTD-ILD

A prospective cohort study was used to observe the efficacy and safety of different immunosuppressive agents with/wo pirfenidone on CTD-ILD patients in Qilu Hospital of Shandong University for 36 months.The main research endpoints are lung function, patient dyspnea score, 6-minute walking distance, imaging indicators, primary disease activity, adverse reactions, etc.

progressive systemic sclerosis
pirfenidone
dyspnea
rheumatism
immunosuppressive
  • 0 views
  • 24 Jun, 2021
  • 1 location
Neoadjuvant Chemoradiation for Resectable Glioblastoma (NeoGlio)

Preoperative therapy has not been well studied in resectable glioblastoma. This study attempts to prospectively assess the feasibility and efficacy of preoperative chemo radiation in improving local control, as this is the predominant mode of failure in these patients leading to poor outcomes. This Phase II study design would be …

neutrophil count
chemoradiotherapy
blood transfusion
karnofsky performance status
gross total resection
  • 2 views
  • 22 Mar, 2022
  • 2 locations
Venetoclax and Decitabine in Treating Participants With Relapsed/Refractory Acute Myeloid Leukemia or Relapsed High-Risk Myelodysplastic Syndrome

This phase II trial studies how well venetoclax and decitabine work in treating participants with acute myeloid leukemia that has come back or does not respond to treatment, or with high-risk myelodysplastic syndrome that has come back. Drugs used in chemotherapy, such as venetoclax and decitabine, work in different ways …

decitabine
chronic myelomonocytic leukemia
blast cells
cancer
myeloid leukemia
  • 54 views
  • 02 May, 2022
  • 1 location
Niraparib + Dostarlimab In BRCA Mutated Breast Cancer

This research study involves pre-operative therapy that is specifically targeted for breast cancer in individuals with BRCA and PALB2 mutations. The names of the study drugs involved in this study are: Niraparib (Zejula) Dostarlimab

palb2
core needle biopsy
invasive breast cancer
BRCA2
HER2
  • 0 views
  • 12 Jul, 2022
  • 4 locations
BEACON: HDR Brachytherapy, EBRT and STAD for the Treatment of Local and Pelvic Recurrence of Prostate Cancer After Radiation Therapy (BEACON)

The purpose of this study is to evaluate the safety and effectiveness of combining high-dose-rate (HDR) brachytherapy with external beam radiotherapy (EBRT) to the pelvis and 6 months of hormonal therapy, otherwise known as short term androgen deprivation therapy (STAD), as treatment for prostate cancer that has come back in …

  • 9 views
  • 04 Mar, 2022
  • 1 location
Randomized Clinical Trial of a Multi-Modal Palliative Care Intervention

Adults diagnosed with metastatic cancer commonly experience depression and anxiety symptoms, which can interfere with advance care planning. This randomized clinical trial evaluates a novel, piloted, primary palliative care intervention that addresses advance care planning and psychosocial needs of patients with metastatic cancer. The intervention focuses on patients with elevated …

solid tumor
cancer
  • 0 views
  • 23 Mar, 2022
  • 1 location
Validation of Blood Biomarkers for Alzheimer's Disease (ALZAN)

Alzheimer's disease (AD) has gradually become one of the major global public health issues due to its prevalence, which increases with age and life expectancy, and the economic cost of caring for patients whose cognitive decline progressively leads to loss of functional autonomy. The diagnosis of AD is based on …

beta amyloid protein
cognitive assessment
alzheimer's disease
amyloid
cognitive decline
  • 0 views
  • 25 Jul, 2022
  • 3 locations