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Found 36 clinical trials
Acute Non-severe Osteomyelitis in Children - Outpatient Management Strategy With Oral Antibiotic Therapy Compared to a Standard Strategy With Conventional Hospitalization and Intravenous Antibiotic Therapy: a Randomized Open-label Non-inferiority Study With Bayesian and Medical-economic Analyses.

The incidence of bone and joint infections (BJI) in children (osteomyelitis, septic arthritis and spondylodiscitis) is 22 per 100,000 children in France. Every year, 3,000 children are

antibiotics
antibiotic therapy
fever
  • 0 views
  • 14 Oct, 2021
  • 1 location
Synthetic Cranioplasty PEEK Versus UHMWP: A Randomized Controlled Trial

The purpose of this study is to report our experience with synthetic reconstruction of cranial defects using computer guided milled UHMWP, in terms of benefits and limitations both clinically and radiographically in comparison to PEEK implants.

  • 0 views
  • 13 Mar, 2022
CSP #2001 - Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics (VA Intrepid) (VA INTREPID)

The purpose of this research study is to determine if rifampin, an antibiotic (a medicine that treats infections), is effective in treating osteomyelitis (infection of the bone) of the foot in

hypoglycemic agents
antibiotics
riboflavin
antibiotic therapy
rifampin
  • 660 views
  • 15 Sep, 2022
  • 26 locations
Vitamin D Supplementation in the Armed Forces (D_SAF)

The study will comprise of an original investigation that will take the form of a prospective intervention (two matched groups) study. Condition-1 will be a vitamin D supplementation group (50.000 IU every two months), and Condition-2 will be a placebo supplementation group. The primary research aim of this project is …

soft tissue infection
vitamin d supplementation
serum pth
Accepts healthy volunteers
stress fracture
  • 59 views
  • 08 Feb, 2022
  • 1 location
A Phase IIa Randomized, Parallel Group, Double-blind, Repeat Dose, Investigating the Safety, Tolerability, and Efficacy of Phage Treatment and Standard of Care Antimicrobials for Patients With Diabetic Foot Osteomyelitis

This is a phase IIa randomized trial designed to evaluate bacteriophage therapy in patients with diabetic foot osteomyelitis.

diabetic foot
debridement
diabetes
  • 0 views
  • 15 Sep, 2022
  • 5 locations
BonE and Joint Infections - Simplifying Treatment in Children Trial (BEST)

This is a multi- centre trial of children with bone and joint infections (BJIs) at eight major paediatric hospitals in Australia and New Zealand. The primary objective is to establish if in children with acute, uncomplicated BJIs, entirely oral antibiotic treatment is not inferior to initial intravenous (IV) treatment for …

antibiotics
  • 0 views
  • 18 Jun, 2022
  • 1 location
Short or Long Antibiotic Regimes in Orthopaedics (SOLARIO)

Research question: If adults with bone or joint infection have local antibiotic therapy, can they do without prolonged treatment with antibiotics by mouth (oral) or injection? Adults with bone or joint infections are usually given long courses of oral antibiotics or into a vein (intravenous) following surgery. It is also …

antibiotics
localised pain
antibiotic therapy
  • 61 views
  • 23 Mar, 2022
  • 18 locations
Dalbavancin For The Treatment of Gram Positive Osteoarticular Infections

. Systemic bacterial infections due to Staphylococci such as osteomyelitis and septic arthritis, are conditions which require prolonged IV therapy, typically for at least 3-6 weeks, though sometimes more

dalbavancin
bacterial infections
antibiotics
ortho evra
vancomycin
  • 228 views
  • 26 Feb, 2022
  • 1 location
Ceftriaxone as Home IV for Staph Infections

Patients who are admitted to hospital with serious infections, such as those in bone, joints or spine, require a long course of intravenous (IV) antibiotics. After an initial treatment course in hospital or through a dedicated outpatient antibiotic program many patients can complete their treatment course at home. Such infections …

septic arthritis
cloxacillin
staphylococcus aureus
prosthetic joint infection
diabetic foot
  • 42 views
  • 16 Feb, 2022
  • 2 locations
Oral-only Antibiotics for Bone and Joint Infections in Children (CHILD@HOME_BJI)

A nationwide, multicenter, randomized, non-inferiority trial of children with bone and joint infections. The primary objective is to determine if oral-only antibiotics (experimental arm) is non-inferior to initial intravenous antibiotics followed by oral therapy (control arm). Children will be randomized 1:1. The total treatment duration is identical in both groups. …

antibiotics
  • 15 views
  • 29 Jul, 2022
  • 1 location