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Found 71 clinical trials
Featured trial
Safety and Efficacy of Retifanlimab (INCMGA00012) Alone or in Combination With Other Therapies in Participants With Advanced or Metastatic Endometrial Cancer Who Have Progressed on or After Platinum-based Chemotherapy. (POD1UM-204)

This is a multicenter, open-label, nonrandomized, Phase 2 umbrella study of retifanlimab in participants who have advanced or metastatic endometrial cancer that has progressed on or after platinum-based chemotherapy. retifanlimab will be administered as monotherapy or in combination with other immunotherapy or targeted agents.

platinum-based chemotherapy
metastatic endometrial cancer
  • 17 Jun, 2022
  • 49 locations
Featured trial
A Phase 1b Study of INCMGA00012 in Combination With Other Therapies in Patients With Advanced Solid Tumors Carcinoma

The purpose of this study is to determine the safety, preliminary evidence of clinical activity, and recommended Phase 2 dose (RP2D) of INCMGA00012 in combination with other agents that may improve the therapeutic efficacy of anti-PD-1 monotherapy.

solid tumors
  • 10 May, 2022
  • 9 locations
Administration of a Molecular Complex of Resins, Polysaccharides and Polyphenols in Irritable Bowel Syndrome.

This study is aimed to investigate the efficacy and safety of Colilen IBS, a Medical Device made of natural substances, even when taken in addition to other therapies, for the treatment of

abdominal pain
  • 18 Dec, 2021
  • 3 locations
Remote Ischemic Conditioning for Motor Recovery After Acute Ischemic Stroke

The most recent treatment for stroke rehabilitation is to combine physical training with other therapies to enhance or accelerate recovery.The hypothesis of this study is that remote ischemic

  • 17 Mar, 2022
Use of 3 4-Diaminopyridine in Lambert Eaton Myasthenic Syndrome

associated with Lambert -Eaton Myasthenic Syndrome, and hopefully decrease the need for prednisone, and other therapies previously required to control your symptoms. The duration of the use of

  • 07 Nov, 2020
  • 1 location
Multi Cohort Study of Tazemetostat in Combination With Various Treatments For R/R Hematologic Malignancies

This phase 1b/2 trial studies how safely the EZH2 inhibitor tazemetostat works with other therapies in various hematological malignancies. Tazemetostat has been found to be a safe and effective

  • 10 Mar, 2022
  • 1 location
Urine Alkalinisation to Prevent AKI in COVID-19

The aim is to explore the feasibility and safety of urine alkalinisation in critically ill patients with COVID-19.

  • 19 Aug, 2021
  • 1 location
Processed Amniotic Fluid (pAF) for the Treatment of Chronic Wounds

A prospective randomized controlled study to determine the safety and feasibility of using processed amniotic fluid (pAF) to expedite healing in chronic wounds.

hyperbaric oxygen
wound treatment
  • 24 Mar, 2022
Tamoxifen Therapy for Myotubular Myopathy

This is a phase 1 / 2, randomized, double-blinded, single cross-over study, with a washout period between treatment regimens, to test the efficacy and safety of tamoxifen therapy to improve motor and respiratory function in males with XLMTM.

  • 04 Jul, 2021
  • 4 locations
A Study of Enfortumab Vedotin Alone or With Other Therapies for Treatment of Urothelial Cancer (EV-103)

This study will test an experimental drug (enfortumab vedotin) alone and with different combinations of anticancer therapies. Pembrolizumab is an immune checkpoint inhibitor (CPI) that is used to treat patients with cancer of the urinary system (urothelial cancer). This type of cancer includes cancer of the bladder, renal pelvis, ureter …

metastatic urothelial carcinoma
metastatic cancer
platinum-based chemotherapy
  • 21 Apr, 2022
  • 105 locations