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Found 44 clinical trials
Dural Puncture Epidural VS Standard Epidural on Physician Top-ups During Labour Analgesia

The purpose of this prospective randomized controlled study is to compare the number of physician top-up interventions during the first stage of labour between two different neuraxial analgesia techniques : the dural puncture epidural and the standard epidural.

  • 22 Feb, 2021
  • 1 location
Above-Knee-High Application of Lower Limb Compression and Its Impact on Clinical Outcome in Patients Hospitalized With Heart Failure Exacerbation. (A-KHALIFE)

Heart failure (HF) remains one of the most common causes of hospitalization with high morbidity and mortality, and its worldwide prevalence is increasing. Despite notable progress in outcomes for HF the rate of early rehospitalization for HF (re-HHF) remains high, especially in the first 30 days. The rate of 30-day …

decompensated heart failure
congestive heart failure
  • 04 Oct, 2022
  • 1 location
Clinical Trial of Nabilone for Aggression in Adults With Intellectual and Developmental Disabilities (N-AND)

Innovative treatments are urgently needed for severe behavioural problems (SBPs) in adults with intellectual and developmental disabilities (IDD). Although a synthetic cannabinoid, nabilone may be a plausible and safe alternative to treat SBP, safety and efficacy of nabilone in people with IDD has never been evaluated. The investigators propose to …

  • 19 Apr, 2022
  • 1 location
Evaluation of the Efficacy of a Two-week EMST on Dysphagia in Parkinsonian Patients (EMST-PS)

This is an interventional therapy study designed to evaluate the efficacy of a two-week intervention, i.e. training with a specialized exhalation training device (called expiratory muscle strength training; EMST150 or EMST75; Aspire Products, Gainsville, FL) on swallowing function in patients with neurodegenerative Parkinsonian disorders. This study involves a routine endoscopic …

gaze palsy
parkinson's disease
  • 19 Apr, 2022
  • 2 locations
REmote Cardiac MOnitoring of At-risk SYNCope Patients After Emergency Department Discharge - A Multicenter Randomized Controlled Trial: REMOSYNCED (REMOSYNCED)

Syncope (fainting) is a common reason for emergency department (ED) presentation. Fainting can be caused by heart conditions such as irregular heart rhythm (arrhythmia) that can be life-threatening, structural heart problems, or serious conditions not related to the heart. The standard or usual treatment for the majority of patients at-risk …

  • 24 Oct, 2022
  • 1 location
Lokelma for RAAS Maximisation in CKD & Heart Failure. (LIFT)

Background: CKD in patients with heart failure (HF) is common and associated with poor prognosis. Despite evidence of benefit with Renin-Angiotensin-Aldosterone-System inhibitor (RAASi) agents, they are avoided due to fear of hyperkalaemia. New potassium binders, e.g. Sodium Zirconium Cyclosilicate (SZC), reduce incidence of hyperkalaemia in CKD-HF patients and hence may …

heart failure
  • 14 Mar, 2022
Orthostatic Hypotension in Hypertensive Patient Hospitalized in Internal Medicine (IP-OP)

The two scientific societies FADOI and SIIA have decided to start a collaborative study protocol that, through the application of a simple and homogeneous method to diagnose orthostatic

  • 15 Mar, 2022
  • 13 locations
Sporadic Degenerative Ataxia With Adult Onset: Natural History Study

The key goals of SPORTAX-NHS is to compare the phenotype of multiple system atrophy of cerebellar type (MSA-C) and sporadic adult onset ataxia of unknown aetiology (SAOA) and to determine the rate of disease progression in both groups including determination of the factors that predict the development of MSA-C vs. …

  • 21 Jan, 2021
  • 17 locations
Natural History Study of Synucleinopathies

). In rare cases, hypotension on standing (a disorder known as orthostatic hypotension) may be the only clinical finding. This "pre-motor" autonomic stage suggests that the disease process may not yet

multiple system atrophy
  • 25 Jan, 2022
  • 8 locations
The Management of Transient Loss of Consciousness (TLOC) and Suspected Syncope in European Emergency Departments: a Prospective Cohort Study (SEED)

Prospective multi centre cohort study examining the clinical presentation, diagnostic tests, and management of adult Emergency Department (ED) patients presenting with Transient Loss of Consciousness (TLOC) either undifferentiated or thought to be of syncopal origin.

  • 22 Oct, 2022
  • 52 locations