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Found 41 clinical trials
Prevention of Symptomatic Skeletal Events With Denosumab Administered Every 4 Weeks Versus Every 12 Weeks

The aim of the trial is to test the hypothesis that the benefit of denosumab is maintained if administered only every 12 weeks as compared to every 4 weeks.

calcium
metastasis
ct scan
pet/ct scan
cancer
  • 72 views
  • 21 Apr, 2022
  • 62 locations
Testing New Strategies for Patients Hospitalised With HIV-associated Disseminated Tuberculosis (NEW-STRAT TB)

The New Strat-TB trial is a superiority Phase III randomised control clinical trial with a 2X2 factorial design. The main aim of the study is to assess the efficacy and safety of high dose rifampicin and levofloxacin for 14 days in addition to standard TB therapy with or without steroids …

  • 0 views
  • 23 Apr, 2022
A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia

ALLTogether collects the experience of previously successful treatment of infants, children and young adults, with ALL from a number of well-renowned study groups into a new master protocol, which is both a comprehensive system for stratification and treatment of ALL in this age-group as well as the basis for several …

imatinib
doxorubicin
vincristine
inotuzumab
dexamethasone
  • 71 views
  • 15 Jun, 2022
  • 59 locations
Hypertension Intervention to Reduce Osteonecrosis in Children With Acute Lymphoblastic Leukemia/Lymphoma

conventional antihypertensive control (targeted to the 90-95th percentile for age, sex, and height) on the incidence of radiographically extensive osteonecrosis in children and young adults receiving treatment

lymphoblastic leukemia
antihypertensive drugs
leukemia
ambulatory blood pressure monitoring
antihypertensive therapy
  • 0 views
  • 24 Mar, 2022
  • 3 locations
Initial Management of MRONJ Stages I and II a Clinical Trial With Detection of Salivary Biomarkers

Medication-related osteonecrosis of the jaw (MRONJ) is a serious complication in patients receiving antiresorptive therapies, such as Bisphosphonates and Denosumab. It is defined by the presence

  • 0 views
  • 24 Feb, 2021
  • 1 location
Impact of a POPOP on Preoperative Health, Eligibility, and Clinical & Patient-Reported Outcomes in TJA

In this pilot study, we will test the hypothesis that a POPOP for currently ineligible UAMS orthopedic surgery patients wanting hip or knee replacement improves markers of preoperative health, ability to reach a BMI threshold <40 kg/m2 required for surgical eligibility, and postoperative outcomes versus SOC.

total knee replacement
osteoarthritis
avascular necrosis
  • 0 views
  • 24 Mar, 2022
Physica System Total Knee Replacement Registry Study

The primary objective of this study is to obtain long-term implant survivorship (out to 10 years) and to assess clinical, patient-reported outcome measures, and radiographic data for the commercially available Physica system.

osteoarthritis
arthropathy
arthritis
total knee replacement
knee arthritis
  • 678 views
  • 11 May, 2022
  • 3 locations
LLL Phototherapy in Oral Lesions Resulting From Anti-neoplastic Prevention

referring to oral mucositis (OM), radiodermatitis, osteonecrosis of the jaws (ONJ), hyposalivation and xerostomia, dysgeusia, pain, oral candidiasis (opportunistic infection), trismus, quality of life, oral

antineoplastic
mucositis
  • 0 views
  • 22 Mar, 2022
  • 1 location
Persona Ti-Nidium Post-Market Clinical Follow-up

The main objectives of this study are to evaluate overall clinical performance and safety of the Persona Ti-Nidium implant in total knee arthroplasty.

total knee replacement
joint reconstruction
  • 0 views
  • 29 Sep, 2021
  • 3 locations
Insignia™ Hip Stem Outcomes Study

The objective of this study is to evaluate the safety and effectiveness of the Insignia™ Hip Stem for global market access and post-market clinical follow-up up to 10 years postoperative.

  • 0 views
  • 23 Apr, 2022