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Found 29 clinical trials
Acute Non-severe Osteomyelitis in Children - Outpatient Management Strategy With Oral Antibiotic Therapy Compared to a Standard Strategy With Conventional Hospitalization and Intravenous Antibiotic Therapy: a Randomized Open-label Non-inferiority Study With Bayesian and Medical-economic Analyses.

The incidence of bone and joint infections (BJI) in children (osteomyelitis, septic arthritis and spondylodiscitis) is 22 per 100,000 children in France. Every year, 3,000 children are

antibiotic therapy
antibiotics
fever
  • 0 views
  • 14 Oct, 2021
  • 1 location
Synthetic Cranioplasty PEEK Versus UHMWP: A Randomized Controlled Trial

The purpose of this study is to report our experience with synthetic reconstruction of cranial defects using computer guided milled UHMWP, in terms of benefits and limitations both clinically and radiographically in comparison to PEEK implants.

  • 0 views
  • 13 Mar, 2022
CSP #2001 - Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics (VA Intrepid) (VA INTREPID)

The purpose of this research study is to determine if rifampin, an antibiotic (a medicine that treats infections), is effective in treating osteomyelitis (infection of the bone) of the foot in

diabetes mellitus
rifampin
riboflavin
hemoglobin a1c
glycosylated hemoglobin
  • 660 views
  • 11 Oct, 2022
  • 26 locations
Vitamin D Supplementation in the Armed Forces (D_SAF)

The study will comprise of an original investigation that will take the form of a prospective intervention (two matched groups) study. Condition-1 will be a vitamin D supplementation group (50.000 IU every two months), and Condition-2 will be a placebo supplementation group. The primary research aim of this project is …

vitamin d supplementation
serum pth
Accepts healthy volunteers
stress fracture
vitamin
  • 59 views
  • 08 Feb, 2022
  • 1 location
Bacteriophage Therapy in Patients With Diabetic Foot Osteomyelitis

This is a phase IIa randomized trial designed to evaluate bacteriophage therapy in patients with diabetic foot osteomyelitis.

debridement
diabetic foot
diabetes
  • 0 views
  • 07 Oct, 2022
  • 5 locations
BonE and Joint Infections - Simplifying Treatment in Children Trial (BEST)

This is a multi- centre trial of children with bone and joint infections (BJIs) at eight major paediatric hospitals in Australia and New Zealand. The primary objective is to establish if in children with acute, uncomplicated BJIs, entirely oral antibiotic treatment is not inferior to initial intravenous (IV) treatment for …

antibiotics
  • 0 views
  • 18 Jun, 2022
  • 1 location
Short or Long Antibiotic Regimes in Orthopaedics (SOLARIO)

Research question: If adults with bone or joint infection have local antibiotic therapy, can they do without prolonged treatment with antibiotics by mouth (oral) or injection? Adults with bone or joint infections are usually given long courses of oral antibiotics or into a vein (intravenous) following surgery. It is also …

antibiotic therapy
antibiotics
localised pain
  • 61 views
  • 23 Mar, 2022
  • 18 locations
A Multicenter Phase 3 Confirmatory Trial of Biotherapy Using Cryopreserved Human Umbilical Cord (TTAX01) for Late Stage, Complex Non-healing Diabetic Foot Ulcers (AMBULATE DFU II)

Phase 3 study examines a population of diabetic foot ulcer patients having adequate perfusion, with or without neuropathy, and a high suspicion of associated osteomyelitis in a complex, high grade wound

  • 6 views
  • 24 Oct, 2022
  • 14 locations
A Multicenter Phase 3 Trial of Biotherapy Using Cryopreserved Human Umbilical Cord (TTAX01) for Late Stage, Complex Non-healing Diabetic Foot Ulcers (AMBULATE DFU)

Phase 3 study examines a population of diabetic foot ulcer patients having adequate perfusion, with or without neuropathy, and a high suspicion of associated osteomyelitis in a complex, high grade wound

  • 79 views
  • 29 Oct, 2022
  • 14 locations
Ceftriaxone as Home IV for Staph Infections

Patients who are admitted to hospital with serious infections, such as those in bone, joints or spine, require a long course of intravenous (IV) antibiotics. After an initial treatment course in hospital or through a dedicated outpatient antibiotic program many patients can complete their treatment course at home. Such infections …

cefazolin
foot infection
staphylococcus
abscess
staphylococcus aureus
  • 42 views
  • 16 Feb, 2022
  • 2 locations